Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.16.3.1 (
ceruloplasmin
)
5,074
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We investigated the role of
ceruloplasmin
in the antioxidative process in the brain in a patient with hereditary
ceruloplasmin
deficiency (HCD). Immunohistochemistry revealed an accumulation of Nepsilon-(carboxymethyl) lysine (
CML
) in basal ganglia of the HCD brain. In vitro study disclosed that
ceruloplasmin
inhibited
CML
formation from glycated proteins through the reaction of Fe2+ with H2O2 by Fenton reaction. These data suggest that
ceruloplasmin
plays an important role in the protection of neurons against oxidative stress associated with iron metabolism.
...
PMID:Hereditary ceruloplasmin deficiency increases advanced glycation end products in the brain. 1044 2
