Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:1.16.3.1 (ceruloplasmin)
 5,074 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Bromfenvinphos [0,0-diethyl-1-(2,4-dichlorophenyl)-2-bromovinyl phosphate], (BrV), 12.33 mg/kg/day alone and in combination with methoxychlor [1,1,1-trichloro-2,2-bis(4-methoxyphenyl)ethane], (MeOCl), 24.66 mg/kg/day were administered daily per os (intragastrically) in pure olive-oil for 6 weeks to male laboratory mice. The activity of gamma-glutamyl transpeptidase (GGTP), ceruloplasmin (CRP), and cholesterol in the blood plasma were determined. The hematocrit value, the erythrocyte count and the weights of the liver, spleen, heart, kidney and gonads were also measured after the end of treatment. BrV and BrV + MeOCl increased the activity of gamma-glutamyl transpeptidase. The activity of ceruloplasmin and the level of cholesterol in the blood plasma as well as the erythrocyte count in the blood were also similar in the control and experimental mice. The hematocrit value decreased after BrV and MeOCl administration. The relative weight of liver was higher in mice receiving both drugs in combination, than in control and in mice receiving BrV alone. The relative weight of spleen was significantly higher in animals receiving BrV alone, than in other groups.
Pol J Pharmacol
PMID:Influence of bromfenvinphos alone, and in mixture with methoxychlor, on levels of gamma-glutamyl transpeptidase, ceruloplasmin and cholesterol in the blood plasma of laboratory mice. 810 90

Copper constitute one of the most significant trace metal for the organism. Numerous biochemical processes depend on this element. It constitute component and activator of many enzymes. In blood serum copper is bound with ceruloplasmin. In this work the behavior of copper and ceruloplasmin concentration in blood serum in the course of pneumonia in infant was investigated. 36 infants aged 2 months trough 12 months with pneumonia were included in the study. The control group consisted of 14 healthy infants. Tests were conducted thrice in the group of sick infants. In the acute stage of pneumonia in sick infants the authors showed higher copper and ceruloplasmin concentration values. After the therapy ended the concentration of those values were similar to those in the control group.
Pneumonol Alergol Pol 1995
PMID:[Copper and ceruloplasmin concentrations in serum of infants with pneumonia]. 852 May 53

In this study we examined selected elements of the antioxidant defence system in the plasma of children with the most common solid tumors (nephroblastoma, neuroblastoma, rhabdomyosarcoma, osteosarcoma). We observed a significant increase of plasma antioxidant activity (AOA) in the majority of the examined children. This factor changed during clinical treatment, i.e. induction of chemotherapy, surgery and/or radiotherapy and during maintenance chemotherapy. We conclude that the elevated plasma antioxidant activity in children with malignancy may be due to the higher concentration of ceruloplasmin in affected children than in their healthy counterparts.
Pediatr Pol 1995 Nov
PMID:[Blood antioxidant defense in children with malignant disease. I. Plasma antioxidant activity and level of ceruloplasmin and transferrin]. 867 54

The case of atypical course of Wilson's disease in a 31 years old woman was reported. Basing on its clinical presentation it was classified as a liver form. The laboratory criteria necessary for the diagnosis of this disease are as follows: increase of cooper concentration in liver tissue (above 500 micrograms copper per gram dry substance), defect of copper incorporation into ceruloplasmin in 24 hours copper excretion test in urine (above mumol/24 h). In this report the main principles of pharmacotherapy were summarized, with particular stress on the necessity throughout the patient's life.
Pol Merkur Lekarski 1996 Sep
PMID:[A case of Wilson's disease with an atypical clinical course]. 913 91

Sixty two samples of amniotic fluid were submitted to biochemical investigation including 31 samples from women with pregnancy complicated by hypertension (studied group with blood pressure -65 +/- 15/95 +/- 5 mm Hg) and 31 samples deriving from healthy pregnant women (control group with mean blood pressure 118 +/- 10/74 +/- +/- 9 mm Hg). The following parameters of amniotic fluid were measured: 1) aminotransferases: alanine AlAT and aspartate AspAT, 2) alkaline phosphatase (APt) and its thermostable isoenzyme (APh), 3) ceruloplasmin (Crlp), 4) alpha-amylase (alpha-Amy). The study showed pregnancy complicated by hypertension is related to fetal salivary gland's immaturity presenting decreased activity of alpha amylase in amniotic fluid. Amniotic fluids deriving from women with pregnancy complicated by hypertension showed normal activities of AlAT, AspAT, APt, APh and Crlp.
Ginekol Pol 1996 Dec
PMID:[Evaluation of fetal condition in pregnancy complicated by hypertension--biochemical assessment of amniotic fluid. II. Enzymes]. 928 52

