Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.3.5.1 (succinate dehydrogenase)
 8,177 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effects of a three-month course of oral ketotifen on the histology and histochemistry of nasal mucosa, assessed on punch biopsy material, were studied in 30 adults with perennial allergic rhinitis. Ketotifen treatment was associated with reversal of the histopathology and enzyme changes in every case. Two months after stopping therapy, the rhinitis changes had returned in all 10 patients from whom posttreatment punch biopsies were taken. Other patients whose symptoms were relieved declined a third biopsy. Five normal volunteers were included as controls. The pretreatment mucosal biopsies showed variations in goblet cell population, thickened basement membranes, hypertrophied serous glands, diminished or absent mucus glands, and varying degrees of cellular infiltrates. There was marked edema with separation of collagen fibers and epithelial metaplasia especially in patients with long-standing allergy and nasal polyps. Ketotifen therapy was linked with reversal of the epithelial changes to normal, marked reduction in edema and cellular infiltration, and the retention of granules by mast cells. Changes in mucosal content of succinic dehydrogenase and acid phosphatase; high tissue levels of both which are associated with allergic rhinitis, also diminished towards the control levels during ketotifen therapy, only to return after its cessation.
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PMID:The histological and histochemical effects of ketotifen in allergic rhinitis. 201 59

Ten patients with perennial allergic rhinitis were subjected to CO2 laser turbinectomy. Tiny (1 mm3) biopsy specimens were taken at the time of surgery and 1 month thereafter. The biopsy specimens were processed for transmission electron microscopy. Also, the activity of succinic dehydrogenase and cholinesterase enzymes was measured. The study showed that laser turbinectomy was followed by reduction in the number and activity of the glandular acini in the laser-treated areas. This reduction is ascribed to the local destructive effect of laser energy on the glandular acini and on the surrounding cholinergic nerve fibers. The enzymatic activity of the cholinergic nerve fibers themselves, however, did not diminish, indicating that laser surgery has no inhibitory effect on the local allergic reaction.
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PMID:Laser surgery for allergic rhinitis: the effect on seromucinous glands. 1022 3