Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:1.16.3.1 (ceruloplasmin)
 5,074 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Blood specimens from 134 Oraon, a Dravidian-speaking tribe in Bihar, India, have been tested for haptoglobin, transferrin, ceruloplasmin, phosphoglucomutase, lactate dehydrogenase, albumin, and malate dehydrogenase types by starch gel electrophoresis. Low Hp1 and high TfD gene frequencies emerge.
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PMID:Serum protein and red cell enzyme polymorphisms in Oraon tribe, India. 105 51

Serum protein (albumin, haptoglobin, ceruloplasmin, transferrin and group-specific component), haemoglobin, and red cell enzyme (glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, acid phosphatase, esterase D, adenylate kinase, glyoxalase I, phosphoglucomutase, lactate dehydrogenase, malate dehydrogenase, phosphohexose isomerase and superoxide dismutase) polymorphisms were studied among the Bengali Muslims of Bangladesh. In general, the gene frequencies of the polymorphic systems were similar to those in West Bengal and Assam. There appears to be a relatively strong Mongoloid influence in the present population as evidenced by the presence of HbE and TfDChi, higher frequencies of Hp1 and GcIF, and a lower AK2 frequency.
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PMID:Blood genetic markers in Bengali Muslims of Bangladesh. 295 66

Five tribal populations, Koya Dora, Raj Gond, Naikpod, Pardhan, and Lambadi from Andhra Pradesh were examined for Tf, Hp, Gc, ceruloplasmin and albumin types. Koya Doras were sampled at five localities to study intra-tribal variation. Tf DChi, a mongoloid genetic marker, was found in high frequencies among Koya Doras (0.029) and Naikpods (0.033) whereas if was absent among Pardhans and showed a very low frequency in Lambadis. A new slow transferrin allele, Tf DGond, is reported from Raj Gonds and is found in polymorphic frequency (0.01). The Hp1 gene frequency ranged from 0.056 to 0.159, and Gc2 ranged from 0.165 to 0.397. No variation was observed with respect to ceruloplasmin. One new albumin variant was found in a single individual of the Koya Dora tribe. The intra-tribal variation in gene frequencies among Koya Doras equalled that found between different tribal populations.
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PMID:Transferrin, haptoglobin and group-specific component types in tribal populations of Andhra Pradesh. 615 77

Vysya population, an endogamous Hindu caste group, was sampled from five distant localities of Andhra Pradesh, S. India and examined for A1A2BO, Rh blood groups, Tf, Hp, Gc, cholinesterase E1 and E2 loci, albumin and ceruloplasmin types. The blood group A has shown an exceptionally low value in these groups and consequently there is a rise in O group frequencies (0.7429 to 0.8144). The incidence of Rh negative individuals is very low (0.1115-0.1571), being absent from one of the groups. Tf DChi is found with a frequency ranging from 0.0043 to 0.0333 with a single fast moving Tf B variant in one of the sub-populations. Hp1 gene frequencies ranged from 0.1271 to 0.2130 and Gc2 from 0.1504 to 0.2773. Silent variants at E1 locus of pseudocholinesterase were present in very high frequencies (0.0115 to 0.1925), the overall frequency being 0.1040. Only a single C+5 was found and dibucaine as well as fluoride resistant variants were rare. No variants were found at the loci of albumin and ceruloplasmin. Differentiation in the distribution of these variants in the five sub-populations of Vysyas reported is evident from these studies.
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PMID:Genetic studies on Vysyas of Andhra Pradesh, S. India: A1A2BO, Rh (O) D, transferrin, group specific component, haptoglobin and pseudocholinesterase types. 679 69

The blood protein polymorphism of serum albumin, haptoglobin, transferrin, ceruloplasmin and haemoglobin have been studied in 135 samples from one-humped Arabian camel (Camelus dromedarius) of the Sudan by starch gel electrophoresis. Only the serum albumin and haptoglobin systems exhibited polymorphism with the estimated frequencies of 0.0222, 0.2227 and 0.7773 for Albv, Hp1 and Hp2 respectively. The frequency of Hp0 was 0.0325. No electrophoretic variant was observed at transferrin, ceruloplasmin and haemoglobin loci in the camel. The activity of the ceruloplasmin of the camel sera was weak.
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PMID:Blood protein polymorphism in the one-humped camel (Camelus dromedarius) in the Sudan. 739 42

The antioxidative potential of haptoglobin is type dependent; Hp2-2 has much lower antioxidative capacity than Hp1-1 or Hp2-1. It is therefore possible that other antioxidants may compensate for decreased antioxidative capacity in Hp2-2 individuals. Haptoglobin polymorphism was correlated with ceruloplasmin ferroxidase activity in a sample population of unrelated black Jordanians. Hp2-1 was the predominant type, occurring at a frequency of 0.518 and Hp2 was the common allele, occurring at a frequency of 0.6455; no Hp0-0 individuals were observed in the sample population. In general, haptoglobin concentration was highest among Hp1 homozygotes and lowest among Hp2 homozygotes, while ceruloplasmin ferroxidase activity was highest among Hp2 homozygotes and lowest among Hp1 homozygotes. Furthermore, ceruloplasmin ferroxidase activity was higher at haptoglobin concentrations >85 mg/dl compared with that at haptoglobin concentrations of 30-85 mg/dl, which was also higher than at haptoglobin concentrations <30 mg/dl, irrespective of haptoglobin type. These results suggest that ceruloplasmin ferroxidase activity is both haptoglobin type and concentration dependent.
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PMID:The relationship between haptoglobin polymorphism and serum ceruloplasmin ferroxidase activity. 1510 12