Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: EC:1.16.3.1 (ceruloplasmin)
5,074 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An accident in a hemodialysis unit involving 13 patients is reported. Circumstantial evidence suggests that acid contamination of the water supply to the unit resulted in inactivation of heparin with widespread extracorporeal clotting and secondary copper intoxication which proved fatal in one patient. Serum copper concentrations were raised in 6 of the 11 patients and whole blood copper concentrations were raised in 4 patients. Results of serum ceruloplasmin, whole blood lead and zinc analyses are reported together with tissue analyses for copper in the fatal case. The majority of the patients showed evidence of a metabolic acidosis.
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PMID:Heparin inactivation, acidosis and copper poisoning due to presumed acid contamination of water in a hemodialysis unit. 664 Oct 26

Humidifiers are rapidly contaminated with organisms and become a dangerous source of bacterial propagation unless special measures are taken. The growth of these organisms can be completely avoided by introducing metallic copper into the reservoir of humidifiers, as proposed as early as 1970 by Dean. The authors demonstrate experimentally that only nebulizers, in contrast to draw-over humidifiers and "bubblers", yield measurable quantities of copper. In a clinical study urine copper and plasma levels were measured in patients ventilated through a humidifier working on the draw-over principle. The results were compared with another group of patients ventilated with an aerosol of water containing copper. Copper excretion in the urine of this group rose well above the upper limit of normal between the second and fourth day, whereas copper in the urine of the first group (draw-over) remained within the normal range all the time. With a few exceptions the copper level in the plasma of both groups remained within normal limits. Plasma caeruloplasmin determination in both groups revealed no abnormal levels, a fact which appears to indicate that an overdose of copper could virtually be excluded. Nor were there clinical symptoms of copper intoxication.
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PMID:[Copper poisoning caused by humidifiers?]. 726 49

Molybdenum, as ammonium molybdate, was added to the drinking water of 5-wk-old calves to establish the minimum toxic concentration. A basal diet with 13 ppm copper and .29% sulfur was fed ad libitum for 21 days. The concentration of copper in liver was reduced with 50 ppm added molybdenum in water but not with 1 or 10 ppm. However, copper in plasma was elevated with 50 ppm added molybdenum in water while changes in ceruloplasmin concentration were nonsignificant. The calculated percent copper as ceruloplasmin copper in plasma decreased from 61% to 43% with all additions of molybdenum. Apparently uptake of plasma copper by tissues was reduced by molybdenum decreasing the bioavailability of copper. These data indicate the difficulty of detecting molybdenum-induced hypocuprosis from plasma copper and ceruloplasmin without data on tissue copper. With dietary levels of 13 ppm copper and .29% sulfur, the minimum toxic concentration of molybdenum in drinking water for calves is between 10 and 50 ppm, and the critical copper-to-molybdenum ratio is less than .5. Molybdenum in water may be less toxic to calves than molybdenum in fresh forages.
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PMID:Toxicity of ammonium molybdate added to drinking water of calves. 738 Oct 83

Similarities in morphology between copper-deficient cartilage and abnormal cartilage associated with tibial dyschondroplasis (TD) led to studies dealing with copper metabolism and its possible relation to TD. Abnormal cartilage and copper deficient cartilage cells both oxidize significantly less glucose to CO2 and water when compared to normal epiphyseal and day-old hypertrophic cartilage cells. Plasma ceruloplasmin levels and cartilage copper content were not different between normal birds and those affected wth TD, which seemed to rule out a genetic defect in copper metabolism as being partly responsible for the abnormal cartilage occurrence. Mitochondrial marker enzyme activities were investigated, and abnormal cartilage showed a significant decrease in activity of both cytochrome oxidase and citrate synthase. The yield of mitochondria on a percent of total activity basis was quite low from both normal and abnormal cartilages, and, thus, an absolute conclusion with regard to mitochondrial impairment cannot be made at this time.
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PMID:Metabolism of abnormal cartilage cells associated with tibial dyschondroplasia. 741 92

