Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.3.5.1 (succinate dehydrogenase)
 8,177 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two muscles involved in locomotion the vastus lateralis and the gastrocnemius, were compared on a variety of histochemical an biochemical properties. Ten active males, age 20 - 24 years, served as subjects. Fibre type distributions, type I, type IIA and type IIB, as determined from samples extracted by muscle biopsy were similar in both muscles. In addition, no significant difference (p greater than 0.05) was found between fibre types in each muscle for fibre size, relative area, capillaries per fibre and the ratio of capillaries per fibre area. The activities of a number of enzymes representative of energy supplying pathways - the citric acid cycle (succinate dehydrogenase, SHD; beta-hydroxyacyl CoA dehydrogenase, HADH), glycogenolysis (total phosphorylase, PHOSP), glycolysis (phosphofructokinase, PFK) - were of similar magnitude between the two muscles. The only exception noted was for the activity of a glycolytic enzyme, lactate dehydrogenase, LDH, where a 16% higher value was observed in the vastus lateralis. The close degree of homogeneity displayed between these two muscles may be of significance in providing for a functional synchrony to occur in locomotor activities of varying intensity.
 ...
PMID:Human vastus lateralis and gastrocnemius muscles. A comparative histochemical and biochemical analysis. 617 18

This study investigated the hypothesis that the adaptations in skeletal muscle to prolonged exercise overload, involving high levels of adenosine triphosphate (ATP) resynthesis, result in a preferential adaptation to pathways involved in energy metabolism. The change in selected properties of skeletal muscle during a period of reduced activity was used as an indication of training-induced adaptations. Muscle biopsy samples from the vastus lateralis were analyzed 6 weeks and 18 weeks after a 5-month, intense, intermittent training program. Significant reductions occurred (p less than 0.05) in enzyme activities representative of the citric acid cycle (succinic dehydrogenase, SDH), beta oxidation of free fatty acids (3-hydroxyacyl CoA dehydrogenase, HADH), glycogenolysis (total phosphorylase, PHOSP), and glycolysis (phosphofructokinase, PFK). In addition, reductions in concentration (p less than 0.05) were also found for ATP, creatine phosphate (CP), and glycogen. With the exception of PFK, all enzyme changes and the high energy phosphates reached new stable levels by at least the 6th week of detraining. The absence of changes in muscle cell type and size during the detraining period supports the hypothesis that adaptations in energy potential of the muscle cell predominate in this type of high intensity overload situation.
 ...
PMID:Biochemical and histochemical alterations in skeletal muscle in man during a period of reduced activity. 721 1

A study was made of respiration, heat production, K+ output and ultrastructure of wheat root cells treated for 6 h with rotenone (10 microM), an inhibitor of HADH-ubiquinone oxidoreductase (Complex I). Besides, the involvement of alternative pathways for adaptation to this inhibitor was studied. After 20 min of treatment, a brightened mitochondrial matrix and mitochondria with torus shapes were observed. We propose that the outer area of mitochondria increases due to their torus shapes, and this can point to the activating of extremal NAD(P)H-dehydrogenase, which uses enternal NAD(P)H. Further on the normal ultrastructure of mitochondria was observed, which may result from activation of succinate dehydrogenase and rotenone resistant NAD(P)H-dehydrogenase. After 1 h of treatment, a decrease in respiration, heat production, K+ output and pH increase of incubation medium were observed. Starting from 2 h of incubation and up to the end of the experiment, an increase of respiration and heat production was observed, pointing to the activation of oxidative phosphorilation. Besides, re-entry of K+ and pH decrease in the incubation medium were observed. We conclude that these findings may indicate to a possible adaptation of root cells to this inhibitor. We propose that the torus shape of mitochondria may be associated with function of external NAD(P)H-dehydrogenase.
 ...
PMID:[Ultrastructural characteristics of mitochondria during cell adaptation to rotenone]. 1570 79