Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.3.5.1 (succinate dehydrogenase)
 8,177 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Immunization of rabbits with increasing doses of Cl. botulinum toxoid, type B, led to the development in the kidneys of a focal intracapillary productive glomerulonephritis, and also of productive endo- and perivasculites. Blood letting (in the amount of 1% of body weight) aggravated the morphological picture of the affection on account of supervention of the alternative and exudative components. At the same time blood letting led to reduction of the NAD-diaphorase, succinic dehydrogenase and glucose-6-phosphatase activity in the epithelium of the proximal portions of the nephrons.
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PMID:[Histological and histochemical changes in the kidneys of rabbits immunized with Cl. botulinum toxoid type B in combination with blood loss]. 100 41

29 patients aged 6-16 with glomerulonephritis lasting 4-5 years received multimodality treatment with plasmapheresis as a component. The majority of the patients suffered from primary glomerulonephritis in mesangio- or membrano-proliferative morphological variants. Previous long-term conventional therapy (prednisolone, cytostatics, anticoagulants and antiaggregation drugs) failed. The test course comprised 1-3 plasmapheresis sessions (centrifuge method on [symbol: see text] apparatus), cyclophosphamide or maintenance methyl-prednisolone pulse therapy, heparin and curantil. One-third of the patients achieved remission lasting from 5 months to 3 years, in the other one-third the improvement was as short as 2-4 weeks, and the last one-third appeared non-responders. Improvement of clinical indices occurred in parallel with trends to reduction in the levels of CIC, IgG, B-lymphocytes, T-helpers, inhibition of lymphocyte succinate dehydrogenase activity, better phagocytosis. No complications which may prohibit plasmapheresis use in glomerulonephritis were observed. Adjuvant plasmapheresis use in glomerulonephritis treatment needs further studies.
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PMID:[Plasmapheresis in the combined therapy of progressive forms of glomerulonephritis]. 794 Mar 67

Hormone sensitivity in patients suffering from glomerulonephritis of nephrotic type was assessed cytochemically by corticosteroid action on activity of mitochondrial enzymes (alpha-glycerophosphate dehydrogenase, succinate dehydrogenase) and by sensitivity of peripheral blood mononuclear cells to antiproliferative effect of dexamethasone in vitro. In glucocorticosteroid-sensitive patients the activity of alpha-glycerophosphate dehydrogenase, succinate dehydrogenase rises in interaction with prednisolone in vitro. In the resistant patients enzymatic activity in lymphocytes came down, peripheral blood mononuclear cells before and in the course of treatment retained resistance to glucocorticoids irrespective of the treatment results. Alpha-glycerophosphate dehydrogenase to succinate dehydrogenase index varied from 0 to 0.33 and 0.4 to 5.1 in the resistant and sensitive patients, respectively.
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PMID:[The hormonal sensitivity of glomerulonephritis patients]. 877 74