Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.16.3.1 (ceruloplasmin)
 5,074 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Clinical research was conducted with human volunteers to ascertain the effect on serum levels of 2 proteins of hepatic origin--SHBG (sex hormone binding globulin) and CP (caeruloplasmin)--of 30 mcg and 50 mcg ethinyl estradiol administered alone and the new "triphasic" formulation consisting of low doses of ethinyl estradiol and levonorgestrel. Ethinyl estradiol caused a rapid increase in the mean levels of both SHBG and CP, which showed up as early as 2-3 days after initiation of the therapy and continued beyond the time of the therapy. Even the lower dose of ethinyl estradiol caused elevation of the 2 protein levels. Even the low dose of levonorgestrel present in the "triphasic" regimen had a sufficient antiestrogenic effect to prevent marked increase in both SHBG and CP. There were no significant differences in serum levels of the proteins in the women receiving the 30 mcg or the 50 mcg dosages. However, in any individual woman, the changes occurring with 30 mcg would be less than those occurring with 50 mcg. The study showed that there are marked inter-subject variations in metabolic changes occurring as a result of exposure to steroidal contraceptives.
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PMID:Effect of contraceptive steroids on serum levels of sex hormone binding globulin and caeruloplasmin. 719 72