Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: EC:1.16.3.1 (ceruloplasmin)
5,074 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

All seven pure yolk sac tumors of gonadal and extragonadal origin tested showed a bright positive fluorescence for alpha-fetoprotein in the tumor tissue. A positive reaction was seen in both the tumor cells and the hyaline globules. In all cases, however, the positive fluorescence was distributed in some focal areas of the tumor tissue. Certain tumor cells showed a strong granular intracytoplasmic fluorescence, whereas others showed a weak or a negative fluorescence. The fluorescence-positive tumor cells were located mainly in the areas rich in fluorescence-positive hyaline globules. Besides alpha-fetoprotein, certain plasma proteins--albumin, alpha-1 antitrypsin, and transferrin--were also demonstrated in all five yolk sac tumors tested. The pattern of the distribution of positive fluorescence was basically similar to that of alpha-fetroprotein. Other plasma proteins--orosomucoid, haptoglobin, Gc-globulin, alpha-2 macroglobulin, hemopexin, and ceruloplasmin--were present in certain tumors, and were distributed mainly in a limited number of hyaline globules. Both IgG and IgA were present in two tumors of ovarian origin. The immunoglobulins were for the most part present in extracellular hyaline globules, suggesting that these are taken up from the circulation. Test for fibrinogen, beta-lipoprotein, IgM, IgE, beta-1C/beta-1A and beta-1E globulins were negative or questionable. In a hepatoblastoma, tests for alpha-fetoprotein were positive, but those for other plasma proteins were negative. Fine granular fluorescence was seen in each hepatocellular tumor cell. Mesenchymal elements were virtually unstained.
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PMID:Immunofluorescent demonstration of alpha- fetoprotein and other plasma proteins in yolk sac tumor. 6 8

The intercalibration precision and linearity were determined for two representative analytes, apolipoprotein A1 (apo A1) and immunoglobulin G (IgG), on the Beckman Array and the Behring Nephelometer 100 (BN-100). For two of nine samples analyzed, poor precision was observed for IgG with the Array. The poor precision for these two samples is attributed to large systematic shifts. A statistical non-linearity was observed for apo A1 with the BN-100, but this non-linearity does not exclude use of this assay for clinical diagnosis. Method comparisons were done for 12 analytes: apo A1, apo B, IgG, IgA, IgM, IgE, C3, C4, albumin, C-reactive protein, alpha-1-antitrypsin, and ceruloplasmin. These comparisons showed proportional biases of > 10% for seven of 12 analytes. Furthermore, correlation coefficients were < 0.96 for seven of 12 analytes. We conclude that comparing results obtained from the two different nephelometers is of only limited value for the individual patient.
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PMID:Comparison of two automated nephelometers. 842 76

Non-specific immunological parameters were analysed in dependence of cigarette smoking. Although the serum protein levels were in the normal range, it was remarkable to find some differences between non-smokers, ex-smokers and (heavy) smokers. These differences are especially distinct in the mean levels of IgE, alpha 1 PI and ceruloplasmin.
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PMID:[Effect of smoking on immunologic parameters]. 209 43

The study comprised 40 children of both sexes aged from 2 to 12 years, 22 suffering from bronchial asthma and 18 suffering from atopic dermatitis. Twenty healthy children of comparable age and sex to the patients were studied as controls. All the children were subjected to full history including dietetic questionnaire, thorough examination, and to estimation of serum IgE, serum ceruloplasmin, and zinc and copper levels in both serum and hairs. The mean concentrations of zinc in serum and hairs were respectively 70.3 +/- 13.2 micrograms/100 ml and 167.5 +/- 23.0 micrograms/gm in asthmatic cases and 65.9 +/- 11.7 micrograms/100 ml and 164.8 +/- 23.6 micrograms/gm in those with atopic dermatitis. These levels were significantly (p less than 0.001) decreased in comparison to the control values (88.4 +/- 11.0 micrograms/100 ml and 194.5 +/- 18.6 micrograms/gm). On the other hand, a significant (p less than 0.001) increase in serum and hairs copper was demonstrated in both allergic groups compared to the controls. Mean copper values were respectively 79.5 +/- 8.06 micrograms/100 ml and 18.7 +/- 1.9 micrograms/gm in the asthmatic cases and 81.4 +/- 8.4 micrograms/100 ml and 17.8 +/- 2.08 micrograms/gm in cases with atopic dermatitis. The control mean concentrations were 67.95 +/- 6.37 micrograms/100 ml and 14.5 +/- 2.53 micrograms/gm respectively. Significant (p less than 0.001) higher levels of serum ceruloplasmin were observed in the allergic patients compared to the controls and were correlated with the hypercupremia. The results were discussed and a good dietetic intake of high biological value protein and zinc supplement was recommended to these patients in order to correct their disturbances especially the hypozincemia which could lead to exaggeration of their allergic conditions. The field of trace elements metabolism has grown rapidly over the past few years, particularly after the development of novel techniques as the atomic absorption spectrophotometry which had allowed the reliable measurements of several trace elements in tissues and so had opened a new field for many researches (Henkin, 1976). Zinc and copper are involved in cell and tissue growth. Zinc plays an important role in DNA and protein synthesis and is intimately involved with copper as cofactors in several important enzyme systems. The effects of many pathological conditions as congestive heart failure, pneumonia, rheumatic heart diseases, bronchitis, recurrent infection, hemolytic anemia, psoriasis, and malnutrition on the levels of serum zinc, copper, and other trace elements have been of interest to investigators for a number of years (Sinha and Gabrieli, 1970; David et al., 1984).(ABSTRACT TRUNCATED AT 400 WORDS)
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PMID:Zinc and copper status in children with bronchial asthma and atopic dermatitis. 213

