Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:1.17.3.2 (xanthine oxidase)
 8,383 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Serum xanthine oxidase activity was measured by a radiochemical method in 137 consecutive patients with jaundice of varying etiology and in 40 non-jaundiced patients with liver or other disease. Serum xanthine oxidase was markedly increased, up to 50 times the upper normal limit (mean + 2 S.D.), in 32 out of 34 patients with infectious hepatitis. A slight elevation of serum xanthine oxidase, up to twice the upper normal limit, was found in 2 out of 49 patients with extrahepatic obstructive jaundice and in 4 out of 20 patients with chronic renal failure. In comparison to serum glutamic-oxaloacetic transaminase and lactate dehydrogenase serum xanthine oxidase appeared to be the more sensitive and specific indicator of acute hepatocellular damage.
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PMID:Serum xanthine oxidase in jaundice. 118 Oct 72

Lantana poisoning has been taking a heavy toll of livestock year after year. All aspects of the problem are reviewed. Lantana poisoning in cattle, sheep, buffalo, and guinea pigs caused obstructive jaundice, photosensitization, and rise in serum glutamicoxaloaetic transaminase activity. The symptoms could be reproduced in sheep by administration of purified Lantadene A. Liver and kidneys are the most affected organs during lantana poisoning. Intoxication of guinea pigs with Lantana camara leads to marked alterations in major tissue constituents in liver an kidneys. Hepatic and renal xanthine oxidase activity is also elevated during lantana poisoning. No antidote is available against the toxic section of Lantana camara. Symptomatic treatments have been proposed with limited success. Knowledge of the biochemical mechanism of lantana intoxication at the cellular, subcellular, and molecular levels is essential in order to evolve a successful antidote and more rational therapy during lantana intoxication.
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PMID:A review of the toxicity of Lantana camara (Linn) in animals. 703 35