Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:1.16.3.1 (ceruloplasmin)
 5,074 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The relationship between biochemical changes in bronchoalveolar lavage fluid (BALF), serum and the lung of different dustexposed rats was studied. Wistar rats were divided into 5 groups: 1. Xingkong chrysotile asbestos (CH-As); 2. Dust in a sieve selection workshop of Xingkong asbestos mine (Dust-Wo); 3. Silica group (SiO2); 4. Titanium dioxide (TiO2) and 5. Normal control group (Control). All the rats were killed in three months after experiment. The results showed that the level of alveolar macrophages (AM), lactic dehydrogenase (LDH) and acid phosphatase (AcP) in each group was marked by related to collagen, lung fat, ceruloplasmin (Cp) and hydroxyproline (HoP) by r and t-test. Among the LDH from BALF, culture fluid and serum, there was also a marked relationship. So the authors pointed out that the BALF especially AM and LDH test could serve as a good and valuable index for detection the condition of pneumoconiosis.
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PMID:[The relationship of biochemical changes among bronchoalveolar lavage fluid serum and lung on dust-exposed rats]. 166 Aug 48

The changes of cellular hydroxyl proline (Hyp) and some other parameters in bronchoalveolar lavage (BAL) induced by different doses of quartz dust (5, 10, 20, or 40mg/per rat) were studied. Quartz dust was administered intratracheally and the rats were killed two weeks after quartz administration. The results showed that the differential count of polymorphonuclear leukocytes (PMN) in BAL, the concentrations of Hyp and total lipids in BAL cells, and the levels of total lipids, total protein, lactic dehydrogenase (LDH) and ceruloplasmin in BAL supernatant all changed significantly in quartz treated groups compared with the control group. Further investigation revealed that the cellular Hyp correlated best with total lung collagen (r = 0.834). This indicated that Hyp might be a specific and important parameter reflecting early increase of total lung collagen after quartz dust administration.
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PMID:[Changes of cellular hydroxyl proline and some other parameters of rats in early bronchoalveolar lavage treated with quartz dust]. 792 54