Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.17.3.2 (xanthine oxidase)
 8,383 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
xanthine oxidase 7867
superoxide dismutase 1704
catalase 1347
Sep 595
xanthine oxidoreductase 440
glutathione peroxidase 383
xanthine dehydrogenase 364
Mol 349
GSH 307
nitric oxide synthase 306
NADPH 282
SOD 278
ATP 260
NADH 254
myeloperoxidase 242
cytochrome c 225
aldehyde oxidase 199
lactate dehydrogenase 191
Superoxide dismutase 189
cyclooxygenase 163
peroxidase 158
microsomal 157
NAD 143
Catalase 135
tumor necrosis factor 126
lipopolysaccharide 122
adenosine deaminase 119
glutathione reductase 119
lipoxygenase 116
NMR 115
ADP 109
albumin 108
ROS 105
insulin 104
cytochrome P450 98
ATPase 96
inducible nitric oxide synthase 94
EPR 93
cytokine 90
reductase 87
TNF 86
ESR 85
FAD 80
AMP 77
hemoglobin 75
collagen 72
antioxidant enzyme 72
cytochrome P-450 67
caspase-3 66
cytochrome 66
serum albumin 63
alkaline phosphatase 61
purine nucleoside phosphorylase 58
aspartate aminotransferase 57
IL-6 56
oxidoreductase 56
gut 52
angiotensin II 52
endothelial nitric oxide synthase 52
glucose-6-phosphate dehydrogenase 51
MnSOD 49
NAD+ 49
heme oxygenase-1 48
vascular endothelium 47
p38 47
TNF-alpha 47
spermatozoa 46
sulfite oxidase 46
phospholipase A2 45
thymus 45
ferritin 45
ornithine decarboxylase 45
endoplasmic reticulum 43
aldehyde dehydrogenase 43
tyrosinase 43
CO2 43
XDH 41
amylase 41
flavoprotein 40
SDS 37
glutathione S-transferase 37
creatine kinase 37
manganese superoxide dismutase 37
LPS 35
alanine aminotransferase 35
eNOS 35
SIN 34
casein 34
hypoxanthine-guanine phosphoribosyltransferase 34
alcohol dehydrogenase 33
Bcl-2 33
5'-nucleotidase 33
bradykinin 32
interferon-gamma 32
myoglobin 32
glucosidase 31
polypeptide 30
CYP1A2 30
Pseudomonas 30
interleukin-6 29
MAPK 29
renin 29
endothelin-1 29
membrane-bound 28
COX-2 28
guanylate cyclase 28
nucleoside phosphorylase 28
GTP 27
P450 27
IMP 26
NADPH-cytochrome P-450 reductase 26
mast cell 26
CAT 26
transferrin 26
ESI 26
NMDA receptor 25
LDH 25
xenobiotic 25
butyrophilin 25
metallothionein 25
lactoperoxidase 24
DT-diaphorase 24
matrix metalloproteinase 24
p47 24
P-selectin 23
cyclooxygenase-2 23
ERK1 23
neuronal nitric oxide synthase 22
acetylcholinesterase 22
N-acetyltransferase 22
p53 22
C-reactive protein 22
NADP 22
CPR 21
interferon 21
ceruloplasmin 21
urate transporter 1 21
glycoprotein 21
ICAM-1 20
Gen 20
IL-1 20
PKC 20
gamma-glutamyl transpeptidase 20
5-lipoxygenase 20
p65 20
NLRP3 20
tyrosine kinase 20
thrombin 20
lipase 19
Myeloperoxidase 19
lactoferrin 19
IL-10 19
SOD1 19
PEG 19
chymotrypsin 19
phosphodiesterase 19
glucose transporter 19
extracellular signal-regulated kinase 19
Ang II 19
mitogen-activated protein 18
more...
