Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:1.16.3.1 (ceruloplasmin)
 5,074 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Studies on the effect of increasing protein levels in the diet (0 to 50% casein) on hematological criteria (v. Krziwanek et al., 1978) were supplemented by experiments regarding the reaction of catalase, ceruloplasmin and alkaline phosphatase under such conditions. A relationship was found between the activity of all 3 enzymes and protein supply. The catalase activity of the blood revealed a linear relationship with the protein level of the diet. The activity of the alkaline phosphatase was found to go up as the protein level of the diet increased reaching its maximum with weight development. The ceruloplasmin activity revealed an opposite behaviour. The results show that the application of these criteria for measuring the supply with and conversion of trace elements do not allow reliable statements but under constant experimental conditions. The catalase activity in the blood may give certain clues for assessing the quality and quantity of protein in the feed.
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PMID:[Effect of various protein levels in the diet on the activity of some metalloenzymes]. 55 78

Plasma taurine and serine decrease following trauma and in severe inflammatory disease. These changes may signify an increase in requirements for sulfur amino acids. We previously demonstrated that cysteine supplementation can restore the impaired ability of rats fed an 8% casein diet to increase hepatic zinc, glutathione (GSH) and protein concentrations in response to tumor necrosis factor alpha (TNF alpha). Here we examined whether serine or taurine produces a similar effect, because serine provides the carbon skeleton of cysteine and taurine is its major metabolite. After 7 d of receiving either a 20% casein diet supplemented with cysteine or an 8% casein diet supplemented with alanine, serine or taurine, rats received an intraperitoneal injection of human TNF alpha. Tumor necrosis factor caused no change in hepatic GSH but resulted in a lower GSH concentration in lung in rats fed the alanine-supplemented diet. Neither taurine nor serine increased liver GSH relative to that in rats fed alanine, but the depression in lung due to TNF injection was lessened. The absolute increase in ceruloplasmin in response to TNF was enhanced in rats fed the alanine-supplemented diet relative to those fed the 20% casein diet. Serine normalized this response. This observation--the effects of taurine and serine on lung GSH and a significant negative correlation between ceruloplasmin and liver and lung GSH concentration in rats fed TNF--suggests that supplemental serine and taurine may improve antioxidant defenses when dietary supplies of cysteine are low but do not influence cysteine availability for a normal response to TNF.
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PMID:Taurine and serine supplementation modulates the metabolic response to tumor necrosis factor alpha in rats fed a low protein diet. 137 44

The genetic polymorphism of haemoglobin, transferrin, amylase, alkaline phosphatase, ceruloplasmin, beta-lactoglobulins and casein were studied. The relationship between the level of the heterozygosity of the blood polymorphic protein and enzyme systems was determined.
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PMID:[Genetic polymorphism of hemoglobin, protein systems, blood enzymes and their relationship to reproducibility]. 161 58

An experiment was conducted with growing rats to investigate the effects of feeding excessive specific L-amino acids for 8 days on serum and tissue cholesterol, alpha-tocopherol, ascorbic acid, and copper, and on liver microsomal cytochrome P-450. To a 10% casein diet were added 4% L-methionine, 5% L-cystine, 5% L-histidine, 5% L-threonine, 5% L-tryptophan, 5% L-phenylalanine, 5% L-tyrosine, 6% L-valine, 7% L-isoleucine, 7% L-lysine, or 8% L-leucine. Excessive cystine and histidine increased serum cholesterol and alpha-tocopherol. Excessive cystine and methionine increased liver and kidney alpha-tocopherol and ascorbic acid. Excessive tyrosine and phenylalanine caused a marked increase in serum copper and ceruloplasmin activity, whereas excessive cystine, methionine, and histidine caused a decrease in the ceruloplasmin activity. Excessive histidine increased liver cytochrome P-450, whereas excessive tyrosine markedly decreased liver cytochrome P-450.
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PMID:Effects of dietary excess amino acids on the concentrations of cholesterol, alpha-tocopherol, ascorbic acid, and copper in serum and tissues of rats. 209 20

Special methods allowing usage of inadequate pedigrees were employed to examine linkage among the milk protein loci alpha s1-casein, beta-casein, chi-casein and beta-lactoglobulin, and the loci for serum amylase, ceruloplasmin and transferrin. Linkage was evident between the alpha s1-casein and beta-casein loci, the alpha s1 and chi-casein loci, the beta-casein and chi-casein loci, also amylase and transferrin loci. Recombination fractions for these corresponding combinations were 0.00; 0.00; 0.00 and 0.30. Weak linkage (recombination fraction being 0.46; 0.44 and 0.42) between the beta-lactoglobulin and beta-casein loci, the amylase and ceruloplasmin loci, ceruloplasmin and transferrin loci is supposed.
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PMID:[Linkage relationship among loci determining genetic variants of serum and milk proteins in cattle]. 386 Apr 56

Acute-phase reactant proteins reach abnormally high levels in patients with cancer, and correlate with the extent of disease. In this study, several acute-phase glycoproteins, and serum albumin as a control, were tested at different concentrations for their ability to modify the blastogenic response of lymphocytes from 30 normal donors to PHA and the chemotactic response of monocytes from 15 normal donors to casein. In high concentrations approximating those found in cancer patients, but not in normal concentrations, haptoglobin and fibrinogen inhibited both functions to different degrees. Orosomucoid inhibited only monocyte chemotaxis, while ceruloplasmin and alpha 1-antitrypsin affected neither function. Increasing concentrations of PHA did not overcome the blocking effect of haptoglobin and fibrinogen on blastogenesis, suggesting that PHA-protein interaction was not responsible for the effect observed. The three proteins that did not suppress blastogenesis individually did so strongly when combined. It is suggested that these glycoproteins, synthesized by the liver in response to an inflammatory stimulus, may act as 'non-specific blocking factors' protecting tumors against the host's immunological attack. This non-specific blocking activity of the acute-phase proteins may contribute to the 'immune escape' of the tumor.
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PMID:Immunosuppressive effect of acute-phase reactant proteins in vitro and its relevance to cancer. 698 54

