Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.16.3.1 (ceruloplasmin)
 5,074 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Male rats were given oestradiol benzoate (1 mg as an aquaeous microcrystal suspension i.m. twice a week), testosterone isobutyrate (0.5 mg as an aquaeous microcrystal suspension i.m. once a week) and dried thyroid (Thyreoidin SPOFA, 0.2% in food), alone or variously combined. Oestradiol raised adenohypophyseal weight, the binding capacity of the adenohypophyseal proteins for thyroxine and the serum ceruloplasmin level. Testosterone and Thyreoidin inhibited all three of these reactions, but when they were administered together there was no summation of their inhibitory action. The nature of the relationships between the three given proteosynthetic reactions is discussed.
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PMID:Effect of interaction of oestrogen, testosterone and thyroid hormones on the serum ceruloplasmin level in rats. 14 Mar 85

The interaction of perphenazine and an ergoline derivative on estrogen-induced adenohypophyseal growth was studied in rats. Animals received perphenazine (Per; 2 mg) the ergoline derivative D-6-methyl-8-ergoline-(I)-yl acetic acid amide (200 mcg/rat/day), estradiol benzoate (EB; 1 mg) alone or in combination with 1 or more. Animals were killed after 3 weeks of treatment and adenohypophyses, thyroids, adrenals, testes, and seminal vesicles or ovaries and uteri were removed. Serum ceruloplasmin level and thyroxine binding to the adenohypophyseal proteins were determined. Estradiol induced marked growth of the adenohypophysis which was slightly potentiated by Per in males but significantly inhibited by the ergoline derivative in both sexes. When Per was given with the ergoline derivative the inhibitory effect was blocked. The ergoline derivative also inhibited the EB-induced increase in thyroxine-binding capacity of the adenohypophyseal proteins. However, in this instance, Per was ineffective in blocking this inhibition. Ceruloplasmin level which increased following EB administration was unaffected by administration of either Per or the ergoline derivative. In males, adrenal weight rose slightly after Per and markedly after EB. Testicular weight fell in all groups given EB and unaffected by the test drugs. Ovarian weight rose after administration of the ergoline derivative but the simultaneous administration of EB or Per prevented the increase.
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PMID:Interaction of perphenazine and an ergoline derivative on oestrogen-induced adenohypophyseal growth. 14 Mar 98