Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.16.3.1 (
ceruloplasmin
)
5,074
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The copper-containing protein
caeruloplasmin
is an important biological extracellular protein. By catalysing the oxidation of ferrous ions to the ferric state (
ferroxidase
activity) it can inhibit lipid peroxidation and the Fenton reaction. This activity is readily destroyed by heat-denaturation. When a ferric-EDTA complex is added to hydrogen peroxide, OH X radicals are formed in a reaction inhibitable by superoxide dismutase (SOD). This reaction is also inhibited by
caeruloplasmin
both before and after heat-denaturation, suggesting a
non-catalytic
scavenging role for the protein. A combination of
ferroxidase
and radical scavenging activities in fluids containing iron complexes and hydrogen peroxide, but no SOD or catalase, would make
caeruloplasmin
an important extracellular antioxidant.
...
PMID:Inhibition of the Fenton reaction by the protein caeruloplasmin and other copper complexes. Assessment of ferroxidase and radical scavenging activities. 300 Jun 33
