Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.3.5.1 (succinate dehydrogenase)
 8,177 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Development of the hepatocyte heterogeneity was studied histochemically during the postnatal period. At birth ornithine carbamoyltransferase (OCT). succinate dehydrogenase (SDH) and NADH dehydrogenase (NADHDH) activities were evenly distributed throughout the liver acinus. Slightly uneven distribution within the acinus appeared at 3 days after birth in SDH and at 4 days after birth in OCT and NADHDH, changing to that of adult type at 10 or 12 days after birth which is characterized by a marked difference in the activities between zone 1 and 3. However, in animals of all age groups studied, glycogen was decreased mainly in zone 1 and 2 after 6 or 10 h of fasting and glucose 6-phosphatase activity was markedly reduced or disappeared in zone 3 and often in zone 2 after carbon tetrachloride administration. The results show that so-called "functional and structural heterogeneity among hepatocytes" consists of at least two different components, that formed gradually during the postnatal development and that existing already at birth.
 ...
PMID:The heterogeneity of hepatocytes during the postnatal development of the mouse. 624 91

Mechanisms of subcellular dysfunction of the liver in sepsis are still obscure. The present study investigates changes in oxidative phosphorylative activity and calcium-induced respiration of rat liver mitochondria following live Escherichia coli injection (E coli, Serotype: 0--18. A 1.25--1.5 X 10(9)/100 gm body wt inoculum of E coli bacteria was injected via the tail vein, causing a 100% mortality rate within 24 hours after injection. In order to determine alteration of liver mitochondrial membrane permeability, serum ornithine carbamoyltransferase activity was measured following E coli injection. This activity increased ten to 100-fold over that of controls with time following injection. However, the yield of liver mitochondria from treated rats, estimated by the amount of collected mitochondrial protein and the recovery rate of succinate dehydrogenase activity in the final mitochondrial suspensions, was not significantly different from that of controls. Mitochondrial oxidative phosphorylative activity measured using glutamate as a substrate was enhanced throughout all period to death (P less than 0.01 at three and six hours, P less than 0.05 in the fatal stage) and was associated with concomitant increases in respiratory control ratios. Similar results were obtained using beta-hydroxybutyrate as a substrate. This enhancement was accompanied by an increase in 2-4-dinitrophenol-stimulated ATPase activity (160% at three hours and 130% in the fatal stage). Calcium-induced stimulation of mitochondrial respiration as well as initial calcium uptake rate linked to respiration, using glutamate as a substrate, were higher in liver mitochondria from rats with E coli treatment than in those of controls throughout all periods (P less than 0.01 or less). These results suggest the coexistence of hyperfunctioning as well as deteriorated mitochondria following lethal treatment with E coli.
 ...
PMID:A study of oxidative phosphorylative activity and calcium-induced respiration of rat liver mitochondria following living Escherichia coli injection. 675 40