Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:1.16.3.1 (ceruloplasmin)
 5,074 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The interrelationship between erythropoiesis activity and the dynamic of copper metabolism in normal rats and the rats with experimentally induced anemia and polycythemia was studied, using 64Cu injected intravenously in the form of CuCl2. The studies demonstrated that the copper metabolism is different in erythropoiesis stimulation and inhibition. Significant changes in the plasma ceruloplasmin level and the plasma copper content as well as in the plasma copper clearance and blood copper turnover were observed.
Acta Physiol Pol
PMID:Copper metabolism in different states of erythropoiesis activity. 74 9

A rapid and simole procedure for isolation of ceruloplasmin from porcine and bovine blood sera was elaborated; it involves DEAE-Sephadex A-50 chromatography, precipitation with an ethanol-chloroform mixture plus extraction with saline, and preparative polyacrylamide-gel electrophoresis. The preparations obtained showed a high degree of electrophoretic homogeneity and a higher A610/A280 ratio and specific activity than the preparations obtained by the modified method of Broman & Kjellin (Biochem. Biophys. Acta, 82, 101-109, 1964).
Acta Biochim Pol 1978
PMID:A simple and rapid procedure for isolation of ceruloplasmin from porcine and bovine blood serum. 75 62

According to Ravin's method an oxidative activity of ceruloplasmin was determined in the group of patients with carcinoma of the larynx before and after a surgical treatment, in the group of patients with inflammatory lesions in the upper respiratory tract and in the control group of healthy individuals. As a result of this assay the significantly increased of oxidative activity ceruloplasmin was obtained in the individuals with the carcinoma of the larynx (before surgical treatment) in comparison to the group of patients suffering due to inflammatory diseases of the upper respiratory tract and to the group of healthy subjects. Simultaneously a significant decrease of the oxidative activity of serum ceruloplasmin in the individuals with carcinoma of the larynx after a previous surgical treatment was observed.
Otolaryngol Pol 1992
PMID:[Determination of oxidative activity of ceruloplasmin using Ravin's method in patients with laryngeal carcinoma]. 143 72

The ceruloplasmin activity of serum was measured in 50 patients with larynx cancer and 50 healthy subjects. The determination of serum ceruloplasmin based on the diamine oxidase activity with o-dianisidine as a substrate. In patients with laryngeal cancer the ceruloplasmin activity was significantly higher than that in healthy controls. The increase in the ceruloplasmin activity was correlated with clinical stage of larynx cancer.
Otolaryngol Pol 1992
PMID:[Serum ceruloplasmin activity in patients with cancer of the larynx]. 150

In various anaemias the values of 8 acute phase factors were determined simultaneously before and at the end of treatment: seromucoid, sialic acid, acid alpha 1-glycoprotein, alpha 1-antitrypsin, haptoglobin, ceruloplasmin, transferrin and fibrinogen. In iron-deficiency anaemia without coexistent inflammatory changes in organs the levels of 4 proteins--seromucoid, alpha 1-antitrypsin, ceruloplasmin and transferrin, were consistently raised. In iron-deficiency anemia with concomitant infection 4 proteins also were increased, but in place of alpha 1-antitrypsin the haptoglobin level was raised. In megaloblastic anaemia the ceruloplasmin level was increased, and in haemolytic anaemia one factor--sialic acid--was decreased. At the end of treatment the concentrations of certain proteins were changed depending on their specific role in various forms of anaemia and on various additional factors. In iron-deficiency anaemia without coexistent infection the concentration of seromucoid was decreased, and in this anaemia with coexistent infection alpha 1-antitrypsin, haptoglobin, and fibrinogen levels were raised, in haemolytic anaemia only fibrinogen was increased, and megaloblastic anaemia was associated with raised seromucoid level. The therapeutic result was good in all these anaemias with the exception of iron-deficiency anaemia associated with infection in which it was less propitious.
Acta Haematol Pol 1991
PMID:[Acute phase factors in anemia]. 172 69

