Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.3.1.51 (
HDR
)
605
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
When
CCD
-based free-space fluorescence molecular tomography (FMT) is used for imaging of fluorescent targets with a large concentration difference, the limited dynamic range of the
CCD
diminishes the localization and quantitative accuracy of FMT. To overcome this, we present a high-dynamic-range FMT (HDR-FMT) method. Under the multiple-exposure scheme,
HDR
fluorescence projection images are constructed using the recovered
CCD
response curve. Image reconstruction is implemented using iterative reweighted L1 regularization which can reduce artifacts by using fewer
HDR
fluorescence projection images. Phantom and in vivo animal studies indicate that localization of fluorescent targets with a large concentration difference is effectively improved with
HDR
-FMT and with good quantitative accuracy.
...
PMID:High-dynamic-range fluorescence molecular tomography for imaging of fluorescent targets with large concentration differences. 2755 67
