Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.16.3.1 (ceruloplasmin)
 5,074 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In four areas with different types of atmospheric pollution 534 children of school age were examined for serum immunoglobulins (IgG, IgA, IgM and IgE), saliva IgA (sIgA), lysozymes (LYS) and acute phase reactants (alfa-l-antitrypsin - A1AT, alfa-2-macroglobulin -A2M, ceruloplasmin -CPL, transferrin - TRF). The children were divided into two groups: those with altered resistance (AR) comprising allergoses of all types and recurrent or persistent infections and those without the above health problems, i.e. healthy (H). There were more children with AR in areas with higher atmospheric pollution than in control areas. The frequency of AR was higher among boys than among girls. In the control area BN, a number of parameters in the AR group differed significantly from those in the H group. In areas with substantial atmospheric pollution these differences were generally less pronounced. Significant differences were found between the control and polluted areas in many indicators. In the area KO characterized by an intermediate degree of industrial pollution the means of the tested parameters were habitually elevated, whereas in the heavily polluted areas they were decreased. The most sensitive tests for evaluating differences between the areas were the levels of A1AT, LYS, and IgE, while the variations of sIgA, sLYS and CPL were less pronounced.
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PMID:Immunoglobulins and some serum proteins in children with altered resistance coming from areas with variously polluted atmosphere. 235 15

In autumn and spring a group of 132 ten-year-old school children (54.5% from families of smokers) were examined for blood content of immunoglobulins (IgG, IgA, (gM, in autumn including also IgE), lysozyme (LYS) and the so called acute reactants (alpha-1-antitrypsin = A1AT; alpha-2-macroglobulin = A2M; transferrin = TRF; ceruloplasmin = CPL); and for saliva sIgA and sLYS. Autumn examination detected significantly higher mean values of IgE in children from families of smokers, while other mean differences remained insignificant. Spring examination revealed significant differences in the means of IgA levels children from families of smokers (FS) had significantly lower levels of IgA while their saliva sIgA values were significantly higher. Mean spring CPL levels in FS were significantly higher. Analysis of distribution curves of autumn examination showed a significant shift of A1AT towards higher values in boys from FS. Girls from FS exhibited a shift of LYS towards lower values. Spring examination in boys FS evidenced a shift of CPL and sIgA values towards higher values; the curve of serum IgA levels split distinctly into two subgroups. In girls from FS the only change observed during the spring examination was a shift of A2M levels towards higher values with an indication of a split. To conclude, passive smoking in school children is responsible for a number of significant changes, the latter being more frequent and marked in spring when the children's organism is weakened by many other unfavourable circumstances. More significant changes were seen in boys.
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PMID:Humoral defending mechanisms in children of smoking parents. 244 22

The prevalence of respiratory diseases was followed in a group of 80 children (39 boys and 41 girls) of mean age 12.4 +/- 0.9 years during the part of school year (November - May incl.). The specimen of blood was taken from all studied children before the study started and the values of nine serum proteins were measured (IgG, IgA, IgM, IgE, alfa 1-antitrypsin = A 1-AT, transferrin = TRF, ceruloplasmin = CPL, alpha 2-macroglobulin = A 2M, lysozyme = LYS), as well as levels of two secretory proteins in saliva (sIgA and sLYS). The difference between the subgroup of boys, who fall into some respiratory illness during the observation time, and those who remain healthy, did not reach the level of significance. In contrast, the girls subgroup revealed significantly higher respiratory morbidity. With those girls, who remained healthy, the levels of serum IgE were highly increased and A 1-AT level weakly increased compared to ill girls. The level of TRF and CPL were significantly decreased with the healthy girls.
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PMID:The interrelations of some humoral factors of resistance with the prevalence of respiratory diseases in children. I. The differences among the protein levels in healthy and ill children. 617 77

All organisms are protected from harmful reactive oxygen which is produced also under physiological conditions by a complex antioxidative system. Our work was aimed at the ascertainment of the level of reduced and oxidated glutathione in erythrocytes of healthy people, the concentrations of ceruloplasmin (GSH) and transferrin (GSSG) in the serum, as well as the investigation of the relationship to antioxidative enzymes ---Cu, Zn-superoxide dismutase (SOD), catalase (CAT) and Se-glutathione-peroxidase (GPx) in erythrocytes. We discovered a mutual direct linear correlation between the levels of GSH, GSSG, CPL and TRF, indirect linear relation between the concentrations of TRF, GSH, GSSG and activities of SOD and GPx, between the concentrations of CPL and GPx activities, and a direct linear relation between concentrations of GSH and TRF with CAT activity. The results indicate to a mutual dependence of investigated nonenzymatic antioxidative factors and antioxidative enzymes. (Tab2, Fig. 4, Ref.13.).
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PMID:[Levels of erythrocyte glutathione and ceruloplasmin and transferrin in the serum and their role in antioxidant protection]. 868 24