Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.17.3.2 (xanthine oxidase)
 8,383 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

By means of Langendorff method the isolated rat heart was perfused with Krebs Henseleit solution. Following ligation of the left descending coronary artery for 10 min the heart was reperfused for 3 min. The incidence of ventricular fibrillation in the reperfusion period was 100%, and the normal sinus rhythm time was shortened to 29 s within 3 min of reperfusion. Administration of lipoic acid (6.8 X 10(-6)-1.7 X 10(-4) mol/L) to the perfusate significantly reduced the incidence of ventricular fibrillation to 33-50% and prolonged the normal sinus rhythm time to 97-107 s. APA, RP, and Vmax recorded from the guinea pig papillary muscle were depressed due to the deleterious effect of xanthine oxidase and hypoxanthine free radical generating system. Under the treatment of lipoic acid (3.5 X 10(-5) mol/L), the depression of APA, RP, and Vmax were significantly relieved. This confirms that lipoic acid treatment, owing to its free radical scavenger effect, is able to protect myocardium from free radical induced electrophysiological abnormalities, and consequently decrease the incidence of malignant arrhythmias.
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PMID:[Effects of lipoic acid on reperfusion induced arrhythmias and myocardiac action potential alterations induced by free radical generating system]. 206 84

The paper deals with the mechanisms responsible for formation of active oxygen forms and with the physiological and toxic aspects of their action on the cell. The active oxygen forms are essential biological energy metabolites, such as mitochondrial respiration and microsomal oxidation. It considers the specific features of the systems of APA by various cells (neutrophils, lymphocytes, fibroblasts, endothelial cells). The results of their authors' own investigations provide evidence for the concept that there is an oxidative damage to hepatocytes in liver damage, which is associated with activation of phagocytes, conversion of xanthine oxidase, inhibition of superoxide dismutase and catalase activity and accumulation of active oxygen forms.
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PMID:[Intracellular oxygen activation and molecular mechanisms of oxidative hepatic damage]. 751 22