Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: EC:1.16.3.1 (ceruloplasmin)
5,074 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Three recombinant human apoferritin variants were added to ferrous iron and the amount of lipid peroxidation produced by hydrogen peroxide was studied. The H-apoferritin had the strongest inhibitory effect on lipid peroxidation, probably due to its ferroxidase activity. The L-apoferritin inhibited lipid peroxidation slowly and only at neutral pH. The H-mutant 91, deleted of the last 22 C-terminal amino acids, and which is not able to form an iron core, had minimal effects on iron lipid peroxidation. It was concluded that both ferro-oxidase and iron mineralization activities are necessary for ferritin iron detoxifying action.
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PMID:Iron detoxifying activity of ferritin. Effects of H and L human apoferritins on lipid peroxidation in vitro. 226 41

The concentrations of three trace elements (iron, copper and zinc) involved in hematopoiesis were studied in 200 patients with iron-deficit anemia, hemolytic anemia and Biermer's anemia, in comparison with a group of normal subjects. The method used was atomic absorption spectrophotometry. The results obtained showed that in iron-deficit anemia resistant to iron therapy the copper and ceruloplasmin serum concentrations are at the lowest limit of normal. This copper deficit has a negative effect on the disease by preventing hemoglobin synthesis. In iron-deficit anemias responding to iron therapy the relatively low (about 90 gamma %) zinc values have a negative effect by blocking the iron in the iron reserve. In hemolytic anemia the very high zinc serum concentrations (over 200 gamma %) may lead to a shortening of the erythrocytes life span due to its "entatic state". In Biermer's anemia zinc by its high concentration has a positive role owing to carbonic anhydrase which eliminates more rapidly carbon dioxide from the organism.
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PMID:Possible correlation between the zinc and copper concentrations involved in the pathogenesis of various forms of anemia. 228 64

Pea seed ferritin is able to incorporate ferrous iron into the mineral core. Fe2+ may be formed by reduction of exogenous Fe3+ with ascorbate or by photoreduction by ferritin and by ferric citrate. In our experimental conditions the bulk of the photoreduction is carried out by ferritin, which is able to photoreduce its endogenous iron. Citrate does not enhance the photoreduction capacity of ferritin, and exogenous ferric citrate improves the yield of the reaction by about 30%. The mineral core of the ferritin is shown to photoreduce actively, and the protein shell does not participate directly in the photoreduction. Low light intensities and low concentration of reducing agents do not allow a release of iron from ferritins, but induce a 'redox mill' of photoreduction and simultaneous ferroxidase-mediated incorporation. High ascorbate concentrations induce the release of ferritin iron. These reactions are accompanied by the correlated occurrence of damage caused by radicals arising from Fenton reactions, leading to specific cleavages in the 28 kDa phytoferritin subunit. This damage caused by radicals occurs during the oxidative incorporation into the mineral core and is prevented by o-phenanthroline or by keeping the samples in the dark.
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PMID:Photoreduction and incorporation of iron into ferritins. 237 59

Basing on the literature data and their own findings, the authors present the general biological concept of osteogenesis. The significance of copper compounds (ceruloplasmin) in bone tissue synthesis was revealed; the role of bound iron (transferrin) in the development and maintenance of the inflammatory process induced by opportunistic bacteria and in bone regeneration was confirmed. Analysis of clinical and microbiological findings in the patients with chronic posttraumatic osteomyelitis, coral uroliths, gastrointestinal diseases complicated by cholelithiasis has lead the authors to a suggestion that fecal microcenosis may become one of the criteria for estimating mineral metabolism in the body; the markers of this metabolic disorders are shifted levels of full-value E. coli, Lactobacilli, and, to a lesser degree, of L. bifidum. The presence of E. coli hemolytic variant also essentially contributes to these disorders, when its level surpasses by 2-3 orders the level of this microorganism in normal subjects and in patients whose mineral metabolism is virtually unchanged. When planning multiple-modality treatment of patients with locomotor system defects and disordered salt metabolism, a physician should investigate intestinal biocenosis and prescribe agents to correct the detected disorders.
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PMID:[Several aspects of general biological concept of osteogenesis]. 239 17

The effects of dietary tin on copper status and on enzymes and metabolites involved in hepatocellular antioxidant protection were measured in rats fed copper-adequate or copper-deficient diets with glucose or fructose. Rats became copper-depleted after 4 weeks on diets containing less than 0.5 micrograms of copper/g as evidenced by significant decreases in liver copper and serum ceruloplasmin. Signs of copper deficiency occurred in copper-depleted rats fed diets containing 100 micrograms of tin/g. Significant effects of tin on liver glutathione peroxidase and superoxide dismutase activities and on liver iron and total glutathione concentrations were observed. Interactions between copper and tin on liver copper and iron and on liver superoxide dismutase and malondialdehyde production are reported. Adverse effects of feeding diets containing 100 micrograms of tin/g include (i) copper depletion in rats fed copper-adequate diets, (ii) accelerated development of copper deficiency in rats fed copper-deficient diets, and (iii) reduction in hepatocellular antioxidant protection.
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PMID:Effects of dietary tin and copper on rat hepatocellular antioxidant protection. 239 53

