Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:1.16.3.1 (ceruloplasmin)
 5,074 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a series of 100 adult patients with definite rheumatoid arthritis of at most 3 years' duration and with no previous penicillamine, gold or systemic corticosteroid treatment, 50 patients were treated with D-penicillamine and 50 with gold for one yar. The dose of penicillamine was 600 mg daily. Sodium aurothiomalate was given 50 mg weekly up to a total of 13 mg/kg and thereafter 50 mg once a month. In both treatment groups a statistically significant decrease in the number of painful and/or swollen joints, an increase in haemoglobin and a decrease in ESR, serum ceruloplasmin-, alpha1-acid glycoprotein-, IgG-, IgM- and IgA levels was observed. All the changes in these clinical and laboratory tests were of the same degree in both treatment groups. In the penicillamine group 12 out of 20 seropositive patients became seronegative and in another 5 the Waaler-Rose titre dropped clearly. In the gold group, 7 out of 16 seropositive patients became seronegative, and the Waaler-Rose titre dropped in another 5. An equal increase in the number of eroded joints in hands and toes was seen in the penicillamine and the gold group. Penicillamine was discontinued because of side effects in 13 patients (26%), and gold treatment in 15 (30%). Proteinuria and/or haematuria were the most common causes of discontinuation in the penicillamine group.
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PMID:Comparison of penicillamine and gold treatment in early rheumatoid arthritis. 10 90

The interaction between lyophilized samples of ascorbic acid and some copper proteins (ceruloplasmin, cytochrome-c-oxidase, ascorbate-oxidase) has been investigated by means of ESR spectroscopy. The spectra obtained are identical to the one obtained with leukemic blood. The consequences of this for the molecular events occurring in cancer are discussed. The model proposed can explain the experimental findings reported thus far (such as change in spin concentration with the development of cancer, the presence of a high concentration of antioxidants etc.) as well as reconsile the two existing and seemingly contradictory hypothesis. Possible implications for lipid peroxidation and for the respiratory process are discussed.
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PMID:On the possible involvement of ascorbic acid and copper proteins in leukemia. IV. ESR investigations on the interaction between ascorbic acid and some copper proteins. 22 87

In a controlled therapeutic trial 17 patients with active rheumatoid arthritis (stage II and III) were divided in two randomized groups. One group of 9 patients was treated with 900 mg of D(-)penicillamine (Trolovol) plus 1500 mg of salicylate per day, the other group of 8 patients with 10 mg of prednisolone plus 1500 mg of salicylate daily. Before and after 1, 2, 3, 4 and 6 months of treatment IgA, IgG, IgM and caeruloplasmin were estimated with immunodiffusion technique. In both groups the IgA and IgG levels remained unchanged; unter D-penicillamine, on the contrary, a statistically significant and continuous fall of IgM and caeruloplasmin was observed; prednisolone treatment induced only a temporary fall of caeruloplasmin. In the DPA treated patients, a significant correlation of IgM with caeruloplasmin and of caeruloplasmin with ESR was found. In both groups there was no correlation between joint count and caeruloplasmin, joint count and IgM, caeruloplasmin and copper, copper and ESR; in the prednisolone group no correlation between caeruloplasmin, ESR and IgM was observed. The correlations suggest that the remarkable fall of IgM and caeruloplasmin under D(-)penicillamine treatment is caused at least partially by direct interference of DPA with these plasma proteins.
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PMID:[Ceruloplasmin and immunoglobulins under controlled D-penicillamine therapy in rheumatoid arthritis]. 126 22

Immune arthritis in sensitized rabbits was induced by intraarticular injection of bovine serum albumin. The development of the arthritis was accompanied by an increase in ESR, a rise of the level of serum CRP, caeruloplasmin and CIC. A chemiluminescent response of the whole blood phagocytes to stimulation by barium sulfate crystals, serum beta-glucuronidase and red cell superoxide dismutase activity enhanced, plasma malone dialdehyde content rose, serum SH groups diminished.
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PMID:[The effect of intra-articular emoxipin injections on the course of immune arthritis in rabbits]. 128

The diabetogenic action of alloxan is believed to involve oxygen free radicals and iron. Incubation of glutathione (GSH) and alloxan with rat liver ferritin resulted in release of ferrous iron as assayed by spectrophotometric detection of ferrous-bathophenanthroline complex formation. Neither GSH nor alloxan alone mediated iron release from ferritin. Superoxide dismutase (SOD) and catalase did not affect initial rates of iron release whereas ceruloplasmin was an effective inhibitor of iron release. The reaction of GSH with alloxan resulted in the formation of the alloxan radical which was detected by ESR spectroscopy and by following the increase in absorbance at 310nm. In both instances, the addition of ferritin resulted in diminished alloxan radical detection. Incubation of GSH, alloxan, and ferritin with phospholipid liposomes also resulted in lipid peroxidation. Lipid peroxidation did not occur in the absence of ferritin. The rates of lipid peroxidation were not affected by the addition of SOD or catalase, but were inhibited by ceruloplasmin. These results suggest that the alloxan radical releases iron from ferritin and indicates that ferritin iron may be involved in alloxan-promoted lipid peroxidation.
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PMID:Alloxan- and glutathione-dependent ferritin iron release and lipid peroxidation. 253 98

