Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.16.3.1 (
ceruloplasmin
)
5,074
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Oligo/poly alpha2,8 deaminoneuraminic acid (
KDN
), a unique posttranslational protein modification, was found on megalin and a not yet characterized 150 kDa glycoprotein. We purified this glycoprotein from rat testis and identified it as
ceruloplasmin
. Furthermore, immunoprecipitated
ceruloplasmin
from rat thymus, ovary, blood serum, and postnatal day 2 but not adult lung and brain was immunoreactive for oligo/poly alpha2,8
KDN
. The immunoreactivity for oligo/poly alpha2,8
KDN
on purified serum
ceruloplasmin
was abolished by N-glycosidase F treatment but not by beta-elimination, indicating that it is present on N-glycosidically linked oligosaccharides. However, the copper binding activity of
ceruloplasmin
was independent of the presence of the anionic glycan. By immunohistochemistry,
ceruloplasmin
was detectable in histologically defined regions in rat ovary, thymus, and spleen. Likewise, by RT-PCR,
ceruloplasmin
expression was found in various non-hepatic rat tissues and showed a developmentally regulated pattern. Thus,
ceruloplasmin
, in addition to megalin, represents a glycoprotein carrying oligo/poly alpha2,8
KDN
.
...
PMID:Ceruloplasmin carries the anionic glycan oligo/poly alpha2,8 deaminoneuraminic acid. 1209 80
