Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.16.3.1 (ceruloplasmin)
 5,074 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Alpha-1-antitrypsin was demonstrated both by immunofluorescence and immunoperoxidase techniques in the peripheral islet cells of 15 normal human pancreases, processed freshly and after embedding in paraffin. Normal human liver obtained from the same patients was negative. The immunohistochemical reactions were stronger in frozen sections than in paraffin material. However, immunoperoxidase staining on paraffin sections permitted a more precise localization of positive cells. The specificity of the immunohistochemical reactions was confirmed by applying various control tests including a absorption of the specific antisera with purified alpha-1-antitrypsin, inhibition and blocking tests. Further examination of pancreatic tissue for the presence of various immunoglobulins, alpha-1-lipoproteins, alpha-1-acid glycoproteins and ceruloplasmin were negative. These findings suggest that the pancreatic islets may be an extra source of alpha-1-antitrypsin.
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PMID:Immunohistochemical demonstration of alpha-1-antitrypsin in the islet cells of human pancreas. 20 15

Alpha-1-antitrypsin, alpha-2-macroglobulin, C-reactive protein, haptoglobin and complement component C 3 concentrations and oxidase activity of ceruloplasmin were studied in sera of 36 patients with chronic periapical granuloma before and after surgical treatment. Mean serum concentrations of the investigated proteins were slightly elevated at diagnosis, with the exception of haptoglobin. Alpha-1-antitrypsin and ceruloplasmin levels decreased significantly 7 days after apicectomy, the four other proteins were unchanged at this sampling time. Each investigated protein decreased significantly 3 months after apicectomy. This is the first longitudinal study of "acute-phase proteins" in chronic periapical granuloma. The results suggest that inflammatory reactions contribute to the maintenance of chronic periapical lesion.
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PMID:[The role of acute phase proteins in the pathogenesis of chronic periapical granuloma]. 169 64

116 women 21-36 years old, who had been taking oral contraceptives (OC) for at least 1 and 1/2 years and, at the most, for 4 years, were studied. The subjects underwent detailed clinical, biochemical, and immunological tests using samples of their blood sera. Their OC was Neogest consisting of .15 mg levonorgestrel and .03 mg ethinyl estradiol. Prealbumin values were higher than normal .40 g/l ) in 23 of 83 women studied. Alpha-1-antitrypsin values were below normal in 55 and above normal 4.0 g/l in 13 of 114 subjects studied. Alpha-2-macroglobulin was below normal (1.75 g/l) in 18 and above normal 4.20 g/l in 3 women of 67 studied. In 26 women, orosomucoid (alpha-1-glycoprotein) values were below normal (.55 g/l) and in 2 women the values were above normal (1.40 g/l) among 116 women. The ceruloplasmin values were below normal in 2 (.15 g/l) and above normal in 51 women (.60 g/l) of 115 studied. The effect of OCs on these proteins and possible metabolic changes and pathological associations were also addressed. All of these differences were statistically significant (p 0.01). The relationship of deviation from normal was the largest for alpha-1-antitrypsin with a below normal direction (1/1 = .482) and for ceruloplasmin with an above normal direction (1/1 = .440). The main reason of departure was the large number of above normal values in the case of prealbumin and ceruloplasmin and the large number of below normal values for alpha-1-antitrypsin, alpha-2-macroglobulin, and orosomucoid.
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PMID:[Hormonal contraception and levels of selected serum proteins]. 213 7

In order to evaluate the behaviour of some acute phase proteins in chronic pancreatic disease and to correlate these reactants with different factors, C-reactive protein, ceruloplasmin and alpha-1-antitrypsin were assayed in the sera of 24 control subjects, 26 patients with pancreatic cancer, 22 patients with chronic pancreatitis and 22 patients with a variety of diseases not of pancreatic origin. Alpha-1-antitrypsin, C-reactive protein and ceruloplasmin concentrations were found to be increased in 63%, 50% and 42% of patients with chronic pancreatic disease, respectively. In patients with pancreatic cancer no difference was found between the values of each protein considering the presence or otherwise the absence of liver metastases. Patients with chronic pancreatitis had higher C-reactive protein or alpha-1-antitrypsin values when increased serum amylase or pseudocysts were present. Significant correlations were found between the three acute-phase proteins considering the subjects as a whole; however in the single subjects they were not found to be concomitantly abnormal. Correlations were detected between these proteins and liver function test values. Alpha-1-antitrypsin is probably the most sensitive index in chronic pancreatic disease, while C-reactive protein seems better to reflect the stage of the disease. The variations of the levels of these proteins seem to be, at least in part, independent of each other; they are all partially influenced by the presence of liver damage.
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PMID:Acute phase proteins in chronic pancreatic disease. 248 37