Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.17.3.2 (xanthine oxidase)
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Human Gene/Protein
EVI-5 11.9
xanthine oxidase 11.8
xanthine oxidoreductase 11.7
CYPIIIA4 10.9
xanthine dehydrogenase 10.7
2P domain potassium channel 10.3
aldehyde oxidase 1 10.0
aldehyde oxidase 9.9
SAPK-interacting protein 1 9.9
CT39 9.9
nuclear prelamin A recognition factor 9.9
IOP2 9.9
urate transporter 1 9.8
XDH 9.7
Aldehyde oxidase 1 9.6
GLUT9 9.3
TALK-1 9.0
nucleoside phosphorylase 8.9
Butyrophilin 8.8
butyrophilin 8.8
gamma-Butyrobetaine hydroxylase 8.7
H2B.2 8.7
guanine deaminase 8.6
sulfite oxidase 8.6
alanine-glyoxylate aminotransferase 2 8.6
arylformamidase 8.4
C6orf4 8.4
POLD2 8.4
GTF2H1 8.4
IMPD 8.4
Neuronal protein 8.4
organic anion transporter 1 8.4
Guanase 8.3
DCTN2 8.3
phosphoribosyl pyrophosphate amidotransferase 8.3
IOP1 8.3
TRIM38 8.3
SEPW1 8.2
MT1R 8.2
GB5 8.2
carboxypeptidase B1 8.1
GTK 8.1
guanine aminohydrolase 8.1
NAD(+) kinase 8.1
Ferroxidase 8.0
Superoxide dismutase 7.9
TALK-2 7.9
MOCS2 7.7
transmembrane transport protein 7.7
PLA2G3 7.6
GPHN 7.6
NOS1 protein 7.6
HMOX2 7.6
MOCS1 7.6
RST 7.5
DUSP16 7.5
molybdenum cofactor sulfurase 7.5
N-acetyltransferase 2 7.4
BTN2A1 7.4
LZP 7.4
PAPA 7.2
gep 7.2
organic anion transporter 4 7.2
TXN 7.2
Catalase 7.2
purine nucleoside phosphorylase 7.2
Sulfite oxidase 7.1
histone deacetylase 11 7.1
hCNT2 7.1
TMX 7.1
MOCS3 7.1
peroxiredoxin 4 7.1
NPT1 7.1
TIPARP 7.1
superoxide dismutase 7.0
JNK-interacting protein 3 7.0
adipophilin 7.0
sulfonylurea receptor 2 7.0
extracellular superoxide dismutase 7.0
heart protein 6.9
more...
Disease
Chronic clonorchiasis 11.9
Molybdenum deficiency 10.3
Xanthine oxidase deficiency 10.1
Xanthinuria 9.9
Yoshida Sarcoma 9.1
Sulfite oxidase deficiency 8.6
APRT deficiency 8.6
hyperuricemia 8.5
streptoccocal 8.3
gout 8.0
Colonic obstruction 7.9
histiocytic leukemia 7.7
GPHN 7.6
Recurrent herpes labialis 7.6
Mammary adenocarcinoma 7.6
podagra 7.6
tophi 7.6
Gouty arthritis 7.5
Acute gouty arthritis 7.4
PAPA 7.0
uricosuria 7.0
Disuse atrophy 6.8
Molybdenum cofactor deficiency 6.6
renin-dependent hypertension 6.5
CG3 6.4
ADA deficiency 6.4
Exertional rhabdomyolysis 6.3
tumor lysis syndrome 6.2
FBD 6.1
ALS2 5.9
Rotavirus gastroenteritis 5.9
Lesch-Nyhan syndrome 5.8
diabetic cataract 5.7
Harley 5.7
PNP deficiency 5.6
hepatic echinococcosis 5.6
alcoholic cardiomyopathy 5.5
renal ischemia 5.5
VDI 5.5
Oxygen toxicity 5.4
PMS 5.3
Acute myocardial ischemia 5.2
Lowe 5.2
Chronic mountain sickness 5.2
acute arthritis 5.2
Acute pyelonephritis 5.2
gastric lesion 5.2
Intestinal ischemia 5.2
Myocardial necrosis 5.1
DRESS syndrome 5.1
Postinfarction 5.1
RHS 5.0
hemoglobinemia 5.0
GSH 4.9
ischemia 4.9
furuncle 4.8
Pfeiffer 4.7
Transient ischemia 4.7
Acute mesenteric ischemia 4.6
Carotid body 4.6
Carotid body 4.6
Carotid body 4.6
Endothelial dysfunction 4.6
chronic granulomatous disease 4.5
Spinal cord ischemia 4.5
nephrosis 4.5
Diaphragm 4.5
UIP 4.4
Bianchi 4.4
hyperoxaluria 4.4
LPI 4.4
Testicular torsion 4.4
HPC 4.3
complicated pregnancy 4.3
McArdle's disease 4.3
Insulinoma 4.2
rheumatism 4.2
Spontaneous bacterial peritonitis 4.2
NAME 4.2
pellagra 4.2
more...