Disease
ischemia 706
gout 361
hyperuricemia 357
GSH 307
cancer 273
hypertension 199
diabetes 198
tumor 187
atherosclerosis 139
heart failure 103
arthritis 89
cardiovascular disease 84
myocardial ischemia 81
depression 78
carcinogenesis 74
renal disease 70
myocardial infarction 67
NAME 64
obesity 59
stroke 51
cerebral ischemia 48
metabolic syndrome 48
sepsis 48
sepsis 46
cold 45
carcinoma 44
hyperglycemia 44
Alzheimer's disease 39
hypercholesterolemia 39
acute pancreatitis 38
SDS 37
type 2 diabetes 37
SEM 35
pulmonary edema 32
pancreatitis 30
renal ischemia 30
renal failure 29
hepatocellular carcinoma 28
vascular disease 26
tophi 24
pulmonary hypertension 23
hyperlipidemia 23
leukemia 23
renal impairment 23
preeclampsia 22
immunodeficiency 22
adult respiratory distress syndrome 22
rheumatoid arthritis 22
hepatitis 21
acute myocardial infarction 21
asthma 21
Parkinson's disease 20
plaque 20
mole 19
proteinuria 19
mole 19
breast cancer 18
tumorigenesis 18
HIV 18
melanoma 18
acute renal failure 18
influenza 17
urolithiasis 17
coronary artery disease 17
congestive heart failure 17
renal insufficiency 16
malaria 16
chronic granulomatous disease 16
tumor lysis syndrome 15
diabetic nephropathy 14
inflammatory bowel disease 14
colitis 14
MCF 14
prostate cancer 14
rheumatism 14
coronary heart disease 13
ventricular fibrillation 13
virus infection 13
sickle cell disease 13
ulcerative colitis 13
glomerulosclerosis 13
fatty liver 12
Lesch-Nyhan syndrome 12
acute promyelocytic leukemia 12
Endothelial dysfunction 12
epilepsy 12
cirrhosis 12
metabolic disorder 12
Evans 12
celiac disease 12
tuberculosis 11
chronic obstructive pulmonary disease 11
West 11
cardiomyopathy 11
Mycobacterium 11
tumor growth 11
dyslipidemia 11
worms 11
lymphoma 10
cornea 10
dementia 10
heart disease 10
colorectal cancer 10
nephrolithiasis 10
cystic fibrosis 10
iron overload 10
neuroblastoma 10
ATM 10
multiple sclerosis 10
coronary occlusion 10
osteoarthritis 9
diabetic retinopathy 9
gastric ulcer 9
anemia 9
Chagas 9
amyotrophic lateral sclerosis 9
liver disease 9
squamous cell carcinoma 9
cataract 9
neutropenia 9
nephrosis 9
adenocarcinoma 9
ADA deficiency 9
essential hypertension 8
bacterial infection 8
fits 8
Pineal 8
infectious diseases 8
solid tumor 8
uterus 8
Blocking 8
dermatitis 8
PMS 8
dehydration 8
premenstrual syndrome 8
glucose intolerance 8
rash 8
APRT deficiency 8
pheochromocytoma 8
necrotizing enterocolitis 8
SAR 8
cholestasis 8
ventricular hypertrophy 8
colon cancer 8
infertility 7
alcoholic fatty liver 7
Crohn's disease 7
malnutrition 7
leukopenia 7
emphysema 7
Infection 7
acute lymphoblastic leukemia 7
liver fibrosis 7
TEM 7
chronic renal failure 7
bladder cancer 7
TEM 7
hepatitis B 7
Epstein 7
glioma 7
more...
