Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.16.3.1 (
ceruloplasmin
)
5,074
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Transcription factor networks shape the gene expression programs responsible for normal cell identity and pathogenic state. Using Core Regulatory Circuitry analysis (CRC), we identify
PAX8
as a candidate oncogene in Renal Cell Carcinoma (RCC) cells. Validation of large-scale functional genomic screens confirms that
PAX8
silencing leads to decreased proliferation of RCC cell lines. Epigenomic analyses of
PAX8
-dependent cistrome demonstrate that
PAX8
largely occupies active enhancer elements controlling genes involved in various metabolic pathways. We selected the
ferroxidase
Ceruloplasmin (CP) as an exemplary gene to dissect
PAX8
molecular functions.
PAX8
recruits histone acetylation activity at bound enhancers looping onto the CP promoter. Importantly, CP expression correlates with sensitivity to
PAX8
silencing and identifies a subset of RCC cases with poor survival. Our data identifies
PAX8
as a candidate oncogene in RCC and provides a potential biomarker to monitor its activity.
...
PMID:PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma. 3148 15