To investigate the potential effects of maternal infection during lactation on breast-milk quantity and composition, we examined low-income Peruvian women who had an acute febrile infection and were exclusively breast-feeding a child from 1 to 6 mo of age (n = 36). Women who were not ill (n = 38) served as controls; all women had body mass indexes (in kg/m2) > 19.5. Blood and milk samples were collected on days 1, 7, and 14 after identification of the episode of illness. C-reactive protein in maternal serum was significantly elevated by infection, whereas two other acute-phase reactants, ceruloplasmin and alpha 2-macroglobulin, showed no change. Serum zinc concentrations were significantly lower in ill women than in women who were not ill, whereas serum copper concentrations were elevated initially in ill women. Serum iron concentrations increased significantly with time, but there was no significant difference between groups. Milk intake, as assessed by 12-h test-weighing, was not affected by the infection. Concentrations of milk total protein, casein, and whey proteins were similar in the two groups and there was no significant effect of illness on milk trace element concentrations. Thus, acute maternal infections during established lactation did not affect milk volume, milk protein, or trace element concentrations, despite expected changes in serum protein and trace element concentrations.
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PMID:Effect of acute maternal infection on quantity and composition of breast milk. 766 Nov 17

The present study was conducted with growing rats to examine effects of addition of 0.3, 1.0, 2.5, and 5% L-cystine to 10 or 25% casein diet on tissue ascorbic acid and on serum cholesterol, alpha-tocopherol, and ceruloplasmin activity. Addition of 0.3-1% cystine to 10% casein diet caused the maximum growth and addition of 5% cystine to 25% casein diet depressed the growth. Increases in liver levels of ascorbic acid and in serum levels of cholesterol and alpha-tocopherol were observed with addition of 5% cystine to 10 and 25% casein diets as compared to the diets without addition of cystine. Addition of 0.3-5% cystine to 10% casein diet and addition of 5% cystine to 25% casein diet caused a decreased activity of serum ceruloplasmin. The changes in liver ascorbic acid, serum cholesterol, and serum alpha-tocopherol and in ceruloplasmin activity by dietary cystine correlated with the changes in liver levels of non-protein sulfhydryl.
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PMID:Responses of tissue ascorbic acid and of serum cholesterol, alpha-tocopherol, and ceruloplasmin in rats to dietary level of cystine. 812 Jun 73

Purified diets deficient in copper and based on either sucrose, egg white, and corn oil or sucrose, casein, corn starch, and safflower oil were fed to young rats. Graded amounts of copper were supplied in drinking solutions with the former diet and by addition to the latter diet; anatomical, chemical, and physiologic responses were compared. Three micrograms Cu/ml and 5 micrograms Cu/g were sufficient to maximize the direct assessments of copper nutriture (copper in blood plasma, heart, and liver). Nutritional adequacy by indirect criteria (heart iron, plasma ceruloplasmin, heart weight divided by body weight, plasma cholesterol, and body weight) generally was found with 3 micrograms/ml and 4 micrograms/g. Anemia was an insensitive characteristic of deficiency. Liver iron was minimized by 4 micrograms Cu/ml and 5 micrograms Cu/g. Most of the differences in response to copper added to water in comparison to copper added to diet probably were explained by the lower amount of copper in the casein diet. Responses to the two dietary regimens were similar when variables were plotted against liver copper. Correlation coefficients with liver copper ranged from 0.52 for liver zinc to 0.96 for heart iron. Liver copper probably is the best index of copper nutriture.
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PMID:Comparative responses of rats to different copper intakes and modes of supplementation. 850 63

We previously observed a rapid reduction in plasma ceruloplasmin activity in lean Zucker (Fa/Fa) rats fed a marginal copper (Cu)-deficient diet compared to similarly fed obese Zucker (fa/fa) and lean Sprague-Dawley rats. In an effort to understand the mechanisms underlying this response, we utilized the isotope dilution method to investigate the absorption and excretion of Cu in lean Zucker rats fed control and marginal Cu diet. Sprague-Dawley (SD) and homozygous lean Zucker rats were fed either a Cu-adequate (Cont; 7.5 micrograms Cu/g diet) or a low Cu (Low; 1.1 micrograms Cu/g diet) casein-based diet for 23 d. Two weeks following initiation of the dietary treatment, each rat was injected intramuscularly (im) with 11.2 microCi of 67Cu. Urine and feces were collected daily. On the 9th d following isotope injection, rats were killed and tissues collected. Significant dietary effects were observed in the relative absorption and endogenous fecal excretion of 67Cu. The tissue distributions of nonisotopic Cu and 67Cu activity were also different between dietary treatments. Tissues from rats fed the low-Cu diet typically had high concentrations of 67Cu and low concentrations of nonisotopic Cu compared to controls. An increase in relative 67Cu absorption was evident for rats fed the low-Cu diet (57.2 and 39.3%, for SD Low, Zucker Low, respectively, and 17.9, and 28.5% SD Cont and Zucker Cont, respectively). Rats fed the low-Cu diet also had reductions in endogenous fecal excretion of 67Cu compared to their respective controls. Although strain effects were not evident for either percent Cu absorption or endogenous fecal Cu excretion, the relative adaptive changes appeared more marked for the Sprague-Dawley rats compared to the lean Zucker rats.
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PMID:Copper absorption, endogenous excretion, and distribution in Sprague-Dawley and lean (Fa/Fa) Zucker rats. 886 55


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