In four areas with different types of atmospheric pollution 534 children of school age were examined for serum immunoglobulins (IgG, IgA, IgM and IgE), saliva IgA (sIgA), lysozymes (LYS) and acute phase reactants (alfa-l-antitrypsin - A1AT, alfa-2-macroglobulin -A2M, ceruloplasmin -CPL, transferrin - TRF). The children were divided into two groups: those with altered resistance (AR) comprising allergoses of all types and recurrent or persistent infections and those without the above health problems, i.e. healthy (H). There were more children with AR in areas with higher atmospheric pollution than in control areas. The frequency of AR was higher among boys than among girls. In the control area BN, a number of parameters in the AR group differed significantly from those in the H group. In areas with substantial atmospheric pollution these differences were generally less pronounced. Significant differences were found between the control and polluted areas in many indicators. In the area KO characterized by an intermediate degree of industrial pollution the means of the tested parameters were habitually elevated, whereas in the heavily polluted areas they were decreased. The most sensitive tests for evaluating differences between the areas were the levels of A1AT, LYS, and IgE, while the variations of sIgA, sLYS and CPL were less pronounced.
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PMID:Immunoglobulins and some serum proteins in children with altered resistance coming from areas with variously polluted atmosphere. 235 15

Blood serum levels of immunoglobulins (IgG, IgA, IgM, IgD, IgE), concentration of complement components (C1-inhibitor, C3, C4, C5, C9) as well as the content of some protein fractions (transferrin, ceruloplasmin, haptoglobin, orosomucoid, alpha 1-antitrypsin, alpha 2-macroglobulin, albumin and prealbumin) in the plasma were assayed in subjects exposed (due to their occupational necessity) to food raw materials (wheat, corn, barley, combined fodder) contaminated with mycotoxins. A total of 50 subjects, who have been working from 1 to 15 years at grain-treating factories, were investigated. It has been shown that a long-term exposure to food and fodder products containing mycotoxins induces a growth of IgE level attended by a drop in IgG content, and a decrease in the concentration of the complement components C3 and C9, transferrin and orosomucoid.
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PMID:[The immunological reactivity indices (the humoral component) in persons in contact with mycotoxin-contaminated food products]. 239 78

In autumn and spring a group of 132 ten-year-old school children (54.5% from families of smokers) were examined for blood content of immunoglobulins (IgG, IgA, (gM, in autumn including also IgE), lysozyme (LYS) and the so called acute reactants (alpha-1-antitrypsin = A1AT; alpha-2-macroglobulin = A2M; transferrin = TRF; ceruloplasmin = CPL); and for saliva sIgA and sLYS. Autumn examination detected significantly higher mean values of IgE in children from families of smokers, while other mean differences remained insignificant. Spring examination revealed significant differences in the means of IgA levels children from families of smokers (FS) had significantly lower levels of IgA while their saliva sIgA values were significantly higher. Mean spring CPL levels in FS were significantly higher. Analysis of distribution curves of autumn examination showed a significant shift of A1AT towards higher values in boys from FS. Girls from FS exhibited a shift of LYS towards lower values. Spring examination in boys FS evidenced a shift of CPL and sIgA values towards higher values; the curve of serum IgA levels split distinctly into two subgroups. In girls from FS the only change observed during the spring examination was a shift of A2M levels towards higher values with an indication of a split. To conclude, passive smoking in school children is responsible for a number of significant changes, the latter being more frequent and marked in spring when the children's organism is weakened by many other unfavourable circumstances. More significant changes were seen in boys.
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PMID:Humoral defending mechanisms in children of smoking parents. 244 22