Calcium, magnesium, copper and zinc were determined in serum in men with femoral atherosclerosis. Also total cholesterol, HDL- and LDL-cholesterol were estimated. Subjects in control group were in the same range of age. The present study compares two methods of preparing serum for the flame atomic absorption spectrometry. In the first method (I), serum was diluted by the demineralized water. In the second method (II), serum protein was precipitated by trichloracetic acid (TCA). We found that the first method (I) was simpler and more precise than the other. The optimal proportions of serum and water amounted to 1 + 62 for calcium and magnesium and the coefficient of variation (C.V.) was 2.8%. For copper and zinc, the optimal dilution was 1 + 3 (C.V. = 1%). Total cholesterol was significantly higher (p < 0.05) and HDL-cholesterol was lower (p < 0.05) in subjects with femoral atherosclerosis as compared with controls. There was no difference in LDL-cholesterol. Subjects with femoral atherosclerosis had significantly higher level of all micro- and macroelements determined, then those of the control group (p < 0.05). However, higher serum copper does not necessary mean higher copper body status. It is possible that higher serum copper in femoral atherosclerosis reflects the transfer of copper from the tissue to the ceruloplasmin, as an acute phase reaction. On the other hand, the differences in serum magnesium, calcium, copper and zinc concentrations, may indicate the possible involvement of these elements in the disorder of total and HDL-cholesterol in femoral atherosclerosis.
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PMID:[Calcium, magnesium, copper and zinc in blood serum in men with femoral atherosclerosis]. 748 5

The role of sodium molybdate (1 mg/kg, intraperitoneally, once daily) supplementation during the course of lead exposure (0.1% lead acetate in drinking water for 4 weeks) in preventing the accumulation of lead in blood and soft tissues and in restoring altered lead-sensitive biochemical variables and the levels of hepatic glutathione, lipid peroxidation, blood Na, blood K, and serum ceruloplasmin was investigated in rats. The data indicate that sodium molybdate significantly protected the uptake of lead in blood, liver, and kidneys and restored the lead-induced inhibited activity of blood delta-aminolevulinic acid dehydratase, elevation of blood zinc protoporphyrin, hepatic lipid peroxidation, and serum ceruloplasmin. The results suggest a significant role of sodium molybdate in preventing plumbism.
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PMID:Preventive effects of sodium molybdate in lead intoxication in rats. 750 10

Clinical analysis was carried out of El Tor cholera in 100 patients, plasma concentrations of electrolytes of potassium (K) and sodium (Na) were studied as were those of trace elements of iron (Fe), copper (Cu), magnesium (Mg) and manganese (Mn) in the whole blood before and after rehydration therapy and depending on the extent of dehydration. The results were as follows: the plasma concentration of K and Na was lowered, that of Mg in the whole blood increased in stage III as well as that of Mn in st. I and II of dehydration; the concentration of Fe, Cu was decreased in st. I, II, III, and of Mn in sit. III of dehydration. The activities of transferrin and ceruloplasmin were found to be on the decrease for the duration of the illness. Rehydration promoted the return to normal of water and electrolyte metabolism, haemodynamics, without affecting to any noticeable degree the trace element metabolism.
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PMID:[Disordered water-mineral metabolism in cholera patients]. 783 90

Three experiments were conducted to determine the influence of triiodothyronine (T3) or propylthiouracil (PTU) on the humoral immune response of calves challenged with infectious bovine rhinotracheitis virus (IBRV) and on nitrogen depletion and repletion of lambs deprived of feed and water for 3 d. In Exp. 1, 18 steer calves (BW 284 +/- 6 kg) challenged with IBRV were limit-fed (1.5% BW) a 60% concentrate diet and injected (s.c.) daily with alkaline saline, .4 mg of T3, or .8 mg of T3. Injections of T3 did not affect serum antibody titers to IBRV, blood leukocyte counts, or plasma free fatty acid, ceruloplasmin, and cholesterol concentrations but increased (P < .05) plasma glucose concentrations and decreased (P < .05) plasma urea N concentrations. In Exp. 2, 36 IBRV-challenged steers (BW 266 +/- 8 kg) were given ad libitum access to a 60% concentrate diet and injected (s.c.) daily with alkaline saline, .2 mg of T3, or .4 mg of T3. In contrast to Exp. 1, injections of T3 did not affect plasma glucose or urea N concentrations and reduced (P < .05) serum antibody titers to IBRV. In Exp. 3, eight wether lambs were limit-fed (600 g/d) a 36% concentrate pelleted diet and assigned to one of four treatments in a replicated 4 x 4 Latin square designed nutrient balance experiment involving periods of nutrient depletion and repletion. Treatments were as follows: 1) alkaline saline injection (s.c.), 2) 4 mg of PTU/kg BW in water, 3) .15 mg of T3 s.c. daily for 15 d, and 4) .15 mg of T3 s.c. daily for 7 d after the 3-d feed and water deprivation period. Thyroid status affected (P < .05) predeprivation N balance but did not affect N losses during the feed and water deprivation period. Retention of N during realimentation was affected (P < .05) by T3 treatment. Results of these experiments indicate that there is a complex interrelationship among stress, nutrient status, and thyroidal status and that the effects of T3 injections on immune and metabolic responses may be dependent on the nutritional status of the animal.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Influence of triiodothyronine injections on calf immune response to an infectious bovine rhinotracheitis virus challenge and nitrogen balance of lambs. 805 73

