Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:1.3.5.1 (succinate dehydrogenase)
 8,177 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the chondrocytes of the humerus epiphysis of newborn and 8-, 30- and 60-day-old albino rats, glycogen phosphorylase and succinate dehydrogenase activity was found. The enzymatic pattern of glycogen phosphorylase and succinate dehydrogenase diverges significantly within the age groups. In the chondrocytes of cartilage epiphysis of newborn and 8-day-old animals glycogen phosphorylase is distinctly present. The enzyme is reduced in 30- and 60-day-old rats. The initial moderate reactions of succinate dehydrogenase in the column cartilage and in the proximal hypertrophic cells demonstrate an additional activity from 30-day-old animals. The osteoblasts of the metaphysis demonstrated a strong reaction.
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PMID:[Studies on the distribution of glycogen phosphorylase and succinate dehydrogenase in the humeral epiphysis of various-age rats]. 116 98

The effects of zinc on the enzymes of femoral tissue were investigated in weanling rats that had been given zinc sulfate (1.0 mg Zn2+/100 g body wt) p.o. for 3 days. Administration of zinc caused a marked elevation of alkaline phosphatase and acid phosphatase activities, whereas it did not cause significant changes in succinate dehydrogenase, 5'-nucleotidase, ATPase, pyrophosphatase and beta-N-acetylglucosaminidase activities. The effect of zinc was greater on alkaline phosphatase of the femoral diaphysis. Zinc content of the femoral diaphysis was raised significantly by administration of zinc. The addition of zinc in concentrations of 10(-2)-10(2) microM did not produce a significant increase in alkaline phosphatase activity in the femoral diaphysis, indicating that zinc could not activate the enzyme. Administration of cycloheximide or actinomycin D completely inhibited the increase in alkaline phosphatase activity produced by administration of zinc. DNA content of the femoral diaphysis, but not epiphysis, was increased markedly by administration of zinc. The increases in both alkaline phosphatase activity and DNA content of the femoral diaphysis were not caused by administration of copper, manganese, cobalt, nickel and chromium(III). The present investigation suggests that zinc may induce the increase in alkaline phosphatase related to DNA synthesis and, as a result, stimulate bone growth.
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PMID:Action of zinc on bone metabolism in rats. Increases in alkaline phosphatase activity and DNA content. 395 86

The paper is concerned with the effect of epiphysisectomy on the glucose-6-phosphate dehydrogenase, glutathion reductase, succinate dehydrogenase activities and the content of sodium and potassium in the cortex and medullary layers of the kidneys under spontaneous diuresis and water load. It is shown that in rats without epiphysis the activity of glucose-6-phosphate dehydrogenase is lowered both in the cortex and medullary layers of the kidneys. The activity of glutathion reductase rises in the cortex layer of the kidneys only under water load. A disturbance is found in the sodium and potassium distribution between the cortex and medullary layers of the kidneys. An assumption is advanced on a possible role of epiphysis in regulating the kidney functions.
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PMID:[Glucose-6-phosphate dehydrogenase, glutathione reductase, succinate dehydrogenase activities and content of sodium and potassium in kidneys of epiphysisectomized rats under spontaneous diuresis and water load]. 725 56

The dose-effect of stannous chloride on biochemical indices was examined in weanling male rats given oral doses of 0.3, 1.0 and 2.0 mg/kg at 12-h intervals for 90 days. The 3.0 mg/kg dose caused significant decreases of the relative weights of the femur, calcium concentration, lactic dehydrogenase and alkaline phosphatase activities in the serum, succinate dehydrogenase activity in the liver, and calcium content and acid phosphatase activity in the femoral diaphysis and epiphysis. Of the above indices, the 1.0 mg/kg dose produced significant reduction of succinate dehydrogenase activity in the liver, and calcium content and acid phosphatase activity in the femoral epiphysis. Those significant decreases were not observed with the 0.3 mg/kg dose, although a slight but not significant decrease of calcium content in the femoral epiphysis was observed. These results suggest that the no-effect level of inorganic tin orally administered would be lower than 0.6 mg/kg/day.
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PMID:Dose-effect of inorganic tin on biochemical indices in rats. 742 35