Symptom
Macula 5.0
autodigestion 4.6
throat irritation 4.4
Anoxia 4.4
catarrh 4.3
hyperoxia 4.3
skin damage 4.1
disturbed balance 4.1
athetosis 3.9
No adverse effect 3.6
prostration 3.4
renal colic 3.2
hyperesthesia 2.8
ketonuria 2.8
oliguria 2.6
leg edema 2.5
rigors 2.2
twitching 1.9
functional recovery 1.9
colic 1.8
eds 1.8
muscle rigidity 1.8
respiratory distress 1.6
hypertonia 1.6
dry eye 1.5
tonic-clonic seizure 1.5
exhaustion 1.3
hypocapnia 1.2
hypothermia 1.1
neuralgia 1.1
arthralgia 1.1
cachexia 1.0
angina 1.0
flushing 0.8
skin irritation 0.8
myalgia 0.8
acute stress 0.7
starvation 0.6
acidity 0.6
erythema 0.5
hypercapnia 0.5
asthenia 0.5
HSA 0.3
fatigue 0.3
polyuria 0.3
dizziness 0.2
exertional dyspnea 0.2
memory loss 0.1
pelvic pain -0.1
anesthesia -0.2
hepatosplenomegaly -0.2
seizures -0.2
anorexia -0.3
nausea -0.3
diarrhea -0.3
shortness of breath -0.5
Ill -0.6
collapse -0.6
paresis -0.6
hypotonia -0.6
agitation -0.7
vomiting -0.7
sleepiness -0.8
spasm -1.0
weakness -1.0
dystonia -1.1
overweight -1.2
pain -1.3
headache -1.3
abdominal pain -1.5
thinning -1.6
chest pain -2.2
discomfort -2.6
cough -2.6
discomfort -2.7
Drug
Amflutizole 11.9
Dezaguanine 11.9
Y-700 11.6
Febuxostat 11.1
Fenazox 10.3
Desciclovir 10.3
Lodoxamide tromethamine 9.7
Chrysanthemum flower 9.6
Pirenoxine 9.6
Guanoxabenz 9.6
Fudosteine 9.3
Troxipide 9.3
Moco 9.0
Bifemelane hydrochloride 8.9
Succinobucol 8.9
Gefarnate 8.7
Bupleurum root 8.7
Angelica dahurica root 8.7
Atractylodes rhizome 8.7
Pinellia tuber 8.6
Scutellaria root 8.5
Tantum 8.1
Nadifloxacin 8.1
Maribavir 8.0
7,8-Dihydroneopterin 7.9
Argininosuccinate 7.8
Rasburicase 7.8
Desferal 7.7
Bendazac 7.6
TMX 7.6
Desferal 7.6
Dipentum 7.6
Pentastarch 7.6
Plaunotol 7.5
Nitecapone 7.4
Sesame oil 7.4
Rasburicase 7.4
Oxyphenbutazone 7.4
Tanespimycin 7.4
Rifalazil 7.3
Oxyphenbutazone 7.2
Rebamipide 7.2
Caraway 7.2
Lisofylline 7.1
Orgotein 7.1
Zinc sulfate 6.9
Acadesine 6.9
Zinc sulfate 6.9
Sulfaphenazole 6.9
Bicine 6.9
Malonaldehyde 6.8
Teduglutide 6.8
Bucillamine 6.6
Mercaptopurine 6.5
NBT 6.5
Ponalrestat 6.5
Tirapazamine 6.4
1-Deoxynojirimycin 6.2
Myricetin 6.2
Lantus 6.2
Tenidap 6.1
Pancreatin 6.1
Sesamol 6.0
Sulla 5.9
Nafamostat mesilate 5.9
FAD 5.8
Jujube 5.7
Nilvadipine 5.7
Vitamin K2 5.7
FeCl3 5.6
Hakka 5.6
Cicletanine 5.5
Dazoxiben 5.5
NADH 5.4
Compound 19 5.4
Cilnidipine 5.4
Zovirax 5.3
Nabumetone 5.3
Adenosine deaminase 5.3
ascorbate 5.2
more...
