Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:1.16.3.1 (ceruloplasmin)
 5,074 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effects of dietary addition of some xenobiotics on tissue levels of copper and alpha-tocopherol in rats were studied with special reference to serum cholesterol. The chemicals added here were 0.05% polychlorinated biphenyls (PCB), 0.3% caffeine, 0.05% 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT), 0.3% flavone, 0.3% chloretone, 0.3% 2-tert-butyl-4-methoxyphenol (BHA), 0.15% sodium phenobarbital, 0.15% phenytoin, 0.2% sodium pentobarbital, and 0.15% phenylbutazone. Of these chemicals, dietary PCB, caffeine, DDT, flavone, chloretone, BHA and phenytoin raised the level of copper in liver, kidney, or serum. Serum alpha-tocopherol and cholesterol also increased with the additive or synergistic effects on these metabolisms. Moreover, these combined addition of dietary 0.02% PCB with 0.2% BHA seemed to cause additive or synergistic effects on these metabolism. Moreover, these chemicals raised serum ceruloplasmin activity. In general, serum copper, ceruloplasmin activity and alpha-tocopherol were correlated with serum cholesterol in these dietary manipulations.
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PMID:Effects of dietary xenobiotics on the metabolism of copper, alpha-tocopherol and cholesterol in rats. 312 11

The aim of the paper was to compare the erythrocyte serum and hepatic chomogenate antioxidative factors in order to assess their involvement in the detoxification events. The catalase and superoxiddismutase levels, important factors of the cellular defence, were sensitivity modulated in an acute experiment on Wistar rats. Carbofuran was administered in a non-lethal dose (7 mg/b.w.) single or in the presence of certain antioxidative agents (Vitamin E, Caffeine, Aspirin) EDTA and Cysteine for their role in protecting membranes against oxidative damage. The erythrocyte parameters (SOD, Catalase) were well related to seric factors, especially ceruloplasmin level, with varied magnitudes. GGT a marker of hepatotoxicity and G1-DH, a mitochondrial marker, were in a good correlation with erythrocyte factors. The changes seem to modulate a transmembranary disturbance process, as in hepatocyte pictures.
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PMID:Interference of some enzymatic modulators in the hepatic aggression induced by xenobiotics. 754 89