(1) Attempts to determine the redox-state of the absorbed iron, which appeared in the portal blood when the free iron-binding capacity was previously saturated, indicate that about 30-90% of this iron was in the ferrous state. This effect was particularly prominent after luminal administration of ferrous iron, but was also seen when iron was given in the ferric state. (2) Total iron absorption is significantly higher in ceruloplasmin-substituted copper-deficient animals as compared to copper-deficient controls. (3) The appearance rate of absorbed iron in the portal blood of copper-deficient animals increased several times immediately after the intravenous infusion of ceruloplasmin. (5) The distribution of absorbed iron was changed due to the ceruloplasmin substitution: it was increased in the reticulocytes (+66%), plasma (+400%) and the body (+112%), whereas in the liver it was decreased by about 78%. (5) In iron-deficient rats intravenously injected ceruloplasmin did not increase iron absorption. (6) The conclusion was drawn that, as for the entrance into the mucosa from the luminal side, also for the release at the contraluminal side into the portal blood, the ferrous state of iron is favoured and that ceruloplasmin accelerates the release into the portal blood by catalyzing the oxidation of ferrous iron due to its high Fe(II): oxygen oxidoreductase (EC 1.16.3.1) activity.
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PMID:The valency state of absorbed iron appearing in the portal blood and ceruloplasmin substitution. 240 Jun 27

Twenty-two children with Down syndrome (DS), 8 boys and 14 girls, in the age range 5 to 15 years were investigated and compared with a control group of 22 healthy children, 9 boys and 13 girls of the same age group, 9 of them being siblings of patients with DS. Concentrations of iron, copper and zinc in serum were determined by atomic absorption spectrophotometry and serum proteins were quantitated by the radial immunodiffusion technique. The subjects with DS had significantly lower mean serum iron (P less than 0.01) and zinc (P less than 0.001) than the healthy controls. Four DS children had serum iron values that fell below the normal range. In more than 60 per cent of the DS patients the zinc concentration fell below the normal range. The children with DS had significantly higher mean serum copper (P less than 0.05) but lower serum iron (P less than 0.05) and zinc (P less than 0.05) levels than their healthy siblings living in the same family at the time of examination. The DS patients as a group had higher levels of caeruloplasmin (P less than 0.01), haptoglobin (P less than 0.001), orosomucoid (P less than 0.001) and alpha 2-macroglobulin (P less than 0.001) than the healthy controls and compared with their siblings. Except for prealbumin and retinol-binding protein (RBP), no age-related variation in the serum concentrations of the studied proteins was found in the DS patients. Albumin, prealbumin, RBP and transferrin levels were similar in the two study groups.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Trace elements and transport proteins in serum of children with Down syndrome and of healthy siblings living in the same environment. 244 24

Some 40% of knee-joint synovial fluids from arthritic patients show the presence of bleomycin-detectable iron. This is released from a protein component of the fluid to bleomycin at acidic pH values. Patients whose fluids release iron have lower contents of transferrin, lactoferrin and caeruloplasmin than do patients whose fluids do not release iron to bleomycin. These proteins are important extracellular antioxidants, and measured antioxidant activities are extremely low in the iron-releasing fluids. The propensity of some fluids to release iron at low pH values, characteristic of the microenvironment beneath adherent macrophages, coupled with their decreased antioxidant protection against iron-stimulated oxygen-radical damage, might explain previously reported correlations between clinical disease severity, lipid peroxide content and the presence of bleomycin-detectable iron [Rowley, Gutteridge, Blake, Farr & Halliwell (1984) Clin. Sci. 66, 691-695].
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PMID:Bleomycin-detectable iron in knee-joint synovial fluid from arthritic patients and its relationship to the extracellular antioxidant activities of caeruloplasmin, transferrin and lactoferrin. 244 16

The blood serum ceruloplasmin, transferrin, malonic dialdehyde, iron and copper levels have been measured in donors. These parameters varied in groups of subjects aged 20-29 and 30-45, no age-associated differences being recorded within both the groups. Certain differences have been revealed between the donors who furnished their blood more or less than 3 times a year. The results of this investigation may be useful in clinical screenings of donors.
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PMID:[Indices of lipid peroxidation and the ceruloplasmin-transferrin antioxidant system in donors]. 246 15

Methods are described for the quantification of certain acute phase reactants (albumin, iron, fibrinogen, seromucoid, haptoglobin, and ceruloplasmin) in small amounts of plasma using the COBAS-BIO centrifugal analyzer. These methods have been applied to determine the concentrations of these acute-phase reactants (APRs) in rat plasma during the first 5 days of adjuvant-induced arthritis. The levels of the APRs alter with the degree of inflammation in a dose-related manner. Administration of the antiinflammatory and antirheumatic drugs (indomethacin, dexamethasone, and clobuzarit [CLOZIC]) during the course of the adjuvant-induced arthritis reduced the inflammatory response as judged by the measurement of oedema. These compounds, however, show differential effects on the profile of APRs as systemic measurements of the inflammatory disease. The present study shows that specific classes of drug have defined effects on acute-phase protein concentration. We believe that the multiple analysis of APR levels during the course of inflammation may help to distinguish between and elucidate the mechanisms of action, of antiinflammatory and antirheumatic drugs.
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PMID:Automated quantification of rat plasma acute phase reactants in experimental inflammation. 247 Oct 18


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