Female rats are protected from the lethal effects of a dietary copper (Cu) deficiency, but female mice fed a Cu-deficient diet develop atrial thromboses and die. To further investigate the effect of sex on Cu status in mice (n = 16), male and female adult Swiss-Webster mice were fed Cu-supplemented (8.4 mg Cu/kg) or Cu-deficient (0.3 mg Cu/kg) diets with deionized water for 43-49 days. Six female mice, but only one male mouse, fed the Cu-deficient diet died during the experiment. Both male and female mice fed the Cu-deficient diet exhibited typical features of deficiency. The severity of anemia and the values observed for several indicators of Cu status (plasma ceruloplasmin [EC 1.16.3.1.] and erythrocyte copper-zinc superoxide dismutase [EC 1.15.1.1.] activities, cardiac Cu) were similar in both male and female Cu-deficient mice. However, cardiac enlargement (0.97 vs 0.73 g/100 g body wt, P < 0.05), cardiac edema (79.9% vs 78.2% cardiac water, P < 0.05) and depletion of renal Cu (10.4 vs 12.5 micrograms/g dry weight, P < 0.05) were more severe in female compared with male, Cu-deficient mice. Furthermore, although hepatic Cu was significantly (P < 0.05) lower in female Cu-deficient compared with Cu-supplemented mice, it was not significantly decreased by deficiency in male mice. These data indicate that the female mice experienced a more extreme form of Cu deficiency than the males.
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PMID:Contrasting effects of a dietary copper deficiency in male and female mice. 810 71

The effect of sodium metavanadate (NaVO3) consumption on trace element metabolism, components of the antioxidant defense system and lipid oxidative damage were studied in control (CON) and streptozotocin-induced diabetic (DIAB) rats. Ten days after injection, CON and DIAB rats received either 0 mM NaVO3/80 mM NaCl (0 group) or 1.2 mM NaVO3/80 mM NaCl (1.2V group) in their drinking water. DIAB groups had higher food and fluid intakes than the CON groups; vanadium (V) groups had lower food and fluid intakes than the saline groups. Vanadium therapy lowered plasma glucose concentrations of DIAB rats. The following parameters were similar among the groups: plasma Zn, Cu and Fe concentrations, plasma ceruloplasmin activity, liver Zn, Cu, Mn and Fe concentrations, kidney Mn and Fe concentrations, liver non-Se-dependent glutathione peroxidase (GSH-Px), glutathione reductase (GSH-Red) and Mn-SOD activities, liver reduced glutathione (GSH) and oxidized glutathione (GSSG) concentrations and kidney non-Se-dependent GSH-Px activity. Kidney Zn and Cu concentrations were higher in DIAB rats than in CON rats. The CON-1.2V and DIAB-1.2V groups had V accumulation in the liver and kidney. Liver CuZn-SOD and Se-dependent GSH-Px and kidney CuZn-SOD and GSH-Red activities were lower in DIAB rats compared to CON rats; kidney Mn-SOD and kidney Se-dependent GSH-Px activities were higher in DIAB rats than CON rats. Vanadium treatment did not cause significant alterations in the antioxidant defense system; however, tissue vanadium concentrations were positively correlated to TBARS production. These results show that diabetes caused significant alterations in the antioxidant defense system and that V therapy was associated with a marked deterioration in health of both control and diabetic rats.
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PMID:Vanadium treatment of diabetic Sprague-Dawley rats results in tissue vanadium accumulation and pro-oxidant effects. 824 40


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