Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.3.5.1 (
succinate dehydrogenase
)
8,177
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Following in vitro translation of the
22 kDa peroxisomal membrane protein
(Pmp22p), gel filtration analysis of the post-ribosomal supernatant revealed that Pmp22p forms two complexes. Complex I is of high molecular weight, results in a crosslinking product of 80 kDa, and by co-immunoprecipitation with anti-TCP1 antibody was identified as TRiC. In
complex II
Pmp22p was crosslinked to a yet unknown polypeptide of 40 kDa (P40). This complex exhibited much higher efficiency to insert Pmp22p into the peroxisomal membrane compared to complex I. In a model we suggest that newly synthesized Pmp22p is first bound to TRiC before being transferred to P40 which may function as a cytosolic Pmp22p receptor.
...
PMID:Cytosolic factors mediate protein insertion into the peroxisomal membrane. 930 39