Enzyme
xanthine oxidase 11.9
xanthine dehydrogenase 11.2
quinaldic acid 4-oxidoreductase 10.9
quinaldic acid 4-oxidoreductase 10.9
aldehyde oxidase 9.9
isoquinoline 1-oxidoreductase 9.9
4-hydroxybenzoyl-CoA reductase 9.6
quinoline 2-oxidoreductase 9.4
melilotate hydroxylase 9.3
pyrimidine deoxyribonucleoside 2'-hydroxylase 9.3
guanase 9.0
sulfite oxidase 8.7
nicotinic acid hydroxylase 8.6
guanosine deaminase 8.6
sulfite oxidase 8.5
histolysain 8.4
uricase 8.3
allantoicase 8.1
thymine 7-hydroxylase 7.9
retinal oxidase 7.8
amidophosphoribosyltransferase 7.6
2-nitropropane dioxygenase 7.5
indole 2,3-dioxygenase 7.5
aldehyde dehydrogenase 7.4
EC 1.3.2.3 7.3
NADPH oxidase 7.2
purine nucleoside phosphorylase 7.2
NADPH oxidase 7.0
allantoinase 6.9
superoxide dismutase 6.9
formylmethanofuran dehydrogenase 6.8
octanol dehydrogenase 6.7
putrescine oxidase 6.7
superoxide reductase 6.6
glucose oxidase 6.5
catalase 6.5
kynurenine formamidase 6.5
DHOdehase 6.5
prostacyclin synthase 6.5
adenosine deaminase 6.5
adenosine deaminase 6.4
D-amino acid aminotransferase 6.4
CO dehydrogenase 6.4
p-cresol methylhydroxylase 6.3
thiopurine methyltransferase 6.2
adenine deaminase 6.2
NADH-cytochrome b5 reductase 6.1
GMP reductase 6.1
GMP synthase 6.1
DAP II 6.1
glutathione peroxidase 6.1
glycolate dehydrogenase 6.1
AMP deaminase 6.0
adenine phosphoribosyltransferase 6.0
benzoate dioxygenase 6.0
deoxyhypusine hydroxylase 5.9
nucleoside hydrolase 5.8
adenylosuccinate synthetase 5.8
cytochrome b6/f complex 5.7
nitrite reductase 5.7
lipoxygenase 5.7
pseudolysin 5.7
GMP synthetase 5.7
lactate oxidase 5.7
nitrite reductase 5.7
nitrite reductase 5.6
cysteine conjugate beta-lyase 5.6
histidase 5.6
choline dehydrogenase 5.6
glutathione reductase 5.6
nitrate reductase 5.6
nitrate reductase 5.6
myo-inositol oxygenase 5.6
nitrate reductase 5.6
NADPH:quinone oxidoreductase 5.6
ferredoxin reductase 5.6
nitrate reductase 5.6
nitrate reductase 5.6
gamma-butyrobetaine hydroxylase 5.6
hypoxanthine-guanine phosphoribosyltransferase 5.5
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Compound
2-Amino-6-chloropurine 11.9
Colchizin 11.9
1H-pyrrolo[3,2-c]pyridine-4,6(5H,7H)-dione 11.9
S-Methylisothiourea sulfate 11.9
6-(chloromethyl)-9H-purine 11.9
1,7-dihydropyrano[4,3-b]pyrrole-4,6-dione 11.9
4-Hydroxypteridine 11.9
Afzelechin 11.9
Oxypurinol 11.0
Jacareubin 10.9
N-phenylisonicotinamide 10.9
2-naphthyl laurate 10.9
2-hydroxy-6-pentadecylbenzoic acid 10.9
1-chlorophthalazine 10.9
3,5-dichloro-2-hydroxybenzenesulfonic acid 10.6
C15H10O7 10.3
C14H8N4O6 10.3
ethyl undecanoate 10.3
C15H10O7 10.3
Urothione 10.3
C15H10O7 10.3
C15H10O7 10.3
4-chloro-7H-pyrrolo[2,3-d]pyrimidine 10.3
C9H13N3O5 10.3
2-phenyl-1H-imidazole 10.2
Xanthine 10.1
sebacamide 9.9
C15H10O7 9.9
Luteolin 7-O-glucoside 9.9
Benziodarone 9.9
Cardol 9.9
Pedalitin 9.9
Tinoridine 9.9
C15H10O7 9.9
C8H8O3 9.9
C20H24O6 9.9
HPP 9.8
Purpurogallin 9.8
stearaldehyde 9.6
C15H10O7 9.6
Norathyriol 9.4
2-quinoxalinecarboxamide 9.3
Rubrofusarin 9.3
Aldophosphamide 9.3
3-hydroxy-4-methoxybenzaldehyde 9.3
2-allyl-4-methoxyphenol 9.3
Lithospermic acid 9.2
Hypoxanthine 9.1
Balofloxacin 9.1
2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one 9.1
Rubrofusarin 9.1
AFMU 8.9
3-Deazaguanine 8.9
Panaxatriol 8.9
Robinetin 8.9
N-hydroxyguanidine 8.8
Benzbromarone 8.7
Scopolin 8.7
2-Nitrofluorene 8.7
3-Methylxanthine 8.7
2,3,4-trihydroxybenzoic acid 8.7
o-Nitroanisole 8.7
Cypridina luciferin 8.7
5-phenylisoxazole 8.6
Hypolaetin 8.6
Panaxadiol 8.6
Isovitexin 8.6
Molybdenum cofactor 8.5
Coformycin 8.5
C30H50 8.4
Gossypin 8.4
1-phenyl-1H-1,2,3-triazole 8.3
Murexide 8.3
Isoorientin 8.3
Dynemicin A 8.3
4000 M 8.2
Tricetin 8.2
13(S)-HPODE 8.2
Murexide 8.2
superoxide radical 8.2
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