Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.17.3.2 (
xanthine oxidase
)
8,383
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We investigated the influence of CIM and
HIS
on the SUP and CH in the SUP generating cell-free
xanthine oxidase
system and in human neutrophils. As measured by CCR or CH, we found that
HIS
inhibited SUP output in both systems. The
HIS
concentration required for a measurable inhibition was somewhat higher in the
xanthine oxidase
system than in neutrophils. CIM increased CH in neutrophils significantly. A similar effect of CIM was not observed in the
xanthine oxidase
system. CIM antagonized in neutrophils the effect of
HIS
. However, a five or ten times higher molar concentration of CIM than of
HIS
was necessary to produce this effect. The antagonistic effect of CIM was not found in the
xanthine oxidase
system within the concentrations applied. In addition to an interaction of
HIS
with neutrophils on the cellular level, we suggest a superoxidase scavenging effect caused by
HIS
. At the present no suggestions can be made regarding the observed SUP output stimulating activity of CIM.
...
PMID:Interaction of cimetidine and histamine with superoxide generated in a cell-free system and in neutrophils. 303 67
