Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:1.16.3.1 (ceruloplasmin)
 5,074 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The serum concentration of four acute phase reactant proteins (haptoglobin, sialic acid, alpha 1-antitripsin, ceruloplasmin) were determined in 160 patients with laryngeal cancer. In 50 cases treated by surgery serial determinations were performed. The control group included healthy persons and patients with non-neoplastic diseases. The levels of haptoglobin, alpha 1-antitripsin and sialic acid were significantly higher in cancer patients than in control group. The levels of ceruloplasmin reveals no statistically significant difference between particular groups of patients. The serum concentrations of haptoglobin, alpha 1-antitripsin and sialic acid correlated with the clinical status of cancer patients. We suggest that serial determination of certain acute phase reactant proteins may be useful as a prognostic acid in following patients with laryngeal carcinoma.
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PMID:Acute phase reactant proteins--an aid to monitoring surgical treatment of laryngeal carcinoma. 138 9

According to Ravin's method an oxidative activity of ceruloplasmin was determined in the group of patients with carcinoma of the larynx before and after a surgical treatment, in the group of patients with inflammatory lesions in the upper respiratory tract and in the control group of healthy individuals. As a result of this assay the significantly increased of oxidative activity ceruloplasmin was obtained in the individuals with the carcinoma of the larynx (before surgical treatment) in comparison to the group of patients suffering due to inflammatory diseases of the upper respiratory tract and to the group of healthy subjects. Simultaneously a significant decrease of the oxidative activity of serum ceruloplasmin in the individuals with carcinoma of the larynx after a previous surgical treatment was observed.
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PMID:[Determination of oxidative activity of ceruloplasmin using Ravin's method in patients with laryngeal carcinoma]. 143 72

The ceruloplasmin activity of serum was measured in 50 patients with larynx cancer and 50 healthy subjects. The determination of serum ceruloplasmin based on the diamine oxidase activity with o-dianisidine as a substrate. In patients with laryngeal cancer the ceruloplasmin activity was significantly higher than that in healthy controls. The increase in the ceruloplasmin activity was correlated with clinical stage of larynx cancer.
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PMID:[Serum ceruloplasmin activity in patients with cancer of the larynx]. 150

Acute phase proteins (APP) increase by the chemical receptors of macrophage via stimulations of either Fc or complement or other chemical receptors. No differences of APP pattern were observed by the different stimulants, because the effects of stimulation are changed by many processing steps in the macrophage as well as in the liver cell thereafter. Whether the APP increase results in good prognosis for original sickness or not are examined by multiple regression analysis in 38 cases of maxillary and 51 cases of laryngeal cancer with the observation for over five years. Alpha 1X contributes positively with length of their life, whereas alpha 1AG and ceruloplasmin contribute negatively. We could say that not all components of APP increase are advantageous for the diseases.
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PMID:[Biosynthesis and significance of acute phase proteins]. 169 27

According to Ravin's method an oxidative activity of ceruloplasmin was determined in the group of patients with carcinoma of larynx before and after rtg-therapy and at the control group of healthy individuals. As a result of this assay the significantly increased of oxidative activity ceruloplasmin was obtained in the individuals with the carcinoma of the larynx before rtg-therapy in comparison to the group of healthy subjects. Simultaneously a significant decrease of the oxidative activity of serum ceruloplasmin in the individuals with carcinoma of the larynx after rtg-therapy was observed.
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PMID:[Oxidase activity in patients with laryngeal carcinoma treated by radiotherapy]. 975 22

The levels of 21 protein components of the sera of 45 patients with cancer of the larynx undergoing radiation therapy were determined by a single radial immunodiffusion method before and after radiation therapy. We examined the correlation between changes in serum protein fractions and the prognosis of the patients. The patients with cancer of the larynx were treated with external irradiation of 60Co gammer-rays. Total target doses were 60 Gy. The levels of the same protein components were also measured in 43 normal adult individuals as a control. All patients were observed for 5 years and 12 years following radiation therapy. In the pretreatment sera obtained from patients with cancer of the larynx, the concentrations of prealbumin (Prealb), antithrombin III (ATIII) and plasminogen (Pmg) were significantly lower than controls. However the concentrations of alpha 1-acid glycoprotein (alpha 1AG), alpha 1-antitrypsin (alpha 1AT), alpha 1-antichymotrypsin (alpha 1X), haptoglobin (Hp), fibrinogen (Fib) and hemopexin (Hx) were elevated. At the completion of radiation therapy, the alpha 1AG, alpha 1AT, alpha 1X, Hp, Fib and inter alpha trypsin inhibitor (I alpha I) were significantly elevated than those normal controls. In patients without recurrent cancer after radiation therapy, the alpha 1AT, ceruloplasmin (Cp), Fib, IgA and Hx levels measured before radiation therapy were significantly lower than those patients with recurrent cancer. In patients without recurrent cancer after radiation therapy, the alpha 1AT, Hp, Cp, IgG, and IgA levels measured after radiation therapy were reduced compared with those patients with recurrent cancer. In patients who had lived more than 5 years after radiation therapy, the alpha 1AT, Cp and Fib levels measured before radiation therapy reduced significantly compared with those who had died within 5 years. In those who had lived more than 5 years, the alpha 1AG, alpha 1AT, Hp, Fib, IgG, and IgA levels measured after radiation therapy were reduced significantly compared with those who died within 5 years. In cases of laryngeal cancer following a period of 5 to 12 years after radiation therapy, multiple regression analysis was used to determine whether increased concentrations of serum protein fractions were associated with good prognosis for the original disease. AT III, Prealb, alpha 1AG, albumin (Alb) and I alpha I before radiation therapy were positively correlated with survival, whereas Hx, Pmg, Cp, IgM, Cl inhibitor (ClInh), alpha 1AT and Fib showed negative correlations. After radiation therapy, transferrin (Tf), Cp, Prealb, AT III and I alpha I were found to be positively associated with survival, whereas IgA, IgM, Pmg, alpha 1X and alpha 1AG were negative factors. From the elevation levels of acute phase proteins (alpha 1AT, Cp) and Fib and immunoglobulins (IgA, IgM) in the serum and lower levels of Prealb and AT III before and after radiation therapy, we may predict a relatively poor prognosis in these patients of laryngeal cancer.
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PMID:[Serum protein fractions in patients with laryngeal cancer undergoing radiation therapy. Possibility as a prognostic factor]. 1019 63

In this study, we investigated the levels of serum Zn, Cu, Mg, Mn, Fe, ceruloplasmin (Cp), transferrin (Trf), and albumin in laryngeal carcinoma and correlated their levels with the cancer stage. The sera from 35 patients with laryngeal cancer (10 at stage II, 12 at stage III, and 13 at stage IV) were extracted before treatment and compared with those from the healthy control group (n=15). Although serum Fe and Mn concentrations were lower in the laryngeal cancer groups (for all stages) than in the control group, the difference was not statistically significant (p>0.05). The higher Cu (p<0.001) and Cp (p<0.01) and lower Zn (p<0.01), Mg (p<0.001), and Trf (p<0.01) concentrations were found in laryngeal cancer groups (for each stage) when compared to the control group. In the comparison of stages II, III, and IV (with each other), all parameters were found to be statistically not significant (p>0.05). On the other hand, no meaningful difference was found in terms of the serum albumin level. In our opinion, alterations in the level of trace elements and antioxidant proteins, important for many metabolic processes, in laryngeal cancer may not be a reason for but is, in fact, a consequence of the disease itself.
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PMID:Trace elements and some extracellular antioxidant protein levels in serum of patients with laryngeal cancer. 1271 25