Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.16.3.1 (
ceruloplasmin
)
5,074
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Ceruloplasmin is a copper-binding protein, which is the major
ferroxidase
in plasma of hepatic origin. We now provide evidence for a novel membrane-bound form of
ceruloplasmin
expressed by astrocytes in the mammalian central nervous system. Using a monoclonal antibody (1A1), we show that the
cell surface antigen
recognized by this antibody is
ceruloplasmin
and that it is directly anchored to the cell surface via a glycosylphosphatidylinositol (GPI) anchor. Our peptide mapping and other immunochemical studies indicate that, except for the GPI anchor, the membrane-bound and secreted plasma forms are similar. We also show that the membrane-bound form of
ceruloplasmin
has oxidase activity. These studies therefore suggest that the GPI-anchored form of
ceruloplasmin
may play a role similar to the secreted form in oxidizing ferrous iron. The GPI-anchored form of
ceruloplasmin
expressed by astrocytes is likely to be the major form of this molecule in the central nervous system because serum
ceruloplasmin
does not cross the blood-brain barrier. Lack of this form of
ceruloplasmin
in the central nervous system could lead to the generation of highly toxic free radicals, which can cause neuronal degeneration as seen in aceruloplasminemia and other neurodegenerative diseases such as Parkinson's and Alzheimer's disease.
...
PMID:A novel glycosylphosphatidylinositol-anchored form of ceruloplasmin is expressed by mammalian astrocytes. 924 95