According to Ravin's method an oxidative activity of ceruloplasmin was determined in the group of patients with carcinoma of larynx before and after rtg-therapy and at the control group of healthy individuals. As a result of this assay the significantly increased of oxidative activity ceruloplasmin was obtained in the individuals with the carcinoma of the larynx before rtg-therapy in comparison to the group of healthy subjects. Simultaneously a significant decrease of the oxidative activity of serum ceruloplasmin in the individuals with carcinoma of the larynx after rtg-therapy was observed.
Otolaryngol Pol 1997
PMID:[Oxidase activity in patients with laryngeal carcinoma treated by radiotherapy]. 975 22

Wilson's disease is a rare, multiorganic genetically coded disorder, induced by impaired copper transport. The recent identification of the disease gene and the discovery of gene product--copper transporting P-type ATPase that is integrate membranous protein has contributed greatly to better understanding of the pathogenesis. This protein is probably essential for incorporation of copper into ceruloplasmin and for its biliary excretion. Multiple mutations of Wilson's disease gene are responsible for the excess of so called "free" copper which is toxic to tissues. Copper toxicity involves first of all, functional disorders of many enzymatic systems, particularly those of respiratory chain enzymes. In the central nervous system, a special kind of copper toxicity is medicated by astroglia, so that a direct, harmful effect of both copper and ammonia on the brain is observed. The authors present a current review on biochemical mechanisms of copper toxicity and physiopathological significance of the CNS astroglia in Wilson's disease.
Neurol Neurochir Pol
PMID:[Modern views on the pathogenesis of Wilson's disease]. 976 May 55

The authors present a very rare case of Holmes tremor (previously known as rubral or midbrain tremor). In all described till now cases the tremor was due to a known and revealed in laboratory or neuroimaging cause. We present an unusual case of a 42-year old woman with unilateral tremor of right extremities (mostly proximal part of upper extremity) which started abruptly 3 years ago. She had no suffer any serious disease before the onset of symptoms and her family history was also negative. The tremor was present at rest but accelerated during specific postures and active movements. The laboratory tests including: copper and ceruloplasmin concentrations, blood analysis for acanthocytes, evoked potentials, EEG, CT, MRI, MRA and SPECT did not reveal any significant changes. Treatment attempts with neuroleptics, clonazepam, L-dopa, valproic acid, biperiden were almost completely ineffective except local injections of botulinum toxin (Botox, Allergan, 150 U) into the muscles of right arm girdle which moderately alleviated tremor. We did not find any underlying pathology as a cause of tremor, clinically the same as symptomatic cases described in literature. We suggest the possibility of idiopathic origin of tremor in our case, although a very small size of lesion (f.i. ischaemic) could be undetectable in the described tests.
Neurol Neurochir Pol
PMID:[Rubral tremor of Holmes, rare case of pathological tremor: case report]. 1110 9

Antioxidant defences interact to form an integrated system. There is no comprehensive and uniform view on issues concerning the antioxidant status in horses. Therefore, the aim of the present study was to estimate antioxidant parameters in horses of different age, sex and breed as well as environment and relationship between different antioxidants. Parameters of selected antioxidants including superoxide dismutase (SOD), glutathione peroxidase (GSH-px), total antioxidant status (TAS), ceruloplasmin (CP), bilirubin, uric acid, zinc, copper and selenium were determined in blood of 80 clinically healthy horses. Antioxidant parameters significantly varied between horses form different environments or different breed and sex. Age of horses had no significant effect on antioxidant parameters. Significant correlation coefficients were observed between enzymatic and nonenzimatic antioxidants. The nature of the relationship between the antioxidant system in horses with respect to environmental factors is rather complex and to date only a part of system is known.
Pol J Vet Sci 2002
PMID:Antioxidant parameters of horses according to age, sex, breed and environment. 1251 52

Our preliminary study shows that an oral administration of an aqueous extract of Casearia esculenta, an indigenous antidiabetic plant popularly used in South India for diabetes mellitus, lowers blood glucose level under normal and glucose load conditions, and in streptozotocin (STZ)-induced diabetes in rats. The study was further undertaken to evaluate the antioxidant potential of C. esculenta in STZ diabetic rats. Oral administration of C. esculenta root extract at doses of 200 and 300 mg/kg for 45 days resulted in significant reduction in plasma thiobarbituric acid reactive substances (TBARS), hydroperoxide and ceruloplasmin and a significant elevation in plasma reduced glutathione (GSH), ascorbic acid (vitamin C) and alpha-tocopherol (vitamin E). The study indicates that C. esculenta root extract at doses of 200 and 300 mg/kg restored all the antioxidant parameters to near normal value.
Pol J Pharmacol
PMID:Effect of Casearia esculenta root extract on blood glucose and plasma antioxidant status in streptozotocin diabetic rats. 1285 25


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