Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: EC:1.16.3.1 (ceruloplasmin)
5,074 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The introduction deals with of the history, etiology and, briefly, clinical manifestations of endemic nephropathy. The authors state that a large number of investigations have been done until today, but without producing a diagnostic test for early diagnosis of the disease. This led the authors to pursue certain laboratory investigations. The control group consisted of 30 healthy individuals while patients diagnosed as Endemic Nephropathy were grouped according to stages of the disease: initial, developed, terminal stages. Nucleotides in erythrocytes (5' UMP, 5' IMP, 5' GMP, 5,CMP, 5' AMP, 5' ADP, 5' ATP) were determined on the Acidic Aminoanalyzer, with use of a special UV detector. Catecholamines in the urine were determined by using ratiofluorometery. Creatinine phosphocinase, hydroxybutirat--dehydrogenase and 2,3 DPG were determined on the "Carlbiochem" enzymometer. LDH, its isoenzymes as well as its profile were determined by electrophoresis on starch gel. Specific proteins such as haptoglobin, alpha 2 macroglobulin, alpha 1 antitrypsin, alpha 1 acid glycoprotein, properdin factor B, ceruloplasmin were determined on the Immunochemistry Analyzer. Total cholesterol and cholesterol in lipoproteins fractions VLDL, LDL and HDL were determined on the Cholesterol Analyzer. All results were evaluated statistically. Our conclusion is that they are interesting and contribute to the diagnosis of endemic nephropathy.
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PMID:[Levels of immunoglobulins in various media from healthy pregnant women and women with diabetes mellitus and EPH gestosis]. 191 49

The efficacy of a drug containing three heavy metals together has been tested in adjuvant-induced arthritic rats. Treated rats were injected with 22.8 micrograms copper gluconate, 0.2 microgram gold thioglucose and 6.8 micrograms silver proteinate each day during a period of 29 days. The drug treatment was found to diminish the increases in plasma levels of haptoglobin, ceruloplasmin, PGE2, 6-keto-PGF1 alpha and copper, the decrease in the iron plasma level induced by Freund's adjuvant and the paw swelling. No effect was seen on the plasma levels of TXB2, Zn, Se, Mn and Ni. Therefore the simultaneous administration of low doses of gold, copper and silver had a real anti-rheumatic property in this model. These results should be of interest for the long-term treatment of arthritis.
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PMID:Anti-inflammatory properties of a preparation containing low doses of copper, gold and silver. 198 Sep 12

The indices of immunity and acute phase reaction in 89 men exposed for 2 to 26 years to mercury vapours were assessed on the basis of immunoglobins, lysozyme, C3c, C4, alpha 1-acid glycoproteins, haptoglobin and ceruloplasmin concentrations in blood serum. Urinary mercury concentration amounted to 73 +/- 60 micrograms x l-1 whereas in blood it did not exceed 50 micrograms x l-1. A decrease in concentration of IgA, IgG and lysozyme in persons who worked for over 20 years was found. The observed phenomenon did not affect the anti-infection and antitumor immunity of the workers.
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PMID:[Indicators of immunity and acute phase reaction in men in relation to the duration of exposure to mercury vapors]. 212 72

Immunological studies were carried out in 85 male smokers smoking 15-25 cigarettes daily for 2-25 years, and in 49 non-smokers. Cigarette smoking for a period longer than 10 years caused a fall of IgA, IgG, IgM and lysozyme concentrations. On the other hand, the levels of C3c and C4 components of complement, alpha 1-acid glycoprotein, ceruloplasmin, haptoglobin and antistreptolysin O were normal. Impairment of immunity to infections and neoplasms in cigarette smokers may be related to deficiency of various proteins responsible for normal course of immune processes of the organism.
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PMID:[Indicators of humoral immunity and acute phase reaction in cigarette smokers]. 212 45

Adult male Sprague-Dawley rats with streptozotocin-induced diabetes (6 to 8 wk duration), treated or untreated with insulin, were studied with two aims: (a) to ascertain whether protracted diabetes in the rat is associated with changes in circulating plasma protein levels analogous to those reported in human diabetic patients with clinical evidence of complications; (b) to evaluate the effects of experimental diabetes on the net cumulative biosynthesis of 10 specific plasma proteins by the isolated liver, perfused for 24 hr. Samples of liver donor plasma and samples of perfusate were analyzed by single radial immunodiffusion or by rocket immunoelectrophoresis for albumin, alpha 1-macroglobulin and the acute phase glycoproteins: fibrinogen, alpha 1-acid glycoprotein (Darcy), alpha 1-acid glycoprotein (Kawasaki), haptoglobin, alpha 2-(acute phase) globulin, hemopexin, C3-complement and ceruloplasmin. Diabetes (6 to 8 wk), untreated with insulin, resulted in significantly increased liver donor plasma levels of alpha 1-acid glycoprotein (Darcy) and alpha 1-acid glycoprotein (Kawasaki); plasma levels of hemopexin and of C3 decreased to 75% and 30% of normal, respectively. Insulin treatment of diabetic liver donors for 6 to 8 wk prevented the increase in alpha 1-acid glycoprotein (Darcy) and alpha 1-acid glycoprotein (Kawasaki) and minimized the decrease in C3 to 75% of normal. Perfused livers from untreated diabetic rats (6 to 8 wk) showed slightly decreased cumulative synthesis and secretion of alpha 1-acid glycoprotein (Darcy); however, synthesis of albumin was reduced to 35% of normal and that of eight glycoproteins ranged from 25% of normal (fibrinogen) to 12% of normal (C3). The striking in vitro induction of increased synthesis of acute-phase proteins by cortisol plus insulin in the isolated perfused normal liver was in contrast to the severely attenuated induction in perfused livers of untreated diabetic rats, which ranges from 50% of normal for alpha 1-acid glycoprotein (Darcy) to 5% of normal (C3). Severely negative perfusate nitrogen balance and impaired glucose utilization by perfused untreated diabetic livers contrasted with positive nitrogen balance and good glucose utilization of normal livers in response to insulin plus cortisol. The plasma protein synthetic capacity and the in vitro response to insulin plus cortisol of perfused livers from insulin-treated diabetic rats were normal for seven of the proteins but moderately decreased for albumin, haptoglobin and C3.
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PMID:Effects of streptozotocin diabetes in the rat on blood levels of ten specific plasma proteins and on their net biosynthesis by the isolated perfused liver. 213 29