The intensity of the ESR signal of methemoglobin, Fe3+-transferrin, and Cu2+-ceruloplasmin in blood and spleen of mice exposed to 6 Gy radiation was shown to undergo considerable changes at early times of acute radiation sickness.
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PMID:[EPR study of the blood of animals during an acute radiation lesion]. 302 43

Radiographs of hands and feet were obtained from 125 consecutive patients with rheumatoid arthritis (RA) and the degree of destruction was assessed numerically on a 200-point scale using Larsen's standard radiographs as reference. The method is shown to possess a satisfactory degree of reproducibility. In 96 of these 125 patients, values of another 15 simultaneously determined clinical and biochemical variables were obtained. On applying linear and quadratic multiple regression analysis to this set as well as to the male and female subsets, an 'automatic' selection procedure (stepwise regression) proved duration of disease to be the most important factor relating to the 'Larsen index'. The 96 patients were therefore ranked with respect to duration of disease and divided into 4 subsets of equal magnitude. In the 3 subsets with duration of disease less than 21 years, stepwise regression produced in the final step linear or quadratic combinations not containing duration of disease but correlating quite well with the 'Larsen index' (R = 0.64-0.96). A similar result was obtained upon performing an analogous procedure in the female subset. In all instances, positive contributions of varying degree were obtained from Ritchie's index, ESR, a-antitrypsin (A1-AT), orosomucoid, fibrinogen, and IgM, while negative correlations were associated with ceruloplasmin, IgG, and IgA.
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PMID:Radiographic assessment in relation to clinical and biochemical variables in rheumatoid arthritis. 326 30

Several constituents of serum and related substances were examined in order to find factors influencing ascorbate radical formation. Human ceruloplasmin and albumin catalyzed singly ascorbate oxidation and caused a remarkable increase in ESR intensity of the ascorbate radical. Although, however, the combination of these two factors showed synergic effects on catalysis of ascorbate oxidation, the radical intensity significantly decreased. Fibrinogen and fetuin showed inhibitory effects on catalysis of ascorbate oxidation, whereas transferrin, citric acid, or other related substances exhibited no effect. A new factor which inhibited ascorbate oxidation was found in a serum fraction. These results indicate there is a counterbalanced equilibrium in the redox process of ascorbate in serum and the intensity of ascorbate radical is influenced by the summation of the complicated effects of many factors.
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PMID:Factors influencing ascorbate free radical formation. 399 30

Experimental rabbits were fed cholesterol during three months. The amount of cholesterol, lipid peroxidation products, and the ratio of the ESR signal of ceruloplasmin to one of transferrins (Cp/Tf) increased in the serum of experimental rabbits as compared with the control group animals. The animals with the high Cp/Tf ratio had a low cholesterol level and a low concentration of lipid peroxidation products in the serum. The increased Cp/Tf ratio in the serum may be explained by the elevation of the Cp and Tf antioxidant activity. The rise of the antioxidant activity may be referred to the defence reaction of the body toward hypercholesterolemia.
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PMID:[The antioxidant system of transferrin-ceruloplasmin in experimental hypercholesterolemia]. 609 51

The levels of 8 acute phase reactants (alpha 1-antitrypsin, alpha 2-macroglobulin, transferrin, alpha 1-acid glycoprotein, C-reactive protein, ceruloplasmin, haptoglobin and the third component of complement) and immunoglobulin in the IgG, IgM and IgA classes were assayed, by laser nephelometry, in sera from 107 East Japanese patients with smear-positive pulmonary tuberculosis and 144 healthy subjects. These levels were correlated with clinical, haematological and radiological features, the levels of antibody to Mycobacterium tuberculosis, and the diameters of the tuberculin skin test read at various times. Levels of all acute phase reactants increased significantly in tuberculosis except for that of transferrin which was lowered. The correlations between the various acute phase reactants in health and disease were calculated. In general, the correlations were lower in disease than in health, except for the third component of complement and a greatly increased correlation between the levels of alpha 1-antitrypsin and ceruloplasmin. There was a significant correlation between levels of some of the acute phase reactants and those of antibodies to M. tuberculosis, mainly with IgG, less with IgA and least with IgM antibodies. By contrast correlations between acute phase protein and total immunoglobulin levels were most evident in the IgM class, less with IgA and not at all with IgG. Although there were some associations between protein levels and age, sex and weight of controls and patients, these were not great enough to account for the differences between the two groups. There was a tendency for patients, but not controls, with intestinal helminthiasis to have higher levels of total IgM than those without evidence of parasites. In general, the levels of proteins bore very little relation to the clinical and radiological features of disease and were, with the exception of the antimycobacterial antibodies, of no diagnostic value. Likewise, protein levels were not associated with the extent of disease; better correlations were found with the ESR and leucocyte count. Transferrin levels tended to be higher in those with chronic disease and showed a correlation with the diameters of the dermal reactions to tuberculin at 24 hours, which were also significantly larger in chronic disease. Among the haematological findings, the most significant was a negative correlation between the lymphocyte count and haptoglobin levels in disease, suggesting a possible regulatory role for this protein.
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PMID:A study of acute-phase reactant proteins in Indonesian patients with pulmonary tuberculosis. 642 16


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