Symptom
pain 28
hyperoxia 27
anesthesia 26
seizures 18
fatigue 17
respiratory distress 16
functional recovery 13
diarrhea 12
angina 11
starvation 10
hypothermia 10
exhaustion 9
skin damage 7
acidity 6
headache 6
vomiting 5
collapse 5
weakness 5
nausea 5
erythema 5
arthralgia 4
myalgia 3
anorexia 3
abdominal pain 3
colic 3
cachexia 3
overweight 3
oliguria 3
hypercapnia 3
flushing 3
dizziness 3
Anoxia 3
Ill 2
renal colic 2
twitching 2
agitation 2
autodigestion 2
dry eye 2
acute stress 2
sleepiness 2
dystonia 1
hyperesthesia 1
memory loss 1
skin irritation 1
pelvic pain 1
polyuria 1
hypocapnia 1
tonic-clonic seizure 1
hypertonia 1
discomfort 1
shortness of breath 1
asthenia 1
discomfort 1
hypotonia 1
prostration 1
muscle rigidity 1
hepatosplenomegaly 1
chest pain 1
leg edema 1
exertional dyspnea 1
athetosis 1
neuralgia 1
paresis 1
HSA 1
No adverse effect 1
spasm 1
eds 1
rigors 1
cough 1
catarrh 1
ketonuria 1
disturbed balance 1
thinning 1
throat irritation 1
Macula 1
Drug
NADH 251
ascorbate 226
vitamin E 137
ROS 105
Cardiovasc 88
FAD 80
Febuxostat 80
caffeine 69
Indomethacin 33
NBT 32
Dermatol 32
Ethanol 26
Nitric Oxide 25
lysine 24
Glutathione 22
Vitamin E 19
nitroglycerin 19
FeCl3 18
Adriamycin 15
Desferal 14
Desferal 14
IFN-gamma 14
Mutagen 12
CaCl2 11
Rasburicase 11
CaCl2 11
Albumin 11
CaCl2 11
Ringer's solution 9
Methylene blue 9
Y-700 9
Leaf 9
L-tyrosine 9
IL-2 8
Angiotensin II 8
Nephron 8
CSF 8
Monit 8
Gel 7
Fructose 7
balanced salt solution 7
Adenosine deaminase 7
Acacia 7
Vitamin K 7
Photofrin 6
Sodium nitroprusside 6
Nephron 6
Spectrum 6
Propofol 6
MAP 6
Rebamipide 6
Captopril 6
Myricetin 6
THF 5
BH4 5
Rasburicase 5
Fluorescein 5
Aloe 5
Arsenic trioxide 5
Rutin 5
lactose 5
Omeprazole 5
CTX 4
NH3 4
Cimetidine 4
Ouabain 4
pyridoxal phosphate 4
Heme 4
Moco 4
ETA 4
TMX 4
Glycyrrhiza 4
niacin 4
Cimetidine 4
Portal 3
Ginseng 3
MgSO4 3
ZnO 3
Carotenoid 3
SiO2 3
Riboflavin 3
Histamine 3
Zinc sulfate 3
MRC 3
ICI 3
Fraction 3
Zinc sulfate 3
Iloprost 3
Sesame oil 3
DNase I 3
CAM 3
Dial 3
APD 3
Malonaldehyde 3
Ketotifen 2
EPA 2
Asn 2
Troglitazone 2
Acyclovir 2
NAG 2
Lodoxamide tromethamine 2
Capsicum 2
Atractylodes rhizome 2
TiO2 2
Vitamin K2 2
ddI 2
CoCl2 2
CoCl2 2
RAL 2
Retinoic acid 2
FCV 2
Ginger 2
Triclosan 2
Sesamol 2
Adenosine triphosphate 2
Pirfenidone 2
Scutellaria root 2
Lovastatin 2
ALA 2
Silica gel 2
Sucralfate 2
Silica 2
Gliclazide 2
Indapamide 2
Cellulose acetate 2
MOF 2
Meth 2
Tantum 2
Gastro 2
Tirapazamine 2
all-trans-retinol 2
citric acid 2
Vitamin A 1
CPZ 1
1-Deoxynojirimycin 1
TAC 1
Vitamin B 1
Asthma 1
Amflutizole 1
Desciclovir 1
Bucillamine 1
7,8-Dihydroneopterin 1
Nilvadipine 1
CTC 1
Lisofylline 1
ABC 1
Diphenhydramine 1
Trifluoperazine 1
Piracetam 1
SNL 1
Vena 1
ZnCl2 1
Dipentum 1
Zovirax 1
NaI 1
DMSA 1
Nebivolol 1
Doxycycline 1
EE2 1
Valsartan 1
more...
