Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.3.5.1 (succinate dehydrogenase)
 8,177 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The functional thyroid status of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-treated rats is unknown. Therefore, activities of certain thyroid-responsive enzymes were examined in the livers of adult male Sprague-Dawley rats 1 week after treatment with TCDD (6.25, 25 or 100 micrograms/kg). Activity of the thyroid-responsive flavin L-glycerol-3-phosphate dehydrogenase (per mg mitochondrial protein) was decreased slightly in livers of TCDD-treated rats, while that of succinate dehydrogenase remained unchanged. In contrast, activities (per mg supernatant protein) of three thyroid-responsive NADP-dependent cytosolic enzymes, malic enzyme, glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase, were increased by TCDD treatment in a dose-dependent manner. Lactate dehydrogenase (activity per mg supernatant protein) was also augmented slightly 1 week after TCDD administration. Liver mass was increased by TCDD treatment in a dose-dependent manner, but DNA content per liver was similar at all doses examined. Total hepatic protein, expressed per liver or mg hepatic DNA, was increased in TCDD-treated rats when compared to their pair-fed counterparts. The decreased activity of the mitochondrial L-glycerol-3-phosphate dehydrogenase, in contrast to the increased activities of the supernatant enzymes, malic enzyme, glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase, is not consistent with a shift in functional thyroid status following TCDD treatment.
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PMID:Hepatic indices of thyroid status in rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin. 381 71

Four groups of 1-month-old rats were fed with standard diet (SD) for a month, 46% SD + 54% sorbitol, 54% saccharose or 27% sorbitol + 27% saccharose. Fed with 54% sorbitol and with 27% sorbitol + 27% saccharose differed from rats given 54% saccharose and 100% SD (they were thin, had hyperreaction to light, diarrhea). Liver mass in all the tests in autumn and winter (AuWi) is lower than in spring and summer (SpSu). It is lower in 54% sorbitol, higher in 27% sorbitol + 27% saccharose, the highest in 54% saccharose and 100% SD. Specific activity (SA) of lactate dehydrogenase (LDG) is higher, glucose-6-phosphate dehydrogenase (G-6-PDG) is lower in SpSu than in AuWi in 4 diets. In 54% sorbitol and 27% sorbitol + 27% saccharose SA of LDG, G-6-PDG and succinate dehydrogenase (SDG) is not higher than in 100 SD. SA of SDG and LDG in SpSu is higher than in AuWi, G-6-PDG is lower in SpSu. SA of these three enzymes is not higher in 54% sorbitol than in 100% SD in contrast to 4-fold rise of SA of sorbitol dehydrogenase. Biorhythms of enzyme SA reflect the results of interaction of adaptive molecular mechanisms of the body, including genetic ones, with changing environment.
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PMID:[Effects of high quantities of sorbitol and saccharose in the diet on enzymes activity and liver mass of rats in different seasons of the year]. 1789 2