Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.16.3.1 (ceruloplasmin)
 5,074 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twenty male alcoholics aged 29 to 69 years (mean 45.80 + SD 10.97) were compared with controls for serum zinc, copper, and ceruloplasmin levels. The serum zinc level of the alcoholic patients was significantly lower than that of the control group (t = 3.3005, p less than 0.005). The serum copper and ceruloplasmin levels of the alcoholics tended to be higher than those of the controls, but the difference was not statistically significant. A significantly positive correlation between serum zinc and albumin levels (r = 5.41, p less than 0.01) was also found. The nutritional state of the alcoholics may not be an adequate explanation for their low serum zinc level. It is suggested that further research on alcohol as a toxic agent might focus on trace element-containing enzymatic defects in brain peptides and hormones to promote fuller understanding of the psychopathology associated with alcohol abuse.
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PMID:Serum zinc, copper, and ceruloplasmin levels in male alcoholics. 649 54

A 55-year-old African Canadian man with insulin-dependent diabetes mellitus and alcohol abuse presented with diabetic ketoacidosis. Progressive cognitive decline over the previous 5 years resulted in long-term care placement. Aside from pigmentary retinopathy, general examination was unremarkable. MRI demonstrated iron accumulation in the brain (figure 1) and liver (figure 2A). Ceruloplasmin, a ferroxidase enzyme important in iron homeostasis, was undetectable and associated with low serum iron, low serum copper, and 10-fold increase in serum ferritin. Liver biopsy confirmed increased hepatocyte iron storage (figure 2B). Aceruloplasminemia was diagnosed.(1,2) Iron chelation was not administered given advanced dementia at presentation.
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PMID:Teaching NeuroImages: neurodegeneration with brain iron accumulation in aceruloplasminemia. 2421 22

Copper deficiency is a disease that causes cytopaenia and neuropathy and can be treated by copper supplementation. Long-term tube feeding, long-term total parenteral nutrition, intestinal resection and ingestion of zinc are known copper deficiency risk factors; however, alcohol abuse is not. In this case, a 71-year-old man had difficulty waking. He had a history of drinking more than five glasses of spirits daily. He was well until 3 months ago. A month before his visit to our hospital, he could not eat meals but continued drinking. He had macrocytic anaemia on admission. Copper and ceruloplasmin levels were markedly low, and we diagnosed copper deficiency. There were no other known risk factors for copper deficiency. After he began drinking cocoa as a copper supplement, the anaemia ameliorated and he was able to walk. This is the first report showing alcohol abuse as a risk factor for copper deficiency.
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PMID:Copper deficiency caused by excessive alcohol consumption. 2895 28