Enzyme
xanthine oxidase 8383
superoxide dismutase 1877
catalase 1358
xanthine dehydrogenase 750
NADPH oxidase 441
peroxidase 401
glutathione peroxidase 390
NADPH oxidase 359
aldehyde dehydrogenase 234
lactate dehydrogenase 205
aldehyde oxidase 189
NO synthase 137
glucose oxidase 133
glutathione reductase 122
adenosine deaminase 119
adenosine deaminase 119
lipoxygenase 117
ATPase 109
uricase 100
mitogen-activated protein kinase 97
protein kinase C 85
NQO1 68
aspartate aminotransferase 68
alanine aminotransferase 61
alkaline phosphatase 61
phospholipase A2 59
creatine kinase 57
glucose-6-phosphate dehydrogenase 56
purine nucleoside phosphorylase 55
glutathione S-transferase 55
aldehyde dehydrogenase 54
NOS 50
caspase-3 50
diaphorase 50
nitrate reductase 47
sulfite oxidase 47
nitrate reductase 47
nitrate reductase 47
nitrate reductase 47
nitrate reductase 46
sulfite oxidase 46
nitrate reductase 46
tyrosinase 45
ornithine decarboxylase 45
aldehyde dehydrogenase 43
aldehyde dehydrogenase 43
aldehyde dehydrogenase 43
CPR 42
complex I 42
protein kinase 42
monoamine oxidase 40
alcohol dehydrogenase 39
elastase 38
trypsin 38
5'-nucleotidase 35
guanylate cyclase 33
succinate dehydrogenase 32
hypoxanthine-guanine phosphoribosyltransferase 31
guanase 31
gamma-glutamyl transpeptidase 30
ceruloplasmin 30
renin 29
collagenase 28
ERK 26
acetylcholinesterase 26
nitrite reductase 25
nitrite reductase 25
heme oxygenase 25
nitrite reductase 25
ACE 23
phosphodiesterase 22
N-acetyltransferase 22
NADPH-diaphorase 21
diaphorase 21
lipase 20
thrombin 20
NADH dehydrogenase 18
cytochrome oxidase 18
aconitase 16
PARP 16
alpha-glucosidase 16
MEK 15
caspase-1 15
chymotrypsin 15
phospholipase C 15
lysozyme 15
paraoxonase 14
carbonic anhydrase 13
acid phosphatase 13
DCF 13
focal adhesion kinase 13
paraoxonase 13
AST 12
15-lipoxygenase 12
adenine phosphoribosyltransferase 12
urease 12
AMP deaminase 12
urease 12
glutamate dehydrogenase 11
thioredoxin reductase 11
neutrophil elastase 11
luciferase 11
nitrogenase 11
thiopurine methyltransferase 11
beta-glucuronidase 11
glucose-6-phosphatase 11
arginase 11
aldose reductase 10
phospholipase D 10
NADH-cytochrome b5 reductase 10
diamine oxidase 9
adenylate cyclase 9
glutamate dehydrogenase 9
glutamate dehydrogenase 9
IMP dehydrogenase 9
glyceraldehyde-3-phosphate dehydrogenase 9
prostacyclin synthase 9
hyaluronidase 9
ascorbate peroxidase 9
proteasome 9
glyceraldehyde-3-phosphate dehydrogenase 9
hexokinase 9
AMP-activated protein kinase 8
CYP3A4 8
adenosine kinase 8
indoleamine 2,3-dioxygenase 8
hyaluronidase 8
demethylase 8
isocitrate dehydrogenase 8
dihydrofolate reductase 8
isocitrate dehydrogenase 8
plasmin 7
glyceraldehyde-3-phosphate dehydrogenase 7
RNase 7
RNase 7
calcineurin 7
peroxiredoxin 7
nucleotidase 7
thymidine kinase 7
ascorbate oxidase 7
glyceraldehyde-3-phosphate dehydrogenase 7
MPP 7
cholinesterase 7
prostaglandin synthetase 7
glyceraldehyde-3-phosphate dehydrogenase 7
endonuclease 7
kallikrein 6
caspase-9 6
amidophosphoribosyltransferase 6
thromboxane synthase 6
MAP 6
DNA ligase 6
invertase 6
phosphatidylinositol 3-kinase 6
DNA ligase 6
gamma-glutamylcysteine synthetase 6
beta-galactosidase 6
ADH 5
pyruvate dehydrogenase 5
deaminase 5
more...
