Gene/Protein Disease Symptom Drug Enzyme Compound
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Chemical analysis of dimethyl sulfoxide reductase from Rhodobacter sphaeroides f. sp. denitrificans has shown that its molybdenum center contains two molybdopterin guanine dinucleotide molecules and a single atom of molybdenum. The enzyme, which exists as a monomer of 86 kDa, was shown to contain 1 mol of molybdenum, 4 mol of organic phosphate, and 2 mol of guanine per mole of protein. In addition, the relative yield of Form A, a fluorescent derivative of molybdopterin, was twice that obtained from sulfite oxidase, a protein which contains a single molybdopterin per molybdenum. These findings correlate with the recent report of the presence of two molybdopterin ligands in the tungsten cofactor of aldehyde ferredoxin oxidoreductase from Pyrococcus furiosus, providing the first example of a bis(pterin)molybdenum cofactor and extending this structural motif to the molybdopterin dinucleotide enzymes.
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PMID:Identification of the molybdenum cofactor of dimethyl sulfoxide reductase from Rhodobacter sphaeroides f. sp. denitrificans as bis(molybdopterin guanine dinucleotide)molybdenum. 855 38

Violence against intimate partners threatens public health and social cohesion, and its prevalence could increase with an attitude of justification of such violence. The objective of this article was to use religion and ethnicity as proxies for culture to examine Ghanaian women's acceptance of being beaten. We employed descriptive and binary logistic regression statistics applied to Multiple Indicator Cluster Survey data collected in 2011 in Ghana. With a weighted sample of 10,627 women, the findings revealed that more than half (59.83%, 95% confidence interval (CI) = 57.41%, 62.2%) of the respondents justified at least one form of intimate partner violence (IPV) or another and being a Mole-Dagbani (adjusted odds ratio [AOR] = 1.41; 95%; CI = 1.05, 1.90) and/or in a polygamous marriage/union (AOR = 1.22; 95% CI = 1.04, 1.420) were significant risk factors for justifying IPV. Activism in promoting IPV-free communities has to be group-specific to reach those in need of interventions.
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PMID:Do ethnicity and polygyny contribute to justification of men beating women in Ghana? 2632 74