The effect of ceruloplasmin on the peroxidation of blood platelet lipids was tested. Using thiobarbituric acid reactivity for measuring lipid peroxidation it was shown that ceruloplasmin inhibited peroxidation of pig platelet lipids induced by UV-irradiation, and much less when enzymatic peroxidation was stimulated by thrombin.
Acta Biochim Pol 1990
PMID:Protective effect of ceruloplasmin against lipid peroxidation in blood platelets. 207 84

Immunological studies were carried out in 85 male smokers smoking 15-25 cigarettes daily for 2-25 years, and in 49 non-smokers. Cigarette smoking for a period longer than 10 years caused a fall of IgA, IgG, IgM and lysozyme concentrations. On the other hand, the levels of C3c and C4 components of complement, alpha 1-acid glycoprotein, ceruloplasmin, haptoglobin and antistreptolysin O were normal. Impairment of immunity to infections and neoplasms in cigarette smokers may be related to deficiency of various proteins responsible for normal course of immune processes of the organism.
Pol Arch Med Wewn
PMID:[Indicators of humoral immunity and acute phase reaction in cigarette smokers]. 212 45

In 45 patients suffering from acquired valvular heart disease (a.v.h.d.) and in 20 controls blood serum levels of copper (Cu2+), ceruloplasmin (Clp), hydroxyproline (Hypro), hydroxylisine (Hyliz), collagen-like protein (Col-p), and daily urine excretion of Cu2+, Hypro, Hyliz and glycosamino-glicans (GAG) were determined. The comparison of the obtained mean values has shown that blood serum levels of Cu2+, Clp, Hypro, Hyliz, Col-p in the studied patients were statistically significantly higher than those found in controls, and the values of daily urine excretion of Cu2+, Hypro, Hyliz, GAG behaviour were similar. There were no significant differences between active and inactive processes and between infective and rheumatic endocarditis excluding GAG urine excretion. These elevated collagen degradation products provide evidence for disturbed collagen metabolism and confirm our previous biochemical, histopathological and ultrastructural examinations of connective tissue in patient with a.v.h.d. They also indicate that general collagenopathy might be the primary cause of a.v.h.d.
Mater Med Pol
PMID:Investigations upon collagen metabolites in blood serum and urine of patients with acquired valvular heart disease. 249 Dec 71

The aim of this paper was to investigate the action of copper on some biochemical parameters of blood of Wistar rats exposed to a combined action of lead and ethanol. The animals received lead in drinking water (500 micrograms/ml) for 6 weeks, followed by copper (12 micrograms/ml) for 2 weeks. During the last 108 h of the experiments the rats received every 12 h an intragastric dose of 5g/kg of ethanol. In rats receiving copper together with ethanol the blood levels of copper, iron and lead were higher than in the rats receiving copper alone, the total and latent iron binding capacity were depressed, the transferrin saturation with iron was increased and the ceruloplasmin content--decreased. Copper protected rats against the action of lead on the following hematologic parameters: hemoglobin concentration, hematocrit, iron concentration, total and latent iron binding capacity, transferrin saturation index, copper concentration and ceruloplasmin activity. Ethanol administration counteracts the protective effect of copper on iron concentration, total and latent iron binding capacity, transferrin saturation index and ceruloplasmin serum content.
Pol J Pharmacol Pharm
PMID:The interactions of copper, lead and ethanol in rats: effects on some biochemical parameters of blood. 261 86

The study was carried out on 23 samples of amniotic fluid taken (by amniocentesis) between 35th and 39th week from pregnant women with arterial hypertension (13 cases of hypertension induced by pregnancy, 5 cases of primary hypertension and 5 cases of hypertension accompanying renal diseases). Seven women undergoing the study gave birth to newborns with symptoms of delayed intrauterine growth below 16 centiles (group examined), 16 mothers gave birth to eutrophic babies (control group). The amniotic fluid of the two groups was studied for the following biochemical indexes: alanine and aspartate aminotransferase alkaline total and thermostabile phosphatase, ceruloplasmin, alpha-amylase, general protein, beta-lipoproteins, cholesterol, uric acid, urea and creatinine. No significant changes were found in the parameters determined between the group examined and the control group.
Ginekol Pol 1989 May
PMID:[Biochemical studies of the amniotic fluid in arterial hypertension in relation to intrauterine growth retardation. I. Parameters of the proteins, lipids, enzymes and renal maturity]. 263 82


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