Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.17.3.2 (
xanthine oxidase
)
8,383
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Xanthine oxidase deficiency was identified in a 16-year-old girl with acute lymphocytic leukemia (ALL). Despite the
enzyme deficiency
, the patient tolerated high doses of 6-mercaptopurine (6-MP), a drug which is normally inactivated by the action of
xanthine oxidase
. This rate clinical situation may be analogous in the practice to that of the patient receiving 6-MP who is also given allopurinol, which inhibits
xanthine oxidase
activity. The implications of these observations on the determination of appropriate drug dosages for patients receiving these two agents are discussed.
...
PMID:Acute lymphocytic leukemia in a child with congenital xanthine oxidase deficiency: implications for therapy. 694 80
