Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
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Gene/Protein
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Target Concepts:
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Query: EC:1.17.1.4 (
xanthine dehydrogenase
)
1,236
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Caenorhabditis elegans mechanoreceptors located in
ASG
sensory neurons have been found to sense ambient temperature, which is a key trait for animal survival. Here, we show that experimental loss of
xanthine dehydrogenase
(XDH-1) function in AIN and AVJ interneurons results in reduced cold tolerance and atypical neuronal response to changes in temperature. These interneurons connect with upstream neurons such as the mechanoreceptor-expressing
ASG
. Ca
2+
imaging revealed that
ASG
neurons respond to warm temperature via the mechanoreceptor DEG-1, a degenerin/epithelial Na
+
channel (DEG/ENaC), which in turn affects downstream AIN and AVJ circuits. Ectopic expression of DEG-1 in the ASE gustatory neuron results in the acquisition of warm sensitivity, while electrophysiological analysis revealed that DEG-1 and human MDEG1 were involved in warm sensation. Taken together, these results suggest that cold tolerance is regulated by mechanoreceptor-mediated circuit calculation.
...
PMID:The mechanoreceptor DEG-1 regulates cold tolerance in Caenorhabditis elegans. 3200 2