A group of 85 patients with a minimal activity of rheumatic process received the diet with a high protein content (130 to 140 g). The effect of the high protein diet was evaluated according to the time-course of changes in the content of individual blood serum proteins (albumin, prealbumin, alpha1-antitrypsin, alpha2-macroglobulin, transferrin, ceruloplasmin, orosomucoid, fibrinogen, haptoglobin, IgG, IgM, IgA, IgD, IgE, complement components: C1-inhibitor, C3, C4, C5 and C9). It was revealed that the dietetic management brought about not only the improvement of the general status and reduction of the clinical manifestations of the disease but also exerted a favourable action on the concentration of serum proteins assayed.
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PMID:[Effect of dietotherapy on the blood serum protein content of patients with torpid and latent recurrent rheumocarditis]. 370 35

Thirty-eight production workers exposed to Ni and 35 exposed to Co were examined for the content of Ni and Co in hair, the serum concentration levels of immunoglobulins, IgG, IgA, IgM, and IgE, and serum proteins, alpha 2-macroglobulin (A2M), transferrin (TRF), alpha 1-antitrypsin (A1AT), ceruloplasmin (CPL), lysozyme (LYS), and alpha 1-glycoprotein (A1GP). Atomic absorption analysis of hair revealed that the respective geometric mean values of Ni and Co in Ni-exposed workers were 216.75 and 3.31 micrograms X g-1 and in Co-exposed workers 34.5 and 96.81 micrograms X g-1. These values were significantly higher than respective control values found in nonexposed individuals matched by age (Ni: 3.31 and Co: 0.38 micrograms X g-1). These findings suggest that hair analysis is a suitable method for the biological monitoring of exposure to these two metals. Tests for serum proteins revealed that nickel workers differed from controls by exhibiting significantly elevated IgG, IgA, and IgM levels; cobalt workers by a significant elevation of IgA level; and both exposed groups by a significant drop in the IgE level. A significant rise in the concentration (P less than 0.001-P less than 0.005) was also recorded in the case of A1AT, A2M, CPL, and LYS. The possible biomedical implications of these immunobiochemical findings are critically analyzed.
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PMID:Human exposure to nickel and cobalt: biological monitoring and immunobiochemical response. 373 11

The transport of immunoglobulins across the intestinal mucosa of neonatal rats provides an excellent model for the study of transcellular protein transport. The mechanism of intestinal uptake and transcellular transport of plasma proteins has been studied in 12-14-day old rats using intraduodenally administered radioiodinated proteins. Appreciable quantities of rat IgG, mouse IgG, rabbit IgG, and all four subclasses of human IgG were taken up by the intestinal wall (19-54% of administered dose at 4 hr) and transported to the animal (10-35% of administered dose at 4 hr). In contrast there was little or no uptake of human IgM, IgA, and IgE and little or no transport of human IgM, IgA, IgD, IgE, albumin, transferrin, and ceruloplasmin. Both the uptake and transport of labeled IgG were significantly inhibited by unlabeled IgG. Further insight into the transport process was obtained from the observation that an appreciable proportion of the label of IgG in intestinal wall homogenates, but not in plasma or intestinal washings, migrated in a sucrose ultracentrifugation gradient much more rapidly than did the administered 7S molecules. This pattern was not observed with other proteins studied. This apparent binding of labeled IgG was also markedly inhibited by unlabeled IgG. In subcellular fractionation studies of intestinal homogenates the complexed labeled IgG was shown to be associated predominantly with cell membrane rather than cell sap fractions. In addition IgG could be shown to bind to purified enterocyte microvillous membranes in vitro. IT IS CONCLUDED THAT IN THE NEONATAL RAT: (a) the major processes involved in both intestinal uptake and transport of IgG are specific and saturable; (b) intestinal transport is associated with complexing of IgG molecules with membranes, most probably with enterocyte microvillous membranes; and (c) the part of the IgG structure involved in this process is probably similar to that involved in the concentration-catabolism effect but is not identical to that mediating other non-antigen combining functions of IgG. Our data are consistent with the existence of specific receptors for IgG on enterocyte microvillous membranes of the neonatal rat. Such receptors would be necessary for the specific uptake and transport of these molecules.
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PMID:The mechanism of intestinal uptake and transcellular transport of IgG in the neonatal rat. 508 Apr 17


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