Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:1.16.3.1 (ceruloplasmin)
 5,074 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A study is presented of the effect of a new native calcium antagonist foridon on the course of the disease central and peripheral hemodynamics, fatty metabolism, lipid peroxidation intensity, activity of ceruloplasmin and catalase, iron and chromium saturation of transferrin, content of cyclic nucleotides in thrombocytes, the state of cellular immunity and the number of circulating immune complex in 30 patients with advancing and stable exertion stenocardia (control--30 analogous patients treated by phynoptin and corinfar). It was established that foridon produced a positive effect on the intensity of the pain syndrome, hemodynamics, degree of lipid peroxidation, content of cyclic nucleotides and immune status of stenocardia patients.
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PMID:[The efficacy of foridon in treating stenocardia patients]. 180 58

The acute effects of prolonged exercise on the body's distribution of trace minerals in women athletes has not been examined. To this end, plasma concentrations of zinc, copper, and iron; erythrocyte zinc (EZn) and copper (ECu); and the associated proteins, ceruloplasmin and transferrin were measured in 38 highly trained women runners under resting conditions and again after running a competitive 26.2 mile marathon. The hormones, cortisol (C), estradiol (E2), prolactin (Prl), follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were also measured because of reported effects of hormones on trace mineral distribution. Menstrual status was assessed by questionnaire: 8 women were in the follicular phase, 13 in mid-cycle, 8 in the luteal phase and 9 were amenorrheic (AM). Significant post-race increases were noted for all plasma minerals, associated proteins, and the hormones C and Prl, whereas EZn decreased. No significant changes in ECu, E2, FSH or LH were noted. Menstrual status in terms of cycle phase or amenorrhea did not appear to modify the response. Exercise-induced changes in minerals may reflect release from other tissues and/or changes in the concentration of associated proteins. Whether these changes serve adaptive and/or specific functions during exercise is unknown.
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PMID:Exercise-induced changes in blood minerals, associated proteins and hormones in women athletes. 180 33

Concentration of trace levels of copper, iron and selenium as well as activity of superoxide dismutase and content of ceruloplasmin and transferrin were studied in blood serum of 70 patients with defects and deformations of cervicofacial region before and after surgical plastic operations approximately similar in their size and the rate of traumatic injury. Alterations in content of the trace elements as well as in content and activity of the metalloenzymes, observed during pyo-inflammatory complications, were considerably distinct from these patterns detected in noncomplicated wound inflammation; the patterns studied may be used for prognostic purposes.
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PMID:[Microelements and their blood protein level in patients in the prognosis of purulent-inflammatory complications after cervicofacial operations]. 181 25

Normal human plasma does not contain low molecular mass iron because the iron-binding protein transferrin retains a considerable iron-binding capacity. In conditions of iron-overload, however, low molecular mass iron can be detected in plasma. Plasma contains several molecules capable of reducing ferric complexes to the ferrous state and this could lead to oxidative damage through reactions dependent on Fenton chemistry and lipid peroxidation. It seems likely that ascorbate and urate would reduce ferric complexes present in plasma during iron-overload. However, the plasma, 'ferroxidase' protein caeruloplasmin protects the extracellular environment by catalytically oxidising ferrous complexes back to the less reactive ferric state.
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PMID:Reduction of low molecular mass iron by reducing molecules present in plasma and the protective action of caeruloplasmin. 182 39

The combination of liquid chromatography and inductively coupled plasma/mass spectrometry (ICP/MS) was employed in an exploratory study to determine lead and other trace element species in blood components. In human blood serum, lead was found in at least three molecular weight fractions at greater than 600,000, 260,000, and 140,000. The major part of lead was coincident with the main copper signal at a molecular weight of 140,000. This fraction, binding both copper and lead, was proven to be ceruloplasmin by the application of an immunological reaction prior to chromatographic separation. In rat serum, lead could be detected in four fractions with molecular weights of greater than 600,000, 400,000, 145,000, and 11,000. In human red blood cell hemolysate, the major fraction of lead was found at 250,000, with minor fractions at 140,000 and at 30,000 together with iron in hemoglobin and zinc in carbonic anhydrase. In rat red blood cell hemolysate, lead was detected at greater than 600,000, 145,000, 30,000, and 11,000. Lead isotope ratios were determined in lead binding protein fractions with a precision of +/- 10%. The detection limit for lead in protein fractions was 0.15 micrograms.L-1.
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PMID:Determination of lead and other trace element species in blood by size exclusion chromatography and inductively coupled plasma/mass spectrometry. 182 13

