Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:1.16.3.1 (ceruloplasmin)
 5,074 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

12 healthy volunteers attending the family planning clinic at Shanghai, First Maternity and Infant China, Hospital, enrolled in the study, Oral contraceptives (OCs) were prescribed: Marvelon (150 mcg of desogestrel--DSG), Mercilon (150 mcg of DSG), and Microgynon (150 mcg of levonorgestrel--LNG). The patients were divided into 6 groups of 2 persons each in a randomized cross-over study. OCs were taken on day 6 of the cycle up to day 21, then stopping for 7 days. Each OC was used for 3 months. During the pretreatment cycle between days 6 and 9 of the follicular phase and 21 and 22 of the luteal phase a blood sample was taken after fasting for determination of lipids, sex hormone binding globulin (SHGB), ceruloplasmin, and testosterone. After glucose loading, significant increases of glucose and insulin occurred at 1, 2, and 3 hours during treatment with Microgynon only. The ratio for total areas of insulin to glucose did not change significantly nor did glycosilated hemoglobin A1 levels. Serum triglyceride concentrations increased significantly for both Marvelon (27%-43%) and Mercilon (29-40%). Serum high density lipoprotein (HDL) cholesterol concentrations were significantly elevated with Marvelon but less so with Mercilon, while HDL-C decreased significantly with Microgynon. The serum low density lipoprotein (LDL) cholesterol changes were not significant, but LDL-C concentrations declined with DSG formulations and increased with Microgynon. Apoprotein A1 and A2 increased significantly for both Marvelon and Mercilon. Apoprotein A2 increased with Microgynon. Serum SHBG increased markedly with Marvelon (335-380%). Serum testosterone concentrations decreased significantly (33.2-40.4% with Microgynon) and so did ceruloplasmin values. The antiestrogenic effect of strong LNG in Microgynon produced significant metabolic changes. The effect of 30 mcg EE in Marvelon and 20 mcg EE of Mercilon was equal.
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PMID:A cross-over study of three oral contraceptives containing ethinyloestradiol and either desogestrel or levonorgestrel. 153 80

116 women 21-36 years old, who had been taking oral contraceptives (OC) for at least 1 and 1/2 years and, at the most, for 4 years, were studied. The subjects underwent detailed clinical, biochemical, and immunological tests using samples of their blood sera. Their OC was Neogest consisting of .15 mg levonorgestrel and .03 mg ethinyl estradiol. Prealbumin values were higher than normal .40 g/l ) in 23 of 83 women studied. Alpha-1-antitrypsin values were below normal in 55 and above normal 4.0 g/l in 13 of 114 subjects studied. Alpha-2-macroglobulin was below normal (1.75 g/l) in 18 and above normal 4.20 g/l in 3 women of 67 studied. In 26 women, orosomucoid (alpha-1-glycoprotein) values were below normal (.55 g/l) and in 2 women the values were above normal (1.40 g/l) among 116 women. The ceruloplasmin values were below normal in 2 (.15 g/l) and above normal in 51 women (.60 g/l) of 115 studied. The effect of OCs on these proteins and possible metabolic changes and pathological associations were also addressed. All of these differences were statistically significant (p 0.01). The relationship of deviation from normal was the largest for alpha-1-antitrypsin with a below normal direction (1/1 = .482) and for ceruloplasmin with an above normal direction (1/1 = .440). The main reason of departure was the large number of above normal values in the case of prealbumin and ceruloplasmin and the large number of below normal values for alpha-1-antitrypsin, alpha-2-macroglobulin, and orosomucoid.
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PMID:[Hormonal contraception and levels of selected serum proteins]. 213 7