Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:1.16.3.1 (ceruloplasmin)
 5,074 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two experiments were conducted to compare the effects of a progesterone-estradiol implant (PEI) with no implant (NI) and 20 g of copper oxide needles (CuON) with no CuON on grazing, subsequent feedlot performance, and selected serum constituents of steers. In Exp. 1, 114 Limousin crossbred yearling steers (317 kg average initial BW) were stocked continuously on Acremonium coenophialum-infected tall fescue (Festuca arundinacea Schreb.)-ladino clover (Trifolium repens L.) pastures (C) or were rotated to bermuda grass (Cynodon dactylon [L.] Pers.) during summer months (R) of two consecutive years. Implant and copper treatments were applied within pasture. Blood samples were collected four times during each grazing season. Continuously stocked steers had greater (P less than .05) grazing gain, less (P less than .10) feedlot gain, and heavier (P less than .05) carcass weights than R steers did. Implanted steers had greater (P less than .05) pasture but lesser (P less than .05) feedlot gains than did NI steers. Prolactin concentrations were greater (P less than .05) from R than from C steers in late summer 1988. Ceruloplasmin was greater (P less than .01) with CuON than without on the last three and last two sampling dates in 1988 and 1989, respectively. In Exp. 2, blood samples were collected twice from 40 mixed-breed steers (283 kg average initial BW) receiving the same implant and copper treatments as in Exp. 1 and grazing infected fescue for one season. Serum ceruloplasmin and copper concentrations were increased (P less than .01) by CuON, but other measurements did not differ among treatments. Summer grazing of bermuda grass increased serum copper, ceruloplasmin, and prolactin but decreased grazing performance. Implanting increased grazing performance. Copper oxide needles increased serum ceruloplasmin and copper concentrations but did not affect steer performance.
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PMID:Implant and copper oxide needles for steers grazing Acremonium coenophialum-infected tall fescue pastures: effects on grazing and subsequent feedlot performance and serum constituents. 142 96

Plasma Cu concentrations and ceruloplasmin (a Cu metalloenzyme) activity were used to assess relative Cu bioavailability from different Cu sources for growing cattle. In Exp. 1, 18 calves (average BW 207 +/- 7.7 kg) that had been fed Cu-deficient diets since birth were randomly assigned to treatment. Treatments consisted of control (n = 3) or 30 mg/d of supplemental Cu (n = 5/treatment) from Cu oxide (CuO), Cu sulfate (CuSO4), or Cu lysine. Blood samples were obtained for plasma Cu and ceruloplasmin activity on d 0, 7, 14, and 21. Plasma Cu and ceruloplasmin activity were greater (P < .05) on d 7, 14, and 21 for calves supplemented with CuSO4 than for controls. Copper status of calves fed Cu lysine did not differ from that of calves fed CuSO4. Compared with d-0 values, plasma Cu concentrations by d 21 had increased by 95 and 98% in calves supplemented with CuSO4 and Cu lysine, respectively. Copper oxide supplementation did not increase Cu status above that observed in control calves. In Exp. 2, 36 calves (average BW 211 +/- 4.4 kg) were used to compare the relative bioavailability of Cu from CuO and CuSO4 when supplemented to corn silage-based diets high in the Cu antagonists iron (Fe) or molybdenum (Mo). Treatments consisted of no supplemental Cu or 8 mg of supplemental Cu/kg diet from either CuSO4 or CuO. Within each Cu treatment, diets were supplemented with 600 mg of Fe or 5 mg of Mo/kg diet. In calves fed 5 mg of Mo/kg, plasma Cu was lower (P < .05) in those fed no supplemental Cu or CuO compared with calves fed CuSO4 by d 91 and at subsequent sampling dates throughout the 154-d study. Plasma ceruloplasmin activity was decreased (P < .01) by Mo and was increased (P < .05) by CuSO4 compared with CuO. Based on plasma Cu and ceruloplasmin activity, CuSO4 and Cu lysine were similar in bioavailability, but CuO was essentially unavailable.
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PMID:Bioavailability of feed-grade copper sources (oxide, sulfate, or lysine) in growing cattle. 788 34