The structure and crystal chemical properties of iron cores of reconstituted recombinant human ferritins and their site-directed variants have been studied by transmission electron microscopy and electron diffraction. The kinetics of Fe uptake have been compared spectrophotometrically. Recombinant L and H-chain ferritins, and recombinant H-chain variants incorporating modifications in the threefold (Asp131----His or Glu134----Ala) and fourfold (Leu169----Arg) channels, at the partially buried ferroxidase sites (Glu62,His65----Lys,Gly), a putative nucleation site on the inner surface (Glu61,Glu64,Glu67----Ala), and both the ferroxidase and nucleation sites (Glu62,His65----Lys,Gly and Glu61,Glu64,Glu67----Ala), were investigated. An additional H-chain variant, incorporating substitution of the last ten C-terminal residues for those of the L-chain protein, was also studied. Most of the proteins assimilated iron to give discrete electron-dense cores of the Fe(III) hydrated oxide, ferrihydrite (Fe2O3.nH2O). No differences were observed for variants modified in the three- or fourfold channels compared with the unmodified H-chain ferritin. The recombinant L-chain ferritin and H-chain variant depleted of the ferroxidase site, however, showed markedly reduced uptake kinetics and comprised cores of increased diameter and regularity. Depletion of the inner surface Glu residues, whilst maintaining the ferroxidase site, resulted in a partially reduced rate of Fe uptake and iron cores of wider particle size distribution. Modification of both ferroxidase and inner surface Glu residues resulted in complete inhibition of iron uptake and deposition. No cores were observed by electron microscopy although negative staining showed that the protein shell was intact. The general requirement of an appropriate spatial charge density across the cavity surface rather than specific amino acid residues could explain how, in spite of an almost complete lack of identity between the amino acid sequences of bacterioferritin and mammalian ferritins, ferrihydrite is deposited within the cavity of both proteins under similar reconstitution conditions.
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PMID:Influence of site-directed modifications on the formation of iron cores in ferritin. 194 61

The incorporation of tritiated thymidine into CCL-39 cells grown in the absence of fetal calf serum or other growth factors is greatly increased by low concentrations of ceruloplasmin. The stimulation is greater than observed with serum or thrombin. Addition of serum decreases the thymidine incorporation with ceruloplasmin to the level with serum alone. As with serum, the response to ceruloplasmin is high at both 20% and 1% oxygen, which is consistent with the action of ceruloplasmin as an oxidant with a high affinity for oxygen. Since transplasma membrane electron transport increases cell growth and thymidine incorporation, ceruloplasmin may act as a terminal oxidase for ferrous iron or ascorbate to stimulate transplasma membrane electron transport. The four electron transfer from ceruloplasmin to oxygen to form water will prevent peroxide formation at the cell surface. Alternatively, superoxide formation inside the cell or membrane could employ the superoxide dismutase function of ceruloplasmin to produce peroxide. Either mechanism would be consistent with the previously described stimulation of growth by external oxidants.
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PMID:Ceruloplasmin stimulates thymidine incorporation by CCL-39 cells in the absence of serum or growth factors. 195 52

Iron-storage proteins can be divided into two classes; the bacterioferritins and ferritins. In spite of many apparent structural and functional analogies, no significant amino acid sequence similarity has been detected previously. This report now reveals a distant evolutionary relationship between bacterioferritins and ferritins derived by 'Profile Analysis'. Optimum alignment of bacterioferritin and ferritin sequences suggests that key residues of the ferroxidase centres of ferritins are conserved in bacterioferritins.
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PMID:Bacterioferritins and ferritins are distantly related in evolution. Conservation of ferroxidase-centre residues. 195 54

The efficacy of a drug containing three heavy metals together has been tested in adjuvant-induced arthritic rats. Treated rats were injected with 22.8 micrograms copper gluconate, 0.2 microgram gold thioglucose and 6.8 micrograms silver proteinate each day during a period of 29 days. The drug treatment was found to diminish the increases in plasma levels of haptoglobin, ceruloplasmin, PGE2, 6-keto-PGF1 alpha and copper, the decrease in the iron plasma level induced by Freund's adjuvant and the paw swelling. No effect was seen on the plasma levels of TXB2, Zn, Se, Mn and Ni. Therefore the simultaneous administration of low doses of gold, copper and silver had a real anti-rheumatic property in this model. These results should be of interest for the long-term treatment of arthritis.
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PMID:Anti-inflammatory properties of a preparation containing low doses of copper, gold and silver. 198 Sep 12

Plasma zinc, iron, copper, and selenium and selected blood proteins were measured in 66 men before (BHW) and after (AHW) a 5-d period of sustained physical and psychological stress called Hell Week. Recovery blood samples were obtained from 26 men 7 d after Hell Week. Dietary intakes were determined BHW and during Hell Week; zinc, iron, copper, and selenium intakes during Hell Week averaged 23.6 +/- 3.4 mg/d, 35.4 +/- 3.9 mg/d, 3.0 +/- 0.5 mg/d, and 92.5 +/- 26.7 micrograms/d, respectively. C-reactive protein was detected in only five subjects BHW and in all subjects AHW. Zinc, iron, selenium, and albumin decreased by 33%, 44%, 12%, and 9%, respectively, whereas ferritin, ceruloplasmin, and creatine kinase concentrations increased AHW by 59%, 8%, and 266%, respectively. Haptoglobin concentrations increased 57% in 30 subjects but decreased 32% in 23 subjects AHW. The biochemical changes were transitory because protein (except ferritin) and mineral concentrations were similar to BHW values 7 d after Hell Week. Hell Week induced changes characteristic of an acute-phase response in physically active men.
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PMID:Biochemical indices of selected trace minerals in men: effect of stress. 198 37


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