Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:1.16.3.1 (ceruloplasmin)
 5,074 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Inoculation to embryonate hen eggs and mice of AoPR8 influenza virus pre-incubated with ceruloplasmin (10(-7)-10(-6) M) results in a statistically significant decrease in the hemagglutinating titer of the virus, without changes in infectivity. This effect is ascribed to formation of a virus-ceruloplasmin complex, which probably interferes with both virus penetration and release of newly formed virus from the cell.
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PMID:Effect of ceruloplasmin on AoPR8 influenza virus infection in embryonate eggs and mice. 121 90

The paper presents an experimental model of toxic influenza infection. The toxic form of influenza was shown to result in the activation of free radical processes accompanied by the accumulation of both lipid peroxidation products and methemoglobin and the decrease of alpha-tocopherol in erythrocytes, by the accumulation of NO. and nitrizyl complexes of heme iron in the blood. The activation of free radical processes was followed by the stimulation of antioxidant system in the blood. Thus, there was an increase of both superoxide dismutase activity in erythrocytes and ceruloplasmin content in the blood. The data obtained support the important role of the active products of free radical processes in the development of toxicosis under acute virus infections.
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PMID:[Activation of free radicals reaction and changes in the state of antioxidant protection in blood in toxic experimental influenza infection]. 142 5

The inducer of the acute-phase response in "flu-like" viral infections is not defined. The hypothesis that virus-associated double-stranded (ds) RNA serves this function was investigated by comparison of several acute-phase responses (fever and sleep patterns, white and nucleated red blood cell levels, serum antiviral activity and ceruloplasmin) induced by the synthetic dsRNA polyriboinosinic:polyribocytidylic acid (poly[rI:rC]) with those induced by influenza virus in rabbits. The capacity of either dsRNA or influenza virus to induce hyporesponsiveness with respect to these acute-phase parameters upon rechallenge with the same agent or cross-challenge 24 h later was also examined. Poly(rI:rC) induced only minimal hyporesponsiveness to itself but was a potent inducer of hyporesponsiveness to virus with respect to fever, sleep, leukograms, and antiviral activity. Therefore, poly(rI:rC) can substitute for virus in terms of induction of acute-phase hyporesponsiveness, suggesting that dsRNA of viral origin triggers the acute-phase response in this model of influenza.
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PMID:The role of double-stranded RNA in induction of the acute-phase response in an abortive influenza virus infection model. 143 Dec 45

Systematic investigations of sleep after viral inoculation have not previously been described. In the present study, rabbits were inoculated intravenously (iv) with control allantoic fluid followed by two sequential inoculations of influenza virus at intervals of 24 h. After each i.v. inoculation, sleep and brain temperature (Tbr), as well as leukocyte distributions and serum levels of antiviral activity and ceruloplasmin, were monitored. The first viral inoculation elicited several acute phase responses, including increased non-rapid-eye-movement sleep (NREMS), Tbr, serum antiviral activity, and serum ceruloplasmin levels, as well as neutrophilia and lymphopenia. In contrast to the effects of the first inoculation, after the second inoculation of virus, all these acute phase parameters were diminished or absent (the hyporesponsive state). Inoculation of naive rabbits with heat-inactivated virus was similarly ineffective; however, inoculation of this group of rabbits with viable virus 24 h later did induce full-scale acute phase responses. The possible role of cytokines in mediating the acute phase response after influenza viral challenge is discussed. Results support the hypothesis that sleep is a facet of the acute phase response involved in host defense mechanisms.
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PMID:Influenza virus-induced changes in rabbit sleep and acute phase responses. 144 30

Multiplication of influenza virus A/PR8/34 (H1N1) in the presence of either ceruloplasmin or parainfluenza type I (Sendai) virus results in the appearance of progens different from the parental virus as regards some of their biological properties. The role of viral envelope changes in acquiring new characteristics is discussed.
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PMID:Comparative study of some characteristics of influenza virus A/PR8/34 (H1N1) cultivated on chorioallantoic membrane fragments in the presence of ceruloplasmin or of parainfluenza type I (Sendai) virus. 631 28

The results obtained at the first passage of ceruloplasmin-incubated influenza virus A/PR8/34 (H0N1) in chorioallantoic membrane fragments demonstrate the "trap effect" of ceruloplasmin and are characterized by the low values of the ratios between the hemagglutinating and neuraminidase activities and the infectivity of the resulted progens. At the 2nd passage, both in the absence and in the presence of ceruloplasmin the previously observed changes are accompanied by severe modifications in the antigenicity of the progens, as shown by the HAI titres obtained against a rabbit antiserum to influenza virus A/PR8/34 (H0N1).
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PMID:The effect of ceruloplasmin on the multiplication and on some biological and physico-chemical characteristics of influenza virus A/PR8/34 (H0N1) cultivated in chorioallantoic membrane fragments. Note 2. Modifications occurring in the course of serial passages. 714 3

The presence of ceruloplasmin in the inoculum inhibits the multiplication of influenza virus A/PR8/34 (H0N1) in chorioallantoic membrane fragments. Virus corpuscles that remain uncoupled to ceruloplasmin infect the host cells and their replication results in progens whose properties differ from those of controls inoculated in the absence of ceruloplasmin. The variation in time of the characteristics of the respective virus progens is discussed.
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PMID:The effect of ceruloplasmin on the multiplication and on some biological and physico-chemical characteristics of influenza virus A/PR8/34 (H0N1) cultivated on chorioallantoic membrane fragments. Note 1. Kinetics of virus multiplication and of some biological characteristics in the presence and absence of ceruloplasmin. 714 2

A model of the interaction between virus glycoprotein and the glycoprotein moeity of ceruloplasmia was developed on the ground of previous experimental data referring to the inhibitory action of this enzyme on the multiplication of some influenza and parainfluenza viruses and on their hemagglutinin and neuraminidase activities. The model makes evident the "trap" action exerted by ceruloplasmin on virus particles, both in the early and in the later phases of virus multiplication.
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PMID:A probable model of the inhibitory action of ceruloplasmin on the multiplication of some myxo- and paramyxoviruses. 740 12

Ceruloplasmin administered in different variants confers on mice protection against experimental infection with influenza virus APR 8/34 (H0N1). The optimal variants are: inoculation of an extemporaneous virus-ceruloplasmin mixture, followed by two additional ceruloplasmin applications (which confers maximum protection against initial infection) and the administration of ceruloplasmin prior to virus inoculation (which assures the highest resistance to challenge infection).
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PMID:The effect of ceruloplasmin on experimental infection with influenza virus APR 8/34 (H0N1) in the mouse. 743 66

The heavy chain of murine ferritin, an iron storage molecule with ferroxidase activity, was developed as a novel endogenous reporter for the detection of gene expression by magnetic resonance imaging (MRI). Expression of both enhanced green fluorescent protein (EGFP) and influenza hemagglutinin (HA)-tagged ferritin were tightly coregulated by tetracycline (TET), using a bidirectional expression vector. C6 cells stably expressing a TET-EGFP-HA-ferritin construct enabled the dynamic detection of TET-regulated gene expression by MRI, followed by independent validation using fluorescence microscopy and histology. MR relaxation rates were significantly elevated both in vitro and in vivo on TET withdrawal, and were consistent with induced expression of ferritin and increase in intracellular iron content. Hence, overexpression of ferritin was sufficient to trigger cellular response, augmenting iron uptake to a degree detectable by MRI. Application of this novel MR reporter gene that generates significant contrast in the absence of exogenously administered substrates opens new possibilities for noninvasive molecular imaging of gene expression by MRI.
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PMID:Ferritin as an endogenous MRI reporter for noninvasive imaging of gene expression in C6 glioma tumors. 1580 16


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