Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:1.3.1.51 (HDR)
 605 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Modern high technology has recently brought a precision treatment modality in the field of brachytherapy for cancer patients. Ir-192 manual afterloading (hair pin technique of Ir-192 wire) replaced the technique utilizing Ra-226 needles at our department in 1973. In May 1991, microSelectron-HDR (Ir-192 micro-source of 370 GBq) was installed in Osaka University Hospital. Preliminary analysis of phase I/II study resulted in no significant differences between the incidence of an acute mucosal reaction as well as early tumor response after high and low dose rate interstitial brachytherapy for oral cancer. Since April 1992, a phase III study has been under way to completely eliminate the problem of hospital personnel exposure to radiation in the field of brachytherapy. The introduction of remote after-loading of Ir-192 micro-source has resulted in improvements in elderly patient care during the interstitial brachytherapy for malignancies. The indications for HDR brachytherapy have been expanded, and new technology was developed to improve the local cure of the disease, such as linked double button technique for oral cancer, template interstitial brachytherapy for perineal cancer, and postoperative brachytherapy using intraoperative flexible catheter placement for locally unresectable disease or microscopically residual disease. Through these meticulous efforts, HDR interstitial brachytherapy will soon become a satisfactory substitute for traditional LDR interstitial brachytherapy.
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PMID:[192Ir brachytherapy]. 823 75

Low dose rate brachytherapy is well established treatment modality of oral cancer. Data about high dose rate brachytherapy (HDR BT) are still scarce with heterogenous results. The aim of our study was to evaluate preliminary results in a small group of oral cancer patients treated by HDR BT. Seventeen applications were performed on 16 patients in years 2001-2004, in 15 cases for new tumor (mobile tongue 10x, floor of mouth 2x, lip 3x) and in 2 cases for local recurrence after radiotherapy. Ten treatments (for T1-2N0 tumors and recurrences) were performed with brachytherapy alone (18 x 3 Gy twice daily), seven patients (T2-3 N0-2 tumors) were treated with a combination of external beam radiotherapy (40-68 Gy) and brachytherapy (2-6 x 3 Gy twice daily). The plastic tubes technique was used for brachytherapy. Follow-up periods were between 8-46 months (median 17). Fifteen patients were disease free during follow-up period. One patient (brachytherapy alone for T2N0M0 mobile tongue cancer) died immediately after neck dissection for the neck recurrence due to the heart failure. The other one died due to distant metastases but without local recurrence. Acute complications were mucositis gr. II at maximum, late complications were ulcer of soft tissues in 3 and superficial bone necrosis in 2 cases. The evaluation of the brachytherapy implants was done according ICRU 58 recommendations. Hyperfractionated high dose rate brachytherapy alone or as a boost to external beam radiotherapy is feasible with promising local control. Carefull planning of the implant and mandibular shielding are necessary to avoid complications.
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PMID:High dose rate brachytherapy in the treatment of oral cancer--the preliminary one institution experience. 1665 93