Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:1.16.3.1 (ceruloplasmin)
 5,074 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

4 groups, each of 6 healthy volunteer female subjects aged 18-40 years, participated in this study designed to determine the effect of some contraceptive steroids on 2 plasma proteins -- sex hormone binding globulin (SHBG) and ceruloplasmin (CP). The pills were taken daily for 20 days, starting within the 1st 5 days of the menstrual cycle. There was no significant difference between the groups in the pre-treatment values. In Group LNG150 (150 mcg levonorgestrel), SHBG concentrations decreased, the decrease being statistically significant both in actual concentration and percentage change within 2-3 days of starting treatment. As pill-taking continued, SHBG concentrations declined further, and by the end of the treatment period they were less than half of the pretreatment value. Recovery was slow. In group EE30, LNG150 (ethinylestradiol 30 mcg and levonorgestrel 150 mg), no significant change occurred in SHBG concentrations during treatment. In Group EE35, NET1000 (ethinylestradiol 35 mcg and norethisterone 1000 mcg), SHBG increased, the value on days 2-3 of treatment being significantly higher than pretreatment. A steady state appeared to have been reached by days 7-8 and for the remainder of the treatment period the increase varied from 180-200% of the pretreatment value. The return to pretreatment values was slow. Women in Group EE35, NET600 (ethinylestradiol 35 mcg and norethisterone 600 mcg) also showed a rise in SHBG concentrations, which was greater than that observed in Group EE35, NET1000. In Group LNG150, CP concentrations slowly decreased during pill-taking, but the decrease did not reach statistical significance until days 14-15 of treatment; at this time the concentrations were about 15% lower than pretreatment. Despite stopping treatment, concentrations continued to decrease and were more than 25% lower by day 8 posttreatment. In Group EE30, LNG150, CP concentrations were significantly higher than pretreatment by days 2-3 and values continued to increase to the day of treatment. Women in Groups EE35, NET 1000 and EE35, NET600 showed a similar pattern, but the maximum percentage increase was higher, about 100%, compared to 75% in Group EE30, LNG150. Differences in the responses of ostensibly closely related proteins of hepatic origin, i.e., SHBG and CP, to the OCs demonstrate that neither can be extrapolated to other pharmacodynamic responses.
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PMID:Effect of some oral contraceptives on serum concentrations of sex hormone binding globulin and ceruloplasmin. 249 34