Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.16.3.1 (ceruloplasmin)
 5,074 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

I would like to comment on two points raised by Dr. Barbara Simcock in her 'Pitfalls in contraception' (AFP October 1978). IUD-associated fetal anomalies: There have been scattered reports about these, as Dr. Simcock remarks. Further, infants born in the presence of copper-containing IUDs have high serum levels of copper and ceruloplasmin. As copper is intimately involved in the metabolism of mitochondria, collagen and melanin the long term sequelae may be sinister. One case has been documented where high levels were the probable cause of still birth. IUD-associated infections: It is now well established that, apart from gonorrhoea, there is poor correlation between cervical swabs and pathogens higher in the genital tract. Thus the results of these swabs should not be relied on as a guide to treatment.
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PMID:Contraceptive pitfalls. 43 85

Copper contents (Cu) in bodies and serum ceruloplasmin (Cp) were assayed in patients with liver cirrhosis (LC) and hepatocarcinoma (HCC) with atomic absorption and other methods. The results were shown as follows: 1. The mean levels of serum Cp and urine Cu in LC were higher than those of normal (P < 0.05 and 0.01). 2. Serum Cu and Cp levels were consistently high in HCC. Urine Cu level was also elevated and had positive correlation with that of serum Cu (r = 0.567, P < 0.01). 3. Cirrhotic liver Cu content was almost the same as that of pericarcinomatous liver Cu, being higher than that of normal and carcinomatous liver. 4. Hair Cu level in both LC and HCC was apparently lower than that of normal subjects. 5. Serum Cu level in patients with tumor more than 5 cm in size was higher than that in patients with tumor less than 5 cm (P < 0.05). 6. Serum Cu level decreased along with the reduction of tumor size after treatment. 7. Serum Cu and Cp levels may be used as markers for detection of HCC, especially for AFP-negative HCC. Serum Cu estimation is valuable in assessment of the therapeutic effect and prognosis in patients with HCC.
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PMID:[The changes in copper contents and its clinical significance in patients with liver cirrhosis and hepatocarcinoma]. 807 Feb 91