Compound
oxygen 2951
hydrogen 965
H2O2 794
nitric oxide 691
Dec 598
iron 586
DNA 534
superoxide radical 475
sodium 423
calcium 381
water 380
Clin 371
HPP 342
GSH 331
GSH 331
molybdenum 318
glucose 305
NADPH 282
NADPH 282
phosphate 267
ATP 260
acetate 253
nitrogen 252
NADH 251
ethanol 250
arginine 209
aldehyde 199
potassium 192
cysteine 185
NAD 185
copper 181
EDTA 146
creatinine 146
EDTA 144
NAD 143
DPPH 133
acetaldehyde 126
ADP 125
nicotinamide 124
urea 122
nitrate 118
ADP 109
ADP 109
Xanthine 107
Uric acid 106
salt 102
Cardiol 99
sulfate 98
methanol 98
zinc 94
tyrosine 93
aldehyde 92
CO2 92
DMSO 87
TNF 86
cyanide 82
FAD 80
Phe 79
ethyl acetate 73
N-acetylcysteine 73
tungsten 72
manganese 71
caffeine 69
GSSG 69
AMP 67
PEG 67
glutamate 66
MDA 64
hydroxide 62
galactose 62
pyrimidine 60
pyrimidine 60
Hypoxanthine 56
chromate 55
cGMP 55
methionine 55
prostacyclin 52
ammonium 50
PMA 49
iodine 47
His 47
selenium 47
PMA 45
phenazine 45
phenol 44
bromide 43
SDS 43
diacetate 42
DFO 41
PEG 41
tryptophan 40
NADP 40
tryptophan 40
Oxypurinol 40
gallic acid 39
tryptophan 39
tryptophan 39
HCl 38
chloroform 38
NO3 38
Nitrite 36
thiourea 36
Malondialdehyde 36
leucine 36
alcohol dehydrogenase 36
hexane 35
kaempferol 35
Nitrite 35
NBT 34
Cu(II) 34
lysine 33
Tiron 30
Vitamin E 30
serine 30
cadmium 30
MTT 30
acetic acid 30
hydroxylamine 30
pyrene 29
benzene 29
Quercetin 29
hydroquinone 28
acetone 28
alanine 28
Adenosine 27
myricetin 27
alloxan 27
Ascorbic acid 27
GTP 27
cAMP 27
IMP 27
ammonia 26
CAT 26
CAT 26
CAT 26
formaldehyde 26
hydroxylamine 25
Adriamycin 25
NH2 25
formaldehyde 25
PGE2 24
benzoic acid 24
ACh 24
noradrenaline 23
pyridine 23
Melatonin 23
hyaluronic acid 22
8-OHdG 21
tert-butyl hydroperoxide 21
ADP-ribose 20
Indomethacin 20
Tris 20
Purine 20
cobalt 20
glycerol 20
Mannitol 19
Mannitol 19
5-HT 19
Hearts 19
salicylic acid 18
more...