The antioxidants in the aqueous phase of human plasma include ceruloplasmin, albumin (the protein itself and possibly also albumin-bound bilirubin), ascorbic acid, transferrin, haptoglobin, and hemopexin. Assays that attempt to answer the question "what is the most important antioxidant?" are compared, it being concluded that the answer is different depending on the nature of the prooxidant stress imposed in the assay.
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PMID:The antioxidants of human extracellular fluids. 219 27

Four bearer-proteins including prealbumin (Pal), ceruloplasmin (CP), transferrin (Tf) and haptoglobin (HP) and C3 were determined in patients following burn injury. The patients were divided into 4 groups according to the TBSA, i.e. group 1 (1-10%), group 2 (11-30%), group 3 (31-60%) and group 4 (61-98%). Early after burn injury Pal, CP, Tf and C3 decreased markedly but C3 and CP were followed by a elevation slightly higher than normal control in group 1 and 2 but not in group 3 and 4, while Tf and Pal kept in lower level till 4 weeks after burn injury. Only elevated HP after burn injury was noticed and then decreased in group 1 and 2.
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PMID:[Changes in 4 bearer-proteins and C3 in patients following burn injury]. 228 92

Retinol-binding protein, haptoglobin and ceruloplasmin were determined in the plasma of patients with colorectal carcinoma. The comparison with a control group shows that retinol-binding is significantly decreased in colorectal carcinoma and that haptoglobin and ceruloplasmin are significantly elevated. The ROC-curves of the three parameters, however, display a sensitivity distinctly lower than that of CEA, so that any use in the clinical treatment of colorectal carcinoma cannot be expected from the determination of these substances.
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PMID:[Retinol-binding protein, haptoglobin and ceruloplasmin--tumor markers in colorectal cancer?]. 232 34

The haptoglobin serum group 2-2 has a preponderance in affective psychoses (p less than 0.0005). This genetic marker trait is extended on unipolar depressions (p less than 0.005) and cycloid psychoses (p less than 0.0005). In addition, it must be assumed that the serum levels of albumin (p less than 0.0001), ceruloplasmin (p less than 0.0001) and haptoglobin (p less than 0.0001) are increased in affective disorders. Besides, the transferrin serum values are decreased in cycloid psychoses (p less than 0.001). As ascertained in a supplementary study, Hp 2-2 is associated within the normal range of variation with the highest albumin serum levels already in healthy controls when compared with Hp 1-1 (p less than 0.05) and Hp 2-1 (p less than 0.001). Even after including the extreme variants, the Hp 2-2 sera display more albumin values above 40.8 g/l than the Hp 2-1 specimens and the summarized samples of Hp 1-1 and Hp 2-1 (p less than 0.02). Furthermore the Hp 2-2 sera exhibit higher ceruloplasmin levels than the samples of Hp 1-1 (p less than 0.01) and Hp 2-1 (p less than 0.005). These differences are persisting too in the same trend after including extreme high ceruloplasmin values (p less than 0.05 and p less than 0.005 respectively). Obviously there are several possibilities for Hp 2-2 to operate on the biological background of affective psychoses as a risk factor. The findings are interpreted with reference to the actual data concerning the activities of the haptoglobin genes and proteins.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Distribution of serum haptoglobin groups in affective psychoses--more than a genetic marker indication?]. 233 28

The main requirements for the dietotherapy of rheumatoid arthritis (RA) patients have been formulated, and for the first time a pathogenetically balanced diet has been developed that produces antiinflammatory and immunocorrective effects. The effectiveness of the dietotherapy included into the combined treatment was studied in 41 patients with classic and proved RA. The authors have studied the influence of the dietotherapy on the clinical signs characterizing the activity of inflammation in the joints, and laboratory immunological parameters (IgG, IgM, IgA, IgD, the complement components: C1-inhibitor, C3, C4, C5, C9; haptoglobin, orrhozomucoid, transferrin, ceruloplasmin, alpha 1-antitrypsin, alpha 2-macroglobulin, prealbumin). The results of the study have shown that the dietotherapy is not only conducive to the improvement of the clinical picture of the disease, that permits diminishing the amount of nonsteroid antiinflammatory drugs used, but also produces a favourable effect on the RA patients' immunological state. It has been concluded that inclusion of the dietotherapy into the combined treatment of RA patients is advisable.
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PMID:[The effect of dietotherapy on the clinico-immunological indices of rheumatoid arthritis patients]. 234 5


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