Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:1.16.3.1 (ceruloplasmin)
 5,074 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Changes in serum protein levels are produced by oral contraceptives. They reflect hepatic synthesis of proteins. Changes range from a 40% decrease in orosomucoid to an 180% increase in ceruloplasmin. Alterations in the concentration of some globulin proteins lead to altered serum levels of some hormones and trace metals. Plasma levels of cortisol and thyroxine are most affected. An estrogen-induced increase in thyroxine-binding globulin causes a transient reduction in free thyroxine (T4). This results in a compensatory increase in thyroid-stimulating hormone. The net effect is an unchanged concentration of T4 and the patient may be reported as euthyr id. Increases in renin substrate with rise in renin activity, angiotensin 2, and aldosterone, may be related to the development of hypertension in some women. Oral contraceptives may cause significant increases in some lipids. Elevations in cholesterol and nonesterified fatty acids are less changed. The drug-induced changes can complicate a definite diagnosis of hyperlipidemia. The glucose tolerance curve in users of oral contraceptives may simulate the diabetic type. Hepatic function tests may suggest hepatic damage. There is a higher incidence of cholecystitis and gallstones in women using oral contraceptives. Blood coagulation tests may be modified. Drug interference from oral contraceptive use must be considered in interpreting laboratory reports.
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PMID:Drug interference with laboratory tests: oral contraceptives. 1226 Jan 55

A hundred and fifty-two patients cholelithiasis were examined. Among them, 69 and 83 patients were operated on for acute destructive and chronic cholecystitis, respectively. In destructive cholecystitis, there is a high lipid oxidation rate accompanied by the elevated levels of nonenzymatic antioxidant ceruloplasmin. The low activity of catalase and ceruloplasmin and the decreased content of ascorbic acid suggest the depletion of antioxidative defense in patients with cholelithiasis with significant liver disease. The magnitude of changes in the activity of antioxidative enzymes and the level of the nonenzymatic antioxidant ascorbic acid depend on the state of the liver.
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PMID:[Antioxidative defense parameters in acute and chronic cholecystitis]. 1862 32