Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.17.3.2 (xanthine oxidase)
 8,383 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the present study, the ocular inflammatory response to intravitreally injected endotoxin and xanthine oxidase was studied and the cellular response of the anterior and posterior segments was contrasted. There was a clear dose response relationship to both compounds in aqueous humor protein concentration and aqueous and vitreous humor white cell number. Xanthine oxidase and low doses of endotoxin (0.25 and 1.0 ng) produce a mainly mononuclear response in the anterior segment. Higher doses of endotoxin (10 and 100 ng) produced a predominantly neutrophilic response. Cellular infiltration into the posterior segment differed qualitatively and quantitatively from the anterior segment in response to the same stimuli. Myeloperoxidase (MPO) activity (a marker for neutrophils) of the iris-ciliary body was increased only in those eyes with a large neutrophilic response and thus is not recommended for use as a definitive index of the ocular inflammatory response, but may be a useful adjunct for such studies.
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PMID:Cellular response to intravitreal injection of endotoxin and xanthine oxidase in rabbits. 152 15

The potential of ascorbic acid acting against the toxic effects of active oxygen species on the lens has been studied. The active species of oxygen were generated by the action of xanthine oxidase on xanthine. Rat lenses incubated in medium containing xanthine and xanthine oxidase were physiologically damaged, as evidenced by the decrease in the ability of the tissue to accumulate rubidium or alpha-aminoisobutyric acid against a concentration gradient. The pressure of ascorbate in the medium protected against the tissue damage. One of the functions of high ascorbate in the aqueous humor of many primates including human beings may, therefore, be to protect the lens and other surrounding tissues against the toxic effects of active oxygen derivatives produced in situ under ambient, as well as under photochemical, conditions.
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PMID:In vitro damage to rat lens by xanthine-xanthine oxidase: protection by ascorbate. 381 25