Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.3.5.1 (succinate dehydrogenase)
 8,177 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Intrauterine thymectomy was successfully performed on 9 guinea pig foetuses at the gestational age of 36-48 days. This resulted in a significant suppression of the phytohemagglutinin (PHA) response of the whole blood lymphocytes at the age of 3 mth. The in utero-thymectomized guinea pigs and their littermate non-thymectomized controls were operated on by making 4 symmetrical dorsal skin incisions and by subcutaneously implanting 8 standardized pieces of viscose cellulose sponge. On the 1st, 3rd, 5th and 10th days the tensile strength of the wounds was determined and the implants were analysed histologically and enzymehistochemically. At the time of incipient fibroplasia on the 5th post-operative day, the tensile strength of the wounds, the number of fibroblasts and the activities of aminopeptidase and succinate dehydrogenase were clearly less in the guinea pigs which had been thymectomized in utero. These findings indicate that adequate thymic function was necessary for normal fibroblast proliferation, since intrauterine thymectomy led to a temporary delay in the beginning of the fibroblastic phase in wound healing.
Thymus 1983 Sep
PMID:Effect of intrauterine thymectomy on granulation tissue formation. An experimental study. 660 77

A study was carried out to examine the effects of forced running exercise in the growing stage in male ICR mice and of Astragalus membranaceus (As) on their immune functions. The mice were divided at 4 weeks of age into 4 groups. The first group of mice received forced running exercise (E-group), the second group was given As (As-group), the third group received the forced running exercise and was given As (E+As-group) and the fourth group was a control receiving no treatment. The exercise received was forced running at 15 m/min on a flat floor without any slope for 60min a day. The mice of groups E and E+As were exercised 5 times a week for 12 weeks. The mice of groups As and E+As were given As p. o. at 200 mg/kg per day (5 days/week) for 12 weeks. The results obtained were as follows: 1. After 12 weeks of forced running exercise, the weight of the anterior tibialis muscle and succinate dehydrogenase activity in the anterior tibialis muscle increased significantly in groups E and E+As compared with the control group. Thymus weight showed a tendency to increase in groups E and E+As as compared with the control group. 2. The potentiation of the phagocytic function of the reticuloendothelial system examined by the carbon clearance method was seen in groups E, As and E+As. 3. Superoxide anion production of peritoneal macrophages significantly increased in groups As and E+As, but not in group E. 4. The acid phosphatase activity of peritoneal macrophages in groups E, As and E+As significantly increased compared with the control group. 5. Interleukin 1 production by macrophages remained in all groups. 6. The proliferation of splenocytes induced by Con A in groups E, As and E+As significantly increased compared with the control group. These results suggested that forced running exercise in the growing stage in mice and the administration of As enhanced immune functions and that they might also intensify the functioning of the host defense system.
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PMID:[Effects of exercise in the growing stage in mice and of Astragalus membranaceus on immune functions]. 838 67