Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:1.16.3.1 (ceruloplasmin)
 5,074 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Primary biliary cirrhosis (PBC) patients showed increased ceruloplasmin activity and Cu content in the serum as compared to the control group. Moreover, Cu, Fe, and Zn contents were measured in the livers of autopsied cases. The PBC patients showed increased Cu content and reduced Fe and Zn levels. In PBC cases, Cu transportation via bile is disturbed due to collapse of the interlobular bile ducts and consequently Cu accumulates in the liver. Thus, it is likely that serum ceruloplasmin activity increases to metabolize the accumulated hepatic Cu and that Cu content increases in the serum as a ceruloplasmin-bound form. Furthermore, reduction of Fe and Zn contents in the liver of the PBC patients indicated the possible relationship of ceruloplasmin to Fe and Zn metabolism as well as Cu metabolism.
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PMID:Elevation of ceruloplasmin activity involved in changes of hepatic metal concentration in primary biliary cirrhosis. 793 9

Turkey poults were inoculated at hatch with the "W" isolate of Bordetella avium. At 17 d of age, serum copper levels and ceruloplasmin activities were determined. The trachea and aorta were analyzed for collagen and elastin content in an attempt to relate these structural proteins to the clinical observations of tracheal ring distortion and cardiac dysfunction associated with bordetellosis. Serum copper levels and ceruloplasmin activity were elevated in the B. avium-infected poults and indicated enzyme activity sufficient for elastin and collagen cross-link formation. In the infected poults, crude elastin content was increased significantly (0.67% infected vs 0.59% control) in the trachea but not in the aorta (13.12% infected vs 12.68% control). However, collagen content in infected poults (69.7 hydroxyproline residues per 1,000 amino acid residues) was decreased in the trachea compared to the controls (97 hydroxyproline residues per 1,000 amino acid residues), whereas collagen and elastin cross-links (HLNL, hydroxy-lysinohydroxy-norleucine, moles per mole of collagen per 300 residues hydroxyproline) were increased in the trachea of infected poults (2.85 in infected vs 1.80 in control) and also increased (DHLNL, dihydroxy-lysinohydroxy-norleucine, moles/mole of collagen/300 residues hydroxyproline) in the aorta (0.49 in infected vs 0.39 in control) of infected poults. The differences in collagen and elastin content, in association with differences in the cross-linking, appeared to be the cause of tracheal collapse that is characteristic of B. avium infection and also may have an adverse influence on cardiovascular function.
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PMID:The effects of Bordetella avium infection on elastin and collagen content of turkey trachea and aorta. 983 39

This work tested the hypotheses that splanchnic oxidant generation is important in determining heat tolerance and that inappropriate.NO production may be involved in circulatory dysfunction with heat stroke. We monitored colonic temperature (T(c)), heart rate, mean arterial pressure, and splanchnic blood flow (SBF) in anesthetized rats exposed to 40 degrees C ambient temperature. Heating rate, heating time, and thermal load determined heat tolerance. Portal blood was regularly collected for determination of radical and endotoxin content. Elevating T(c) from 37 to 41.5 degrees C reduced SBF by 40% and stimulated production of the radicals ceruloplasmin, semiquinone, and penta-coordinate iron(II) nitrosyl-heme (heme-.NO). Portal endotoxin concentration rose from 28 to 59 pg/ml (P < 0.05). Compared with heat stress alone, heat plus treatment with the nitric oxide synthase (NOS) antagonist N(omega)-nitro-L-arginine methyl ester (L-NAME) dose dependently depressed heme-.NO production and increased ceruloplasmin and semiquinone levels. L-NAME also significantly reduced lowered SBF, increased portal endotoxin concentration, and reduced heat tolerance (P < 0.05). The NOS II and diamine oxidase antagonist aminoguanidine, the superoxide anion scavenger superoxide dismutase, and the xanthine oxidase antagonist allopurinol slowed the rates of heme-.NO production, decreased ceruloplasmin and semiquinone levels, and preserved SBF. However, only aminoguanidine and allopurinol improved heat tolerance, and only allpourinol eliminated the rise in portal endotoxin content. We conclude that hyperthermia stimulates xanthine oxidase production of reactive oxygen species that activate metals and limit heat tolerance by promoting circulatory and intestinal barrier dysfunction. In addition, intact NOS activity is required for normal stress tolerance, whereas overproduction of.NO may contribute to the nonprogrammed splanchnic dilation that precedes vascular collapse with heat stroke.
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PMID:Mechanisms of circulatory and intestinal barrier dysfunction during whole body hyperthermia. 1115 46