Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.16.3.1 (
ceruloplasmin
)
5,074
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The incorporation of tritiated thymidine into
CCL
-39 cells grown in the absence of fetal calf serum or other growth factors is greatly increased by low concentrations of
ceruloplasmin
. The stimulation is greater than observed with serum or thrombin. Addition of serum decreases the thymidine incorporation with
ceruloplasmin
to the level with serum alone. As with serum, the response to
ceruloplasmin
is high at both 20% and 1% oxygen, which is consistent with the action of
ceruloplasmin
as an oxidant with a high affinity for oxygen. Since transplasma membrane electron transport increases cell growth and thymidine incorporation,
ceruloplasmin
may act as a terminal oxidase for ferrous iron or ascorbate to stimulate transplasma membrane electron transport. The four electron transfer from
ceruloplasmin
to oxygen to form water will prevent peroxide formation at the cell surface. Alternatively, superoxide formation inside the cell or membrane could employ the superoxide dismutase function of
ceruloplasmin
to produce peroxide. Either mechanism would be consistent with the previously described stimulation of growth by external oxidants.
...
PMID:Ceruloplasmin stimulates thymidine incorporation by CCL-39 cells in the absence of serum or